Effects of Nitroglycerin and Nitroprusside on the Uterine Vasculature of Gravid Ewes

Wheeler, Andrew A.; James, Francis M.; Meis, Paul J.; Rose, James C.; Fishburne, John I.; Dewan, David M.; Urban, R. B.; Greiss, Frank C.

doi:10.1097/00000542-198005000-00003

Cited by 51 publications

(19 citation statements)

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“…The first was vascular relaxation, as noted in the uterine artery, 13 the UA, 14,15 and vasculature in the placenta. 16 Because endothelial cells, which are major sources of NO, are known to be injured in preeclamptic women, NO donors may assume the role of the impaired NO synthesis in the vascular vessels of these patients.…”

Section: Discussionmentioning

confidence: 99%

A Long‐term Transdermal Nitric Oxide Donor Improves Uteroplacental Circulation in Women With Preeclampsia

Nakatsuka

Takata

Tada

et al. 2002

J of Ultrasound Medicine

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Objective. To determine the effects of long-term transdermal administration (range, 4-30 days; mean ± SD, 11.1 ± 7.2 days) of isosorbide dinitrate, a nitric oxide donor, in preeclamptic women. Methods. We studied uterine and fetoplacental circulation of 12 preeclamptic women with oligohydramnios and an elevated pulsatility index in the uterine arteries. Results. Transdermal isosorbide dinitrate significantly suppressed the blood pressure of patients. Pulsed Doppler ultrasonography revealed that the average pulsatility index in the uterine arteries was significantly reduced by treatment with isosorbide dinitrate (P < .003). The average pulsatility index in the umbilical artery was also significantly reduced (P < .004). Furthermore, the size of the amniotic fluid pocket increased approximately 4-fold by treatment with isosorbide dinitrate. Conclusions. Long-term transdermal administration of isosorbide dinitrate improves fetoplacental circulation and may be effective therapy for avoiding maternal hypertension and oligohydramnios in some preeclamptic women.

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Section: Discussionmentioning

confidence: 99%

A Long‐term Transdermal Nitric Oxide Donor Improves Uteroplacental Circulation in Women With Preeclampsia

Nakatsuka

Takata

Tada

et al. 2002

J of Ultrasound Medicine

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“…The first is vascular relaxation as noted in uterine arteries [9], umbilical artery [10,11], and/or vasculature in the placenta [12]. It had been reported as early as 1980 that nitroglycerin and sodium nitroprusside, both NO donors, antagonize norepinephrine-induced vasoconstriction in the uterus of pregnant ewes [9]. Because endothelial cells which are major sources of NO are known to be injured in preeclamptic women, NO donors may replace the impaired NO synthesis in vascular vessels of these patients.…”

Section: Discussionmentioning

confidence: 99%

Clinical Experience of Long-Term Transdermal Treatment with Nitric Oxide Donor for Women with Preeclampsia

Nakatsuka

Tada

Kimura

et al. 1999

Gynecol Obstet Invest

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Isosorbide dinitrate (ISDN), a nitric oxide donor, was applied transdermally for 4–16 days to 4 preeclamptic women with oligohydramnios, intrauterine fetal growth retardation (IUGR), and elevated resistance of blood flow in the uterine arteries. Pulsed Doppler ultrasonography revealed immediate and drastic improvement of pulsatility index (PI) of uterine arteries following treatment with ISDN. The average PI in uterine arteries of the 4 patients was reduced to approximately 67% of that of the untreated state. In 2 patients the amniotic fluid gradually increased over a few days which suggested improvement of fetoplacental circulation during administration of ISDN. This study suggests that long-term transdermal ISDN is an effective therapy, at least in a portion of preeclamptic women, to avoid maternal hypertension, fetal distress, oligohydramnios, and IUGR, and consequentially to prolong the gestational period.

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“…21,22 If the infusion is stopped, the blood pressure returns to the pretreatment levels within one to ten minutes. Sodium nitroprusside is more potent than hydralazine for reducing blood pressure 23 and, because of the decrease in systemic pressure, it signifi cantly reduces blood fl ow to the kidneys, uterus and placenta. 24,25 In pregnant and non-pregnant women, SNP also produces more intense uterine artery dilatation than does hydralazine.…”

Section: Discussionmentioning

confidence: 99%

Does sodium nitroprusside kill babies? A systematic review

et al. 2007

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Effects of Nitroglycerin and Nitroprusside on the Uterine Vasculature of Gravid Ewes

Cited by 51 publications

References 0 publications

A Long‐term Transdermal Nitric Oxide Donor Improves Uteroplacental Circulation in Women With Preeclampsia

A Long‐term Transdermal Nitric Oxide Donor Improves Uteroplacental Circulation in Women With Preeclampsia

Clinical Experience of Long-Term Transdermal Treatment with Nitric Oxide Donor for Women with Preeclampsia

Does sodium nitroprusside kill babies? A systematic review

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