Effects of nonylphenol on juveniles and adults in the grey mullet, Liza aurata

Regulation of reproduction- and biomarker-related gene expression by sex steroids in the livers and ovaries of adult female western mosquitofish (Gambusia affinis)

“…Although data concerning the responses of CYP1A to P and T in fish are unavailable from previous studies, some studies about the effects of E2 or xenoestrogen on CYP1A mRNA expression are in agreement with our results. For example, E2 and xenoestrogen (nonylphenol, NP) could inhibited the expression levels of CYP1A mRNA in juvenile and adult gray mullet (Cionna et al, 2006). Kim et al (2008) also found CYP1A expression tended to decrease in the liver of male medaka after exposure to E2.…”

“…For example, equilenin (an estrogen) was able to dose-dependently increase both ethoxyresorufin O-deethylase activity (EROD) in mice, and it also induced CYP1A mRNA in treated HepG2 cell lines (Jinno et al, 2006). However, on the contrary, some previous studies showed that E2 could inhibit CYP1A mRNA expression in fish (Navas and Segner, 2001;Cionna et al, 2006;Kim et al, 2008). Thus, it is interesting to study CYP1A mRNA expression in fish in response to steroid hormones.…”

Effects of nonylphenol and 3,3′,4,4′,5-pentachlorobiphenyl on in vitro oocyte steroidogenesis in redlip mullet,Chelon haematocheilus

“…However, an opposite effect was found in a study using Atlantic salmon in which exposure to NP caused a 24Á43% decrease in plasma E 2 levels (Arukwe et al 1997). Using grey mullet (Liza aurata), Cionna et al (2006) reported that the estrogenic effect of NP was elicited only by the highest dose (250 mg/kg body weight); a lower dose of NP (0.25 mg/kg body weight) did not induce vitellogenesis or increase plasma vitellogenin levels. In the present study, we found that NP inhibited endogenous E 2 production by vitellogenic oocytes (0.65Á0.75-mm diameter) at lower concentrations (0.01 and 0.1 ng/ml).…”

“…An opposite effect was found in a study using Atlantic salmon (Salmo salar), in which exposure to NP caused a 24Á43% decrease in plasma E 2 levels (Arukwe et al 1997). Recently, Cionna et al (2006) reported that in grey mullet (Liza aurata), NP exerts estrogenic effects only at the highest dose injected. However, the mechanism by which NP exerts estrogenic and other endocrine disrupting effects remains unclear.…”

“…Mullet species have been used for many years in coastal pollution monitoring programs (UNEP 1997) due to their widespread distribution where toxic compounds reach the sea and bioaccumulate in sediment (Cionna et al 2006;Hong et al 2009). …”