Effects of neural stem cells and 5-fluorocytosine in canine metastatic lung tumor

Abstract

This is the first case report to describe the tumor regressive effect of systemic human neural stem cell (NSC)/5-fluorocytosine (5-FC) therapy on canine metastatic lung tumor. The therapeutic effects appeared approximately two weeks after 5-FC administration. Thoracic radiographs revealed a reduced number of lung nodules and decreased nodule size. However, there were no significant antitumor effects on primary lesions in abdominal organs. In conclusion, human NSC/5-FC prodrug therapy can secure patient quality of life with the same or more therapeutic effects and fewer side effects than other recommended chemotherapies.

Therapeutic potential of the cytosine deaminase::uracil phosphoribosyl transferase/5‐fluorocytosine suicide system for canine melanoma

“…Up to date, very few data were published about the use of the CD /5‐FC system to treat spontaneous canine tumours. One of them is a clinical case report about a xenogeneic approach with genetically engineered human neural stem cells for a metastatic lung tumour with hemangiosarcoma 21 . Other‐one involves significant pre‐clinical data about the use a chimeric oncolytic vaccinia virus carrying the yeast CD::UPRT /5‐FC system for canine breast cancer 22 .…”

“…One of them is a clinical case report about a xenogeneic approach with genetically engineered human neural stem cells for a metastatic lung tumour with hemangiosarcoma. 21 Other-one involves significant pre-clinical data about the use a chimeric oncolytic vaccinia virus carrying the yeast CD::UPRT/5-FC system for canine breast cancer. 22 In previous reports 3,4 the TK/GCV suicide gene system was intra-and/or peritumourally added to achieve local control of canine melanoma after tumour surgery.…”