Effects of Nd:YAG laser irradiation on morphometry and lung function in elastase-induced emphysema in rats

Myosin heavy chain and physiological adaptation of the rat diaphragm in elastase-induced emphysema

“…Changes in lung volumes and compliance in the rat are more similar to those seen in humans [14-18]. An electron microscopic comparison of human emphysema with elastase-induced emphysema in rats revealed remarkably similar pictures of elastin disintegration accompanied by increased collagen deposition and reorganization [26].…”

“…Although most of the experimental work on adaptation of the diaphragm to emphysema has been performed in hamsters, rats also develop significant and often marked increases in lung volumes and compliance, and reductions in expiratory flows, after intratracheal administration of elastase [14-18]. MHC adaptation in emphysematous rat diaphragm has not been studied systematically.…”

Development of a canine model of pulmonary emphysema and imaging of the emphysematous lung with infrared thoracoscopy

“…Various methods of development of the pulmonary emphysema model have been reported. [6][7][8][9][10] However, we chose the method of bronchial injection of PPE 11 because it was simple and reliable. Evaluation of pulmonary emphysema was performed histopathologically, and damage to the alveolar structure was observed.…”