Effects of Nitrogen Dioxide on Mycoplasma Pulmonis Infection and Humoral Immune Responses in Mice

Effects of <I>Mycoplasma pulmonis</I> Infection and Exposure to Nitrogen Dioxide on Activities on Natural Killer Cells and Macrophages of the Mouse

“…The ddY mouse was less susceptible to the organism. However, exposure of infected ddY moose to NO2 led to an increased rate of multiplication of Mp and formation of lung lesion [9] . Bacterial clearance showed significant changes after exposure of the mouse to NO2 [2,3].…”

“…It also appeared that the infection profile was influenced by exposing the mouse to air pollutive substance [9,12]. NK activity of the mouse exposed to N02 for 5 months was at a comparable level with that of unexposed control mouse (T. Kamiyama et al, unpublished data).…”

“…Bacterial clearance showed significant changes after exposure of the mouse to NO2 [2,3]. However, exposure of the mouse to NO2 did not affect on anti-Mp antibody production in the infected mice [9].…”

“…2 We have shown that aerosol-infection using an inhalation chamber was effective to demonstrate pathogenicity of respiratory infective agents such as Mp [8]. The mouse exposed to the aerosol produced high titer of serum antibody [9].…”