Effects of NSAIDs on the nanoscopic dynamics of lipid membrane

Sharma, V. K.; Mamontov, Eugene; Tyagi, Madhusudan

doi:10.1016/j.bbamem.2019.183100

Cited by 39 publications

(31 citation statements)

References 58 publications

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“…As the lateral motion of the lipid involves diffusion of the whole lipid within the leaflet and the internal motion of the lipid is localized, the AMPs affect mainly the lateral motion of the lipid. Comparing the results with other membrane active molecules such as NSAIDs (Sharma et al, 2019b(Sharma et al, , 2020, vitamins (Sharma et al, 2016a), cholesterol (Sharma et al, 2015b) etc., it can be concluded that effects of the membrane active molecules are correlated with the location of the molecules in the lipid membrane. If the additive molecules are located on the surface of the membrane it mainly affects the lateral motion of the lipid molecules.…”

Section: Internal Motionmentioning

confidence: 99%

“…These motions occur in a wide range of time scales ranging from vibrations at ∼fs to flip flop motions which take a few hours, and over a wide variety of length scales, from molecular rotations at a few Ås to the macroscopic deformation of the vesicles at the micrometer scale. To investigate these motions, various experimental methods have been used, such as dynamic light scattering (Hassan et al, 2015;Sharma et al, 2020), fluorescence spectroscopy (Machán and Hof, 2010;Singh et al, 2019), electron paramagnetic resonance (McConnell and Kornberg, 1971), nuclear magnetic resonance (Perlo et al, 2011), quasielastic neutron scattering (Busch et al, 2010;Armstrong et al, 2011;Sharma et al, 2015aSharma et al, , 2017aDubey et al, 2018;Sharma and Mukhopadhyay, 2018), neutron spin echo (Boggara et al, 2010;Lee et al, 2010;Woodka et al, 2012;Nickels et al, 2015). Each method has limited accessible temporal and spatial regimes.…”

Section: Introductionmentioning

confidence: 99%

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Enhanced Microscopic Dynamics of a Liver Lipid Membrane in the Presence of an Ionic Liquid

et al. 2020

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Ionic liquids (ILs) are an important class of emerging compounds, owing to their widespread industrial applications in high-performance lubricants for food and cellulose processing, despite their toxicity to living organisms. It is believed that this toxicity is related to their actions on the cellular membrane. Hence, it is vital to understand the interaction of ILs with cell membranes. Here, we report on the effects of an imidazolium-based IL, 1-decyl-3-methylimidazolium tetrafluoroborate (DMIM[BF4]), on the microscopic dynamics of a membrane formed by liver extract lipid, using quasielastic neutron scattering (QENS). The presence of significant quasielastic broadening indicates that stochastic molecular motions of the lipids are active in the system. Two distinct molecular motions, (i) lateral motion of the lipid within the membrane leaflet and (ii) localized internal motions of the lipid, are found to contribute to the QENS broadening. While the lateral motion could be described assuming continuous diffusion, the internal motion is explained on the basis of localized translational diffusion. Incorporation of the IL into the liver lipid membrane is found to enhance the membrane dynamics by accelerating both lateral and internal motions of the lipids. This indicates that the IL induces disorder in the membrane and enhances the fluidity of lipids. This could be explained on the basis of its location in the lipid membrane. Results are compared with various other additives and we provide an indication of a possible correlation between the effects of guest molecules on the dynamics of the membrane and its location within the membrane.

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Section: Internal Motionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Enhanced Microscopic Dynamics of a Liver Lipid Membrane in the Presence of an Ionic Liquid

et al. 2020

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“…1 Fatty acid and monoglyceride abbreviations: caproic acid (COA), caprylic acid (CYA), capric acid (CA), docosahexaenoic acid (DHA), lauric acid (LA), myristic acid (MA), palmitic acid (PA), stearic acid (SA), linolenic acid (LLA), glycerol monocaprate (GMC), and glycerol monolaurate (GML); 2 Liposomal formulations of LA, OA, SA, and LLA are denoted by LipoLA, LipoOA, LipoSA, and LipoLLA, respectively. 3 Egg PC = egg phosphatidylcholine; 4 DOPC = 1,2-dioleoyl-sn-glycero-3-phosphocholine; 5 PCL-PEG-PCL = poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone); 6 LNC was composed of poly-oxyl 15 hydroxy-stearate surfactant, lecithin, caprylic/capric acid triglycerides, and fatty acid or monoglyceride as a co-surfactant. 7 NLC was composed of a mixture of glyceryl palmitostearate, medium-chain triglycerides, Tween-60 surfactant, and DHA.…”

Section: Dha H Pylori (-)mentioning

confidence: 99%

“…DPPC = 1,2-dipalmitoyl-sn-glycero-3-phosphocholine 5. NLC oily phase comprised Tween 80, oleic acid, doxorubicin, triethanolamine, glyceryl di-behenate, and DHA; aqueous phase comprised EDTA and water 6. Both NEs and NLCs had poloxamer 188 as the aqueous phase within the nanoparticle design 7.…”

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confidence: 99%

Lipid Nanoparticle Technology for Delivering Biologically Active Fatty Acids and Monoglycerides

Tan

Yoon

Cho

et al. 2021

IJMS

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There is enormous interest in utilizing biologically active fatty acids and monoglycerides to treat phospholipid membrane-related medical diseases, especially with the global health importance of membrane-enveloped viruses and bacteria. However, it is difficult to practically deliver lipophilic fatty acids and monoglycerides for therapeutic applications, which has led to the emergence of lipid nanoparticle platforms that support molecular encapsulation and functional presentation. Herein, we introduce various classes of lipid nanoparticle technology and critically examine the latest progress in utilizing lipid nanoparticles to deliver fatty acids and monoglycerides in order to treat medical diseases related to infectious pathogens, cancer, and inflammation. Particular emphasis is placed on understanding how nanoparticle structure is related to biological function in terms of mechanism, potency, selectivity, and targeting. We also discuss translational opportunities and regulatory needs for utilizing lipid nanoparticles to deliver fatty acids and monoglycerides, including unmet clinical opportunities.

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“…[ 5 ]. Although the available OA treatments, including non-steroidal and steroidal drugs, have proven efficacies in alleviating pain and inflammation, the long-term uses of these drugs have severe health consequences such as cardiovascular, gastro-intestinal, and renal dysfunctions [ 6 ]. Thus, a more effective medicine with fewer side effects has to be developed for the treatment of osteoarthritis.…”

Section: Introductionmentioning

confidence: 99%

Analgesic and Anti-Inflammatory Effects of Aucklandia lappa Root Extracts on Acetic Acid-Induced Writhing in Mice and Monosodium Iodoacetate-Induced Osteoarthritis in Rats

Lee²,

Baek

et al. 2020

Plants

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Osteoarthritis (OA) is an age-related joint disease and one of the most common degenerative bone diseases among elderly people. The currently used therapeutic strategies relying on nonsteroidal anti-inflammatory drugs (NSAIDs) and steroids for OA are often associated with gastrointestinal, cardiovascular, and kidney disorders, despite being proven effective. Aucklandia lappa is a well-known traditional medicine. The root of A. lappa root has several bioactive compounds and has been in use as a natural remedy for bone diseases and other health conditions. We evaluated the A. lappa root extracts on OA progression as a natural therapeutic agent. A. lappa substantially reduced writhing numbers in mice induced with acetic acid. Monosodium iodoacetate (MIA) was injected into the rats through their knee joints of rats to induce experimental OA, which shows similar pathological characteristics to OA in human. A. lappa substantially reduced the MIA-induced weight-bearing of hind limb and reversed the cartilage erosion in MIA rats. IL-1β, a representative inflammatory mediator in OA, was also markedly decreased by A. lappa in the serum of MIA rats. In vitro, A. lappa lowered the secretion of NO and suppressed the IL-1β, COX-2, IL-6, and iNOS production in RAW264.7 macrophages activated with LPS. Based on its analgesic and anti-inflammatory effects, A. lappa could be a potential remedial agent against OA.

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Effects of NSAIDs on the nanoscopic dynamics of lipid membrane

Cited by 39 publications

References 58 publications

Enhanced Microscopic Dynamics of a Liver Lipid Membrane in the Presence of an Ionic Liquid

Enhanced Microscopic Dynamics of a Liver Lipid Membrane in the Presence of an Ionic Liquid

Lipid Nanoparticle Technology for Delivering Biologically Active Fatty Acids and Monoglycerides

Analgesic and Anti-Inflammatory Effects of Aucklandia lappa Root Extracts on Acetic Acid-Induced Writhing in Mice and Monosodium Iodoacetate-Induced Osteoarthritis in Rats

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