“…In the last decade, there are barely clinical studies published analyzing the clinical evolution and the inflammatory mediator levels in the gingival crevicular fluid (GCF) after irradiation with Nd:YAG laser in the affected sites in patients with chronic periodontitis. The results obtained in four clinical studies, performed by three different research groups, should be emphasized (Gómez et al, 2011;Miyazaki et al, 2003;Qadri et al, 2010Qadri et al, , 2011. The overheating of the irradiated tissues and the consequent damage of the oral hard and soft tissues, could explain the limited support to this kind of laser radiation from the scientific community (Miserendino et al, 1994).…”