Effects of nicotine on weight change and food consumption in rats

McNair, Eileen; Bryson, Rebecca

doi:10.1016/0091-3057(83)90451-3

Cited by 49 publications

(31 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Even if obtained on water-deprived subjects, this finding seems in contrast with the bulk of the literature on adult subjects, nicotine administration being generally associated with a loss of body weight (see e.g. McNair and Bryson 1983;Grunberg et al 1987). Consistently, a similar result has been recently reported in adolescent female rats (Faraday et al 2001).…”

Section: Fluid Intake and Body Growth Ratesupporting

confidence: 47%

Peculiar Vulnerability to Nicotine Oral Self-administration in Mice during Early Adolescence

Adriani

Macrı̀

Pacifici

et al. 2002

Neuropsychopharmacology

196

142

View full text Add to dashboard Cite

(10 mg/l). After a 6-day period, a fading study was carried out, in which nicotine concentration was reduced to 7 mg/l (days 7-9) and 5 mg/l (days 10-12), to assess whether animals would compensate by increasing their intake from the nicotine solution. In Experiment 2, psychopharmacological effects on locomotion induced by the nicotine solution (0, 10, 30 mg/l) Recent research has emphasized that adolescence is associated with patterns of temporary deviance (Arnett 1992) and the use of various kinds of psychoactive agents (Mathias 1996). Drug abuse in adolescents ranging from 11-12 to 17-18 years of age is likely to start with tobacco smoking, which can be followed by marijuana and/or 1991;Breslau et al. 1993;Nides et al. 1995;Kandel and Chen 2000). Despite the social and scientific importance of deepening our knowledge of this issue (see e.g. Colby et al. 2000), there have been very few investigations on the psychobiological factors contributing to the specific adolescence-related willingness to experience various psychoactive drugs (for a review, see Laviola et al. 1999;Spear 2000). For the purpose of laboratory studies, a suitable animal model of human adolescence is available in rodents. Namely, periadolescence is classically defined as the ontogenetic period that encompasses the week preceding the onset of puberty and the first few days thereafter (Spear and Brake 1983). Periadolescent rodents differ markedly from adults in their spontaneous behavioral repertoire (Cirulli et al. 1996;Terranova et al. 1993;Meaney and Stewart 1981;Panksepp 1981). In fact, elevated levels of novelty seeking and a reduced behavioral and hormonal response to stress (Adriani et al. 1998;Adriani and Laviola 2000) are exhibited by animals around this age. A characteristic hyporesponsivity to the effects of an acute administration of psychostimulants (Spear and Brake 1983;Laviola et al. 1995;Bolanos et al. 1998;Adriani and Laviola 2000), a peculiar pattern of behavioral sensitization following repeated drug exposure (Laviola et al. 1995(Laviola et al. , 2001Adriani et al. 1998), as well as a weak drug-induced place conditioning profile (Adriani et al. 1998;Bolanos et al. 1996Bolanos et al. , 1998 but see Campbell and Spear 2000), are also reported. Based on these findings, an increased vulnerability to the addictive properties of abused drugs has been suggested to be typical of adolescence in both humans and animals models (see Laviola et al. 1999).In the present study, we were interested in nicotine, which beside being the main psychoactive compound implied in tobacco smoking, also shares most of the characteristics of other addictive drugs (Corrigall et al. 1992(Corrigall et al. ,1994Pontieri et al. 1996;Merlo-Pich et al. 1997;Stolerman 1999). Nicotine's effects in mice have been shown to be highly dependent on the genetic background (see Marks et al. 1989;Robinson et al. 1996). However, the interaction between the pharmacological effects and the incentive properties of nicotine during the adolescent period has been largel...

show abstract

Section: Fluid Intake and Body Growth Ratesupporting

confidence: 47%

Peculiar Vulnerability to Nicotine Oral Self-administration in Mice during Early Adolescence

Adriani

Macrı̀

Pacifici

et al. 2002

Neuropsychopharmacology

196

142

View full text Add to dashboard Cite

show abstract

“…Confounding factors contributing to PVN gene expression changes are nicotine-induced reduction in food intake and weight gain (McNair and Bryson, 1983). However, a previous study reported that expression of CRF and AVP mRNA was unaffected by restricting feeding to 2 h/d (Johnstone et al, 2005).…”

Section: Discussionmentioning

confidence: 93%

Nicotine Self-Administration Differentially Regulates Hypothalamic Corticotropin-Releasing Factor and Arginine Vasopressin mRNAs and Facilitates Stress-Induced Neuronal Activation

Yu¹,

Chen²,

Zhao³

et al. 2008

J. Neurosci.

View full text Add to dashboard Cite

Acute nicotine is a potent stimulus for activation of the stress-responsive hypothalamic-pituitary-adrenal (HPA) axis, while chronic nicotine self-administration (SA) desensitizes the ACTH response to self-administered nicotine but cross-sensitizes to mild footshock stress (mFSS). To identify underlying mechanisms, we investigated (1) the effects of chronic nicotine SA on the coexpression of corticotropin-releasing factor (CRF) and arginine vasopressin (AVP) mRNAs, the primary hypothalamic neuropeptides regulating ACTH release, in the parvocellular division of paraventricular nucleus (pcPVN), and (2) /AVP ϩ population was activated by this heterotypic stressor. These phenotypic neuronal alterations may provide the pivotal mechanism underlying the capacity of chronically selfadministered nicotine to cross-sensitize the HPA response to specific stressors, suggesting that nicotine may augment HPA responsiveness to specific stressors in human smokers.

show abstract

“…Drug dependence is known to involve appetitive mechanisms, and the effects of nicotine on body weight, eating, and obesity are therefore likely to contribute to nicotine addiction. Starting from pioneering studies in the 1970s and early 1980s (Falkeborn, Larsson, & Nordberg, 1981;Grunberg, 1982;Grunberg, Bowen, Maycock, & Nespor, 1985;McNair & Bryson, 1983;Schechter & Cook, 1976;Wack & Rodin, 1982), multiple effects of nicotine and smoking on food consumption, energy expenditure, as well as food hedonics have been identified. In this review, we will outline the cellular and molecular mechanisms that may underlie the effects of nicotine on energy intake, expenditure, and hedonics of food consumption.…”

Section: Introductionmentioning

confidence: 99%

Nicotinic Regulation of Energy Homeostasis

Zoli

Picciotto

2012

Nicotine & Tobacco Research

View full text Add to dashboard Cite

Introduction: The ability of nicotine, the primary psychoactive substance in tobacco smoke, to regulate appetite and body weight is one of the factors cited by smokers that prevents them from quitting and is the primary reason for smoking initiation in teenage girls. The regulation of feeding and metabolism by nicotine is complex, and recent studies have begun to identify nicotinic acetylcholine receptor (nAChR) subtypes and circuits or cell types involved in this regulation.

show abstract

Effects of nicotine on weight change and food consumption in rats

Cited by 49 publications

References 8 publications

Peculiar Vulnerability to Nicotine Oral Self-administration in Mice during Early Adolescence

Peculiar Vulnerability to Nicotine Oral Self-administration in Mice during Early Adolescence

Nicotine Self-Administration Differentially Regulates Hypothalamic Corticotropin-Releasing Factor and Arginine Vasopressin mRNAs and Facilitates Stress-Induced Neuronal Activation

Nicotinic Regulation of Energy Homeostasis

Contact Info

Product

Resources

About