Effects of Normobaric Hypoxia on Oxygen Saturation Variability

Costello, Joseph; Bhogal, Amar S.; Williams, Thomas B.; Bekoe, Richard; Sabir, Amin; Tipton, Michael J.; Corbett, Jo; Mani, Ali R.

doi:10.1089/ham.2019.0092

Cited by 19 publications

(36 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…SpO 2 is the physiological parameter which tracks the amount of oxygen dissolved in arterial blood or transported oxygen bound to hemoglobin, as indirectly measured at suitable peripheral sites (i.e., finger, toe, forehead, and ear) by pulse oximetry. Since the brain, as well as the muscles, requires a constant oxygen supply to support the high metabolic rate production necessary to remain electrically active (Williams et al, 2019 ), SpO 2 monitoring is of relevance to detect possible risk conditions not only in clinical settings, but also in physiological studies, sport science, and occupational medicine (Costello et al, 2020 ; Pham et al, 2020 ; Stensrud et al, 2020 ). A reduction in oxygen availability, as experienced at high altitudes or in particular challenging situations, can have a detrimental effect on brain and muscles function, inducing performance decline and increasing the risk of errors and injuries (Hoiland et al, 2016 ).…”

Section: Resultsmentioning

confidence: 99%

Hearables: New Perspectives and Pitfalls of In-Ear Devices for Physiological Monitoring. A Scoping Review

2020

View full text Add to dashboard Cite

Technological advancements are opening the possibility of prolonged monitoring of physiological parameters under daily-life conditions, with potential applications in sport science and medicine, and in extreme environments. Among emerging wearable technologies, in-ear devices or hearables possess technical advantages for long-term monitoring, such as non-invasivity, unobtrusivity, good fixing, and reduced motion artifacts, as well as physiological advantages related to the proximity of the ear to the body trunk and the shared vasculature between the ear and the brain. The present scoping review was aimed at identifying and synthesizing the available evidence on the use and performance of in-ear monitoring of physiological parameters, with focus on applications in sport science, sport medicine, occupational medicine, and extreme environment settings. Pubmed, Scopus, and Web of Science electronic databases were systematically searched to identify studies conducted in the last 10 years and addressing the measurement of three main physiological parameters (temperature, heart rate, and oxygen saturation) in healthy subjects. Thirty-nine studies were identified, 24 performing temperature measurement, 12 studies on heart/pulse rate, and three studies on oxygen saturation. The collected evidence supports the premise of in-ear sensors as an innovative and unobtrusive way for physiological monitoring during daily-life and physical activity, but further research and technological advancement are necessary to ameliorate measurement accuracy especially in more challenging scenarios.

show abstract

Section: Resultsmentioning

confidence: 99%

Hearables: New Perspectives and Pitfalls of In-Ear Devices for Physiological Monitoring. A Scoping Review

2020

View full text Add to dashboard Cite

show abstract

“…This study was part of a larger project investigating effects of normobaric hypoxia on physiological and cognitive function and the experimental design has been described in detail elsewhere (Costello et al, 2020;Williams et al, 2019…”

Section: Experimental Designmentioning

confidence: 99%

“…Participants' cardiorespiratory parameters, including (Costello et al, 2020). Thus, time series taken in the last 30 min were used for analysis in this study (i.e.…”

Section: Physiological Recordingmentioning

confidence: 99%

“…More recently, we have demonstrated that as the concentration of inspired oxygen (F IO 2 ) is decreased, S pO 2 entropy increases, and there is a strong significant negative correlation between mean S pO 2 and its entropy during normobaric hypoxic exposure (Costello et al, 2020). In addition, S pO 2 entropy, but not mean S pO 2 , was correlated with perception of breathlessness in otherwise healthy individuals when hypoxic (Costello et al, 2020).…”

mentioning

confidence: 96%

See 1 more Smart Citation

A network physiology approach to oxygen saturation variability during normobaric hypoxia

Jiang

Costello

Williams

et al. 2020

Experimental Physiology

Self Cite

View full text Add to dashboard Cite

Peripheral capillary oxygen saturation (S pO 2) exhibits a complex pattern of fluctuations during hypoxia. The physiological interpretation of S pO 2 variability is not well understood. In this study, we tested the hypothesis that S pO 2 fluctuation carries information about integrated cardio-respiratory control in healthy individuals using a network physiology approach. We explored the use of transfer entropy in order to compute the flow of information between cardio-respiratory signals during hypoxia. Twelve healthy males (mean (SD) age 22 (4) years) were exposed to four simulated environments (fraction of inspired oxygen (F IO 2): 0.12, 0.145, 0.17, and 0.2093) for 45 min, in a single blind randomized controlled design. The flow of information between different physiological parameters (S pO 2 , respiratory frequency, tidal volume, minute ventilation, heart rate, end-tidal pressure of O 2 and CO 2) were analysed using transfer entropy. Normobaric hypoxia was associated with a significant increase in entropy of the S pO 2 time series. The transfer entropy analysis showed that, particularly at F IO 2 0.145 and 0.12, the flow of information between S pO 2 and other physiological variables exhibits a bidirectional relationship. While reciprocal interactions were observed between different cardio-respiratory parameters during hypoxia, S pO 2 remained the main hub of this network. S pO 2 fluctuations during graded hypoxia exposure carry information about cardio-respiratory control. Therefore, S pO 2 entropy analysis has the potential for non-invasive assessment of the functional connectivity of respiratory control system in various healthcare settings. K E Y W O R D S altitude, hypoxic, sample entropy, S pO 2 , transfer entropy 1 INTRODUCTION Peripheral capillary oxygen saturation (S pO 2) is measured noninvasively and is extensively used for monitoring patients in clinical This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

show abstract

“…In addition, there was a large inter-individual variability for responses to environmental stresses, although we selected "moderate" hot and hypoxic environments. Hence, SpO 2 variability in healthy individuals increases substantially with the severity of simulated graded normobaric hypoxia for a wide range (12%-21%) of FiO 2 values (Costello et al, 2020) Furthermore, we did not monitor core temperature to evaluate the severity of heat stress during exercise. Therefore, caution is required when interpreting the present results.…”

Section: Limitationmentioning

confidence: 99%

Acute performance and physiological responses to repeated‐sprint exercise in a combined hot and hypoxic environment

et al. 2020

View full text Add to dashboard Cite

Team and racket sport athletes repeatedly produce brief bouts of maximal power output (~10 s) interspersed with insufficient recovery period (~60 s) during competition. This physical fitness component is known as "repeated-sprint ability" (RSA) (Bishop, Girard, & Mendez-Villanueva, 2011; Girard, Mendez-Villanueva, & Bishop, 2011). Recent studies have shown that several weeks of repeated-sprint training in hypoxia further improves RSA compared with the same

show abstract

Effects of Normobaric Hypoxia on Oxygen Saturation Variability

Cited by 19 publications

References 27 publications

Hearables: New Perspectives and Pitfalls of In-Ear Devices for Physiological Monitoring. A Scoping Review

Hearables: New Perspectives and Pitfalls of In-Ear Devices for Physiological Monitoring. A Scoping Review

A network physiology approach to oxygen saturation variability during normobaric hypoxia

Acute performance and physiological responses to repeated‐sprint exercise in a combined hot and hypoxic environment

Contact Info

Product

Resources

About