Effects of norgestimate in combination with ethinyl estradiol on cervical mucus

Mohsenian, Mohammad; Moghissi, Kamran S.; Borin, Katherine

doi:10.1016/0010-7824(81)90090-1

Cited by 4 publications

(6 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The in vitro sperm penetration test was maximal at midcycle in all patients and was absent after ovulation. These findings are in agreement with data reported previously by our group [3]. Figure I illustrates fluctuations in the means (+SEM) of cervical mucus scores, the in vitro sperm penetration tests, karyopyknotic indices of vaginal cytology and BBT of the control cycles in all 5 subjects.…”

Section: Control Cyclesupporting

confidence: 94%

“…These alterations were consistent with inhibition of ovulation. Similar changes, but to a lesser extent, were observed previously when Ng 0.125 mg combined with EE 0.035 mg was used in an identical manner [3]. It is known that the contraceptive effects of progestins are exerted at different levels, such as suppresssion of ovulation, inhibition of sperm migration through the cervix and alteration of endometrial morphology preventing implantation [5--7].…”

Section: Discussionsupporting

confidence: 81%

“…A combination of norgestimate with EE in the above dosage was found to inhibit ovulation and also exerted a direct effect on the cervical mucus [3]. In field trials, however, this combination was associated with an unacceptably high pregnancy rate.…”

Section: Introductionmentioning

confidence: 83%

See 2 more Smart Citations

Effects of norgestimate (0.250 mg) in combination with ethinyl estradiol (0.035 mg) on cervical mucus

Hull

Moghissi

1986

Adv Contracept

View full text Add to dashboard Cite

The antifertility effect of norgestimate (Ng), 0.250 mg, in combination with ethinyl estradiol (EE), 0.035 mg, on cervical mucus was investigated. The study was conducted over two consecutive cycles: a control cycle followed by a study cycle during which medication was given. Basal body temperature, cervical mucus and karyopyknotic index of vaginal cells were evaluated during both cycles. Disappearance of cyclicity of these parameters in the study cycle as well as monophasic basal body temperature were suggestive of inhibition of ovulation caused by the combination pill. Deterioration of sperm penetration may be reflective of anovulation and a direct antifertility effect of Ng on cervical mucus.

show abstract

Section: Control Cyclesupporting

confidence: 94%

Section: Discussionsupporting

confidence: 81%

See 1 more Smart Citation

Effects of norgestimate (0.250 mg) in combination with ethinyl estradiol (0.035 mg) on cervical mucus

Hull

Moghissi

1986

Adv Contracept

View full text Add to dashboard Cite

show abstract

“…The finding can be explained in terms of the physiological increase in volume of the cervi cal mucus, and also the change of its hydrogel structure. The pH of the cervical mucus also appears to play an important role in the pro cess as it turns more alkaline in the second third of the cycle [5], and this facilitates the dissolution of ethynyl estradiol. This effect will occur even when ovulation is impeded.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, Cohen and Perez-Peldez [1] showed that ethynyl estradiol (EE2) causes the viscos ity to diminish, while Jeppsson and Kullander [2] found that progestogen contraceptives increase the viscosity of the cervical mucus. Ethynyl estradiol causes an increased spinnbarkeit, but this decreases in response to norethisterone acetate [5]. According to Mogh- 1 This work was supported in part by the WHO.…”

Section: Introductionmentioning

confidence: 99%

Ethynyl Estradiol Content of Cervical Mucus after Administration of Oral Contraceptive

Morvay¹,

Apró²,

Török³

1983

Horm Res

View full text Add to dashboard Cite

It was found by radioimmunoassay that the ethynyl estradiol concentration of the cervical mucus was 8.8 times higher than that of the serum in the first third of the cycle, 14 times higher in the second and 7.3 times higher in the third. The ethynyl estradiol content of the cervical mucus in the middle of the cycle showed a marked increase even when expressed as protein ratio. The accumulation of ethynyl estradiol in the cervical mucus is best demonstrated by the cervical mucus/serum ethynyl estradiol quotient of 9.7 found 12 h after oral administration of the contraceptive Bisecurin®.

show abstract

The tear ferning test: a simple clinical technique to evaluate the ocular tear film

Masmali

Purslow

Murphy

2014

Clinical and Experimental Optometry

View full text Add to dashboard Cite

A healthy tear film is very important for many major functions of the ocular surface. Dry eye disease is a significant clinical problem that needs to be solved but the poor correlation between clinical signs and reported symptoms makes it difficult for the clinician to apply a scientific basis to his clinical management. The problem is compounded by the difficulties of evaluating the tear film due to its transparency, small volume and complex composition. Practical insight into tear film composition would be very useful to the clinician for patient diagnosis and treatment but detailed analysis is restricted to expensive, laboratory-based systems. There is a pressing need for a simple test. The tear ferning test is a laboratory test but it has the potential to be applied in the clinic setting to investigate the tear film in a simple way. Drying a small sample of tear fluid onto a clean, glass microscope slide produces a characteristic crystallisation pattern, described as a 'tear fern'. This test is currently not widely used because of some limitations that need to be overcome but several studies have demonstrated its potential. Such limitations need to be resolved so that tear ferning could be used in the clinic setting to assess the tear film.

show abstract

Effects of norgestimate in combination with ethinyl estradiol on cervical mucus

Cited by 4 publications

References 4 publications

Effects of norgestimate (0.250 mg) in combination with ethinyl estradiol (0.035 mg) on cervical mucus

Effects of norgestimate (0.250 mg) in combination with ethinyl estradiol (0.035 mg) on cervical mucus

Ethynyl Estradiol Content of Cervical Mucus after Administration of Oral Contraceptive

The tear ferning test: a simple clinical technique to evaluate the ocular tear film

Contact Info

Product

Resources

About