Effects of Nigella sativa, Camellia sinensis, and Allium sativum as Food Additives on Metabolic Disorders, a Literature Review

Abstract

Objective: Metabolic disorders (MD) can disturb intracellular metabolic processes. A metabolic disorder can be resulted from enzyme deficits or disturbances in function of various organs including the liver, kidneys, pancreas, cardiovascular system, and endocrine system. Some herbs were used traditionally for spices, food additives, dietary, and medicinal purposes. Medicinal plants possess biological active compounds that enhance human health. We aimed to provide evidence about therapeutic effects of some medicinal herbs on MD.Data Sources: PubMed, Scopus, and Google Scholar were explored for publications linked to MD until February 2021. The most literature reports that were published in the last 10 years were used. All types of studies such as animal studies, clinical trials, and in vitro studies were included. The keywords included “Metabolic disorders,” “Nigella sativa L.,” “Thymoquinone,” “White tea”OR “Camellia sinensis L.” “catechin,” and “Allium sativum L.” OR “garlic” were searched.Results: Based on the results of scientific studies, the considered medicinal plants and their active components in this review have been able to exert the beneficial therapeutic effects on obesity, diabetes mellitus and non-alcoholic fatty liver disease.Conclusions: These effects are obvious by inhibition of lipid peroxidation, suppression of inflammatory reactions, adjustment of lipid profile, reduction of adipogenesis and regulation of blood glucose level.

Lipid-Lowering Efficacy of the Capsaicin in Patients With Metabolic Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

“…For example, studies have shown that daily intake of red yeast rice can reduce LDL-C levels from 15% to 25% ( 13 ). In addition, glucomannan ( 14 , 15 ), probiotics ( 14 , 16 ), garlic ( 17 ), berberine ( 18 ), omega-3 (ω′-3) and fatty acids ( 19 ), also have a positive effect on improving MetS.…”

Catechic Tannin Content of Different Tea Samples

“…Based on the literature, when the catechin and epigallocatechin gallate contents of white and green tea were compared, it was higher in green tea (12,(24)(25)(26). Furthermore, these results that showed higher catechin proportions found in white tea could explain its high biological activities (anti-oxidant, anti-inflammatory, anti-cancer, anti-diabetic, anti-microbial, and reduced cardiovascular diseases) in comparison to green and black teas (11,(27)(28). In conclusion, the literature reviews have shown that there are no detailed scientific studies on white, green, and black tea grown in Turkey and white tea has been considered as requiring clinical trials.…”

Nigella sativa and health outcomes: An overview of systematic reviews and meta-analyses

“…Many scientific studies have demonstrated that N. sativa has a broad spectrum of positive pharmacological effects, including antiviral ( 10 ), anti-inflammatory ( 11 ), hypotensive ( 12 ), hypoglycemic ( 13 ) and antitumor ( 14 ) effects. These biological properties are related to the abundance of several phytochemicals, including thymoquinone, terpenes, saponins, flavonoids, and essential oils ( 8 , 15 ). These promising active ingredients and their biological properties make N. sativa a powerful natural candidate for the prevention and control of diseases.…”