Effects of nigella sativa and nimodipine on oxidative stress and apoptosis in serum and brain tissue in rats with experimental head trauma.

Kamaşak, Kağan; Basarslan, Kagan; Dagli, Ahmet Turan; Öğden, Mustafa; Alabalık, Ulaş; Ekinci, Adnan; Ceviz, Adnan

doi:10.5137/1019-5149.jtn.25523-19.3

Cited by 6 publications

(4 citation statements)

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“…There are multiple antioxidant has shown neuroprotective effects in Pre-VPA exposed animals In present study, Nimodipine was found to reduce the TBAR levels followed by increase in GSH in Pre-VPA exposed rats. Several previous finding also suggest for antioxidant activity of nimodipine by working on antioxidant and related pathways such as activation of CREB and AKT signaling pathways [ 62 , 63 ]. The above line of discussion that may conclude, nimodipine possibly modulates the endogenous antioxidant pathways and results in decrease oxidative stress in Pre-VPA exposed rats.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Nimodipine Against Valproic-acid Induced Biochemical and Behavioral Phenotypes of Autism

Kumar

Diwan

Sharma

2022

Clin Psychopharmacol Neurosci

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Objective: Present study was designed to investigate behavioral and biochemical role of nimodipine in prenatal valproic acid (Pre-VPA) induced autism in rats. Methods: Valproic acid was utilized to induce autistic phenotypes in Wistar rats. The rats were assessed for social behavior. Hippocampus and prefrontal cortex (PFC) were utilized for various biochemical assessments, whereas cerebellum was used to assess blood brain barrier (BBB) permeability. Results: Pre-VPA rats showed reduction social interaction. Pre-VPA administration were decreased PFC levels of interleukin-10 (IL-10), and glutathione along with hippocampus cAMP response element-binding protein (CREB) and brain-derived neurotrophic factor (BDNF). Also, the animals have shown increase in PFC levels of IL-6, tumor necrosis factor-α, thiobarbituric acid reactive substance, Evans blue leakage and water content. Nimodipine countered Pre-VPA administered reduction in social interaction, CREB, BDNF, inflammation, oxidative stress, BBB permeability. Conclusion: Pre-VPA has induced autistic phenotype, which were attenuated by nimodipine in rats. Nimodipine and other calcium channel blockers should further investigate to check the management of autism.

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Section: Discussionmentioning

confidence: 99%

Protective Effect of Nimodipine Against Valproic-acid Induced Biochemical and Behavioral Phenotypes of Autism

Kumar

Diwan

Sharma

2022

Clin Psychopharmacol Neurosci

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“…[19] It was shown that nimodipine inhibited endothelial cell apoptosis by reducing intracellular calcium in ux in animal models of ischemia. [20][21][22] However, the route of administration of nimodipine in these studies was not enteral (intravenous infusion) and endothelial cell death was also not shown. Herein, we studied the effect of enteral nimodipine on endothelial apoptosis in the early phase after experimental SAH using immunohistochemical staining of apoptosis-related proteins (Bcl2 [anti-apoptotic] and Bax [proapoptotic]) in large arteries and small arterioles.…”

Section: Introductionmentioning

confidence: 84%

The Impact of Enteral Nimodipine on Endothelial Cell Apoptosis in an Animal Subarachnoid Hemorrhage Model

Cho,

Byoun,

Park

et al. 2024

Neurocrit Care

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Objective: Enteral nimodipine is the most evidence-based and widely used drug for the treatment of delayed cerebral ischemia (DCI) and is known to have various neuroprotective functions. However, the neuroprotective mechanism of nimodipine still remains unclear and the effects of nimodipine remain ambiguous. Herein, we studied the effect of enteral nimodipine on endothelial apoptosis after subarachnoid hemorrhage (SAH).Method: SAH was experimentally introduced in white rabbits (n=42) that were grouped: enteral nimodipine (group N, n=14); a control that received normal saline (group S, n=13); and a control without hemorrhage (group C, n=15). On the third day after SAH induction, the brain stem, including the vertebrobasilar vascular system, was extracted. The effects of enteral nimodipine were analyzed by group using histopathologic analysis, including immunohistochemical staining of apoptosis-related proteins (Bcl2 [anti-apoptotic] and Bax [pro-apoptotic]).Result: Cytoplasmic vacuolation of smooth muscle cells was observed in groups S and N, and was more prominent in group S. Endothelial desquamation was observed only in group S. For the basilar artery, expression of Bcl2 and Bax in group N was lower than in group S, but signi cant differences were not observed (p = 0.310 and p = 0.710, respectively). In penetrated arterioles, the expression of Bax in group N was signi cantly lower than that of group S (p < 0.001). The thickness of the tunica media in the basilar artery was thinner in group N than in group S (p < 0.001). Conclusion:This study suggests that enteral nimodipine may have a neuroprotective function by inhibiting endothelial apoptosis in small arterioles and preventing smooth muscle cell proliferation in large arteries.

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“…Similarly, the probable mechanism for the action of nimodipine could also be by prevention of neuroinflammation 36 . A study by Kamasak and Adnan (2019) had revealed that nimodipine has an antioxidant property that may have contributed in reducing oxidative stress 37 .…”

Section: Discussionmentioning

confidence: 99%

Untitled

2022

IJPSR

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The present study aimed to assess the role of angiotensinconverting enzyme inhibitor (trandolapril) and calcium channel blocker (nimodipine) in anxiety, depression, and motor coordination using behavioral models in mice. This was an experimental study involving 72 swiss albino mice divided into 12 groups. Groups 1 to 4 were used to evaluate the anxiolytic effect using Y maze after 5 days of treatment. Groups 5 to 8 were used to evaluate the antidepressant effect using forced swim test on days 1, 10, 20, and 30. Groups 9 to 12 were used to evaluate the effect on motor coordination using the Rotarod apparatus at 0, 30, 60, 90, 120 min. Statistical evaluation was done by ANOVA. P < 0.05 was considered statistically significant. Fall-off time was significantly earlier in only the standard group at 30 and 60 min. The period of immobility was lower in both the test groups on day 30. The total number of visits significantly decreased in both the test groups and standard groups on day 5. The results showed the presence of antidepressant and anxiolytic effects in both the test groups without muscle relaxant property. Therefore it can be proposed that both trandolapril and nimodipine can be new possible targets for treating anxiety and depression without affecting motor coordination at presently used doses.INTRODUCTION: Chronic non-communicable diseases are a major concern worldwide as it carries a significant load of morbidity and mortality.

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Effects of nigella sativa and nimodipine on oxidative stress and apoptosis in serum and brain tissue in rats with experimental head trauma.

Cited by 6 publications

References 0 publications

Protective Effect of Nimodipine Against Valproic-acid Induced Biochemical and Behavioral Phenotypes of Autism

Protective Effect of Nimodipine Against Valproic-acid Induced Biochemical and Behavioral Phenotypes of Autism

The Impact of Enteral Nimodipine on Endothelial Cell Apoptosis in an Animal Subarachnoid Hemorrhage Model

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