Effects of Nigella sativa Extracts on the Lipid Profile and Uncoupling Protein-1 Gene Expression in Brown Adipose Tissue of Mice

Mahmoudi, Amin; Samani, Keihan Ghatreh; Farrokhi, Effat; Heidarian, Esfandiar

doi:10.4103/abr.abr_91_18

Cited by 12 publications

(8 citation statements)

References 23 publications

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“…In this regard, the results of a study showed that the use of Nigella sativa significantly reduced levels of total cholesterol, LDL, and triglyceride (23). It has also been reported that the use of Nigella sativa reduces levels of cholesterol and triglyceride (24). In traditional books, Nigella sativa used to treat hyperlipidaemia, which is consistent with the findings of the present study (25).…”

Section: Discussionsupporting

confidence: 93%

Lipid Lowering Effects of Nigella sativa and Swimming Training in Streptozotocin Induced Diabetic Rats

Hoseini¹,

Zar²,

Dehghani³

2018

Ann Mil Health Sci Res

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Background: Diabetes is a chronic disease that causes disorders in blood lipids. Objectives: The purpose of this study was to investigate the lipid lowering effects of hydroalcoholic extract of Nigella sativa and swim training in streptozotocin-induced diabetic rats. Methods: A total of 32 diabetic rats were selected and randomly divided into four equal-size groups: (1) Swim training, (2) Nigella sativa, (3) swim training with Nigella sativa, and (4) control. Groups 2 and 3 received 100 mg/kg/day of Nigella sativa extract in the peritoneum. Groups 1 and 3 also swam in a swimming tank (five days per week for four weeks). After this period, blood samples were taken. For analysis of the findings, Paired Sample t-test and two-way ANOVA were used (P ≤ 0.05). Results:Swim training and Nigella sativa consumption had a significant effect in reducing cholesterol (Cho), triglycerides (TG), very low-density lipoprotein (VLDL), and low-density lipoprotein (LDL) (P ≤ 0.05); high-density lipoprotein (HDL) increased significantly following swim training (P ≤ 0.05); Nigella sativa and swim training had significant interactive effects in reducing Cho, TG, VLDL, and LDL, and in increasing HDL (P ≤ 0.05). Conclusions:It seems that four weeks of Nigella sativa consumption combined with swimming training has a more favourable fat-reducing effect than Nigella sativa consumption or swim training alone.

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Section: Discussionsupporting

confidence: 93%

Lipid Lowering Effects of Nigella sativa and Swimming Training in Streptozotocin Induced Diabetic Rats

Hoseini¹,

Zar²,

Dehghani³

2018

Ann Mil Health Sci Res

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“…Some studies suggest that N. sativa oil and extracts have antioxidant properties and can modulate oxidative stress, which could be beneficial for oxidative stress related diseases/disorders. In this sense, oils and solvent extracts from N. sativa seeds possessed antioxidant activity in vitro ( Toma et al, 2015 ; Mohammed et al, 2016 ; Abedi et al, 2017 ; Singhal et al, 2017 ), ex vivo ( Ghoreyshi et al, 2020 ), in vivo ( Mahmoudi et al, 2018 ; Rasoli et al, 2018 ) and in humans ( Nikkhah-Bodaghi et al, 2019 ). Moreover, in vivo regular intake of ethanolic extract of N. sativa seed (400 mg/kg) lowered the lipid peroxidation, and enhanced catalase activity in Wistar rats ( Rasoli et al, 2018 ).…”

Section: Biological Activities: Preclinical In Vitro/in Vivo Studies Of the Genus Nigella And Activmentioning

confidence: 99%

“…Another work suggested that hydroalcoholic and hexane extracts of N. sativa seed as well as thymoquinone may counteract oxidative stress caused by high-fat diets (HFDs), e.g. malondialdehyde (MDA) levels decreased, while the activity of catalase enzyme and serum total antioxidant capacity increased ( Mahmoudi et al, 2018 ). Concerning other Nigella species, N. damacena 70% ethanolic extract (seeds) has shown antioxidant properties in vitro , even higher generally than N. sativa seeds ( Toma et al, 2015 ); the former contained higher amounts of quercetin derivatives.…”

Section: Biological Activities: Preclinical In Vitro/in Vivo Studies Of the Genus Nigella And Activmentioning

confidence: 99%

“…Nigella sativa fruit and seed extracts and oil (33% thymoquinone) have shown antiobesity potential using in vitro and in vivo studies, and the mechanisms include the inhibition of pancreatic lipase and α-amylase (15–100%, depending on the extract and enzyme), proinflammatory cytokine production in pre-adipocytes (a model of low-grade inflammation in Simpson–Golabi–Behmel syndrome human) and weight loss, by positively affecting the uncoupling protein-1 (UCP-1), which the index protein of the brown adipose tissue used in the obesity studies ( Buchholz and Melzig, 2016 ; Mahmoudi et al, 2018 ; Bordoni et al, 2019 ).…”

Section: Biological Activities: Preclinical In Vitro/in Vivo Studies Of the Genus Nigella And Activmentioning

confidence: 99%

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Nigella Plants – Traditional Uses, Bioactive Phytoconstituents, Preclinical and Clinical Studies

et al. 2021

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Nigella is a small genus of the family Ranunculaceae, which includes some popular species due to their culinary and medicinal properties, especially in Eastern Europe, Middle East, Western, and Central Asia. Therefore, this review covers the traditional uses and phytochemical composition of Nigella and, in particular, Nigella sativa. The pharmacological studies reported in vitro, in vivo, and in humans have also been reviewed. One of the main strength of the use of Nigella is that the seeds are rich in the omega-6 fatty acid linoleic acid and provide an extra-source of dietary phytochemicals, including the bioactive thymoquinone, and characteristics saponins, alkaloids, and flavonoids. Among Nigella species, N. sativa L. is the most studied plant from the genus. Due to the phytochemical composition and pharmacological properties, the seed and seed oil from this plant can be considered as good candidates to formulate functional ingredients on the basis of folklore and scientific knowledge. Nonetheless, the main limations are that more studies, especially, clinical trials are required to standardize the results, e.g. to establish active molecules, dosage, chemical profile, long-term effects and impact of cooking/incorporation into foods.

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“…Previous studies have highlighted that N. sativa oil has anti-inflammatory, anti-oxidant, immunomodulatory, and anti-cancer activities [2,3]. Recently, other investigations have addressed the possibility that N. sativa oil improves glucose homeostasis and lipid profile [4,5]. Additionally, pharmacological studies have highlighted that N. sativa oil can have gastroprotective, hepatoprotective, antitussive, cardioprotective, and anti-hypertensive properties [1].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and Anti-Inflammatory Properties of Nigella sativa Oil in Human Pre-Adipocytes

et al. 2019

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The oil obtained from the seeds of Nigella sativa L. (N. sativa), also known as black cumin, is frequently used in the Mediterranean area for its anti-inflammatory, anti-oxidant, and anti-cancer activities. The aim of the present study was to evaluate the antioxidant and anti-inflammatory properties of the oil extracted from seeds of a N. sativa cultivar produced in the Marche region of Italy, and to determine if the thymoquinone content, antioxidant properties, and biological activity would decay during storage. Cytotoxicity and anti-inflammatory properties of N. sativa oil were tested in an in vitro model of low-grade inflammation in Simpson–Golabi–Behmel syndrome human pre-adipocytes. The fresh extracted oil (FEO) contained 33% more thymoquinone than stored extracted oil (SEO), demonstrating that storage affects its overall quality. In addition, the thymoquinone content in the N. sativa oil from the Marche region cultivar was higher compared with other N. sativa oils produced in the Middle East and in other Mediterranean regions. Pro-inflammatory cytokines (e.g., Interleukin (IL)-1alpha, IL-1beta, IL-6) were differently modulated by fresh and stored extracts from N. sativa oils: FEO, containing more thymoquinone reduced IL-6 levels significantly, while SEO inhibited IL-1beta and had a higher antioxidant activity. Total antioxidant activity, reported as µM of Trolox, was 11.273 ± 0.935 and 6.103 ± 0.446 for SEO and FEO (p = 1.255 × 10−7), respectively, while mean values of 9.895 ± 0.817 (SEO) and 4.727 ± 0.324 (FEO) were obtained with the 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) assay (p = 2.891 × 10−14). In conclusion, the oil capacity to counteract proinflammatory cytokine production does not strictly depend on the thymoquinone content, but also on other antioxidant components of the oil.

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Effects of Nigella sativa Extracts on the Lipid Profile and Uncoupling Protein-1 Gene Expression in Brown Adipose Tissue of Mice

Cited by 12 publications

References 23 publications

Lipid Lowering Effects of Nigella sativa and Swimming Training in Streptozotocin Induced Diabetic Rats

Lipid Lowering Effects of Nigella sativa and Swimming Training in Streptozotocin Induced Diabetic Rats

Nigella Plants – Traditional Uses, Bioactive Phytoconstituents, Preclinical and Clinical Studies

Antioxidant and Anti-Inflammatory Properties of Nigella sativa Oil in Human Pre-Adipocytes

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