Effects of Nutritional Supplementation on Fatigue, and Autonomic and Immune Dysfunction in Patients with End-Stage Renal Disease: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial

Fukuda, Sanae; Koyama, Hideki; Kondo, Kazuhiro; Fujii, Hisako; Hirayama, Yukio; Tabata, Tsutomu; Okamura, Mitsu; Yamakawa, Tomoyuki; Okada, Shigeki; Hirata, Sumio; Kiyama, Hiroshi; Kajimoto, Osami; Watanabe, Yasuyoshi; Inaba, Masaaki; Nishizawà, Yoshiki

doi:10.1371/journal.pone.0119578

Cited by 39 publications

(21 citation statements)

References 32 publications

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“…Therefore, future studies should focus on identifying these factors as predictors of poor prognosis in ESRD. Since some studies ( 40 - 42 ) have already identified the importance of fatigue in terms of ESRD prognosis, it is also vital to identify possible mechanisms through which fatigue have toxic impact. It is not well known which interventions should focus on either physical fatigue, mental fatigue, or both.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Fatigue in End Stage Renal Disease Patients Undergoing Hemodialysis: Prevalence and Associated Factors

Zyga

Alikari

Sachlas

et al. 2015

Med Arh

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Background:Fatigue is a common symptom referred by many patients undergoing hemodialysis. Fatigue is associated with poor health-related quality of life (HRQoL) and is an important predictor for survival of hemodialysis patients.Aim:To assess the levels of fatigue and demographic factors affecting it among patients with End Stage Renal Disease undergoing hemodialysis.Methods:This quantitative study was carried out in two Dialysis Units of Hospitals in Athens Region. Between January 2015 and June 2015, 129 hemodialysis patients completed the Greek Version of the Fatigue Assessment Scale (FAS). Demographic data of patients was recorded. For the statistical analysis IBM SPSS Statistics version 20 was used.Results:The mean FAS score was 24.99. 49 patients (38.0%) were non fatigued, 61 patients (47.3%) were fatigued, and 19 patients (13.7%) were extremely fatigued. Higher levels of fatigue were reported among hemodialysis patients residing in urban areas, in those with low educational level and unemployed.Conclusion:The findings of this study can be used in the assessment of fatigue and early identification of high-risk patients (especially of the unemployed, those who occupy with domestic works, those with low educational level and of urban citizens). Use of this knowledge by hemodialysis nurses may lead to a better understanding of the factors of fatigue in ESRD, which in turn may lead to a more effective treatment.

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Section: Discussionmentioning

confidence: 99%

Assessment of Fatigue in End Stage Renal Disease Patients Undergoing Hemodialysis: Prevalence and Associated Factors

Zyga

Alikari

Sachlas

et al. 2015

Med Arh

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“…In this study, the intake of Euglena improved the autonomic nervous system balance, thereby improving irritability and tension as well as the quality of daily sleep. Previous studies have evaluated improvements in autonomic nervous system activity after nutritional supplementation in healthy subjects [ 37 , 38 , 39 , 40 ]. When stress is transmitted to the hypothalamus in the brain, a signal is sent to excite the autonomic nervous system, depending on the type of stress, and a command is simultaneously sent to the pituitary gland to stimulate the thyroid, adrenal medulla, and adrenal cortex via the release of hormones.…”

Section: Discussionmentioning

confidence: 99%

Effects of Euglena gracilis Intake on Mood and Autonomic Activity under Mental Workload, and Subjective Sleep Quality: A Randomized, Double-Blind, Placebo-Controlled Trial

Nakashima¹,

Yasuda²,

Murata³

et al. 2020

Nutrients

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While the human body maintains homeostasis by altering the balance in the autonomic nervous, endocrine, and immune systems, a prolonged imbalance in these systems can result in physical and mental symptoms, including a decline in sleep quality and work efficiency. Euglena gracilis (Euglena) is a single-celled microalga with the properties of both plants and animals and contains abundant nutrients, such as vitamins, minerals, amino acids, and fatty acids, which have various beneficial health effects. This study evaluated the effects of Euglena intake on the mood states and stress coping under mental workload tasks, and subjective sleep quality. We assigned men and women aged 20 to 64 years to Euglena and placebo intake groups, and measured indices related to the autonomic nervous system, psychological states, and sleep quality together with the application of workload stress before food intake, and 4, 8, and 12 weeks after commencing intake. Euglena intake regulated the autonomic nervous system under a workload and improved psychological parameters and sleep conditions. These results indicate that the consumption of Euglena may regulate the balance of the autonomic nervous system during stress and may have a favorable effect on psychological status and sleep quality.

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“…Suplementasi juga diperlukan karena dapat menstimulasi sistem imun disfungsi saraf autonomic pada pasien hemodialisis 10 agent (ESA) 11 . Vitamin B6 ini dipakai untuk sintesis hemoglobin, sehingga ESA dapat menyebabkan penurunan kadar eritrosit yang mengandung vitamin B6 1 .…”

Section: Hasil Dan Pembahasanunclassified

Asupan energi, zat gizi makro, dan zat gizi mikro pada pasien hemodialisis di RSUD Panembahan Senopati Bantul

Astuti

Septriana

2018

JNUTRI

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Latar belakang: Pasien Penyakit Ginjal Kronik (PGK) yang menjalani hemodialis memerlukan monitoring dan evaluasi asupan makan secara rutin. Rendahnya monitoring dan evaluasi pada asupan dapat berpengaruh pada status gizi dan kualitas hidup pasien. Tujuan: Mengetahui gambaran asupan energi, zat gizi makro, dan zat gizi mikro pada pasien hemodialisis di RSUD Panembahan Senopati Bantul. Metode: Penelitian ini merupakan penelitian deskriptif yang dilakukan di Unit Hemodialisis RSUD Panembahan Senopati Bantul. Pemilihan subjek penelitian menggunakan purposive sampling (n=30). Data asupan diambil dengan food recall 24 jam selama 3 hari. Hasil : Rerata asupan pada responden adalah : energi 1149,34±401,09 kcal (23,15±7,39 kcal/kgBB/hari); karbohidrat 143,55±43,46 g, protein 39,38±16,53 g (0,79±0,32 g/kgBB/hari); dan lemak 49,01±26,82 g. Rerata asupan vitamin B1 adalah 0,38±0,14 mg; vitamin B2 0,49±0,24 mg; vitamin B6 0,64±0,25 mg; asam folat 0,68±0,94 mg; vitamin C 24,08±21,01 mg; dan vitamin A 397,31±536,14 μg. Rerata asupan natrium natrium 22,45±220,23 mg; kalium 1714,01±1153,91 mg ( 36,64±27,40 mg/kgBB/hari); kalsium 301,13±173,23 mg; dan fosfor 544,94±193,08 mg. Kesimpulan : Rerata asupan energi, zat gizi makro, dan vitamin pada pasien hemodialis di RSUD Panembahan Senopati Bantul masih kurang dari rekomendasi, sedangkan asupan natrium, kalsium, dan fosfor sesuai dengan rekomendasi Perhimpunan Nefrologi Indonesia.

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Effects of Nutritional Supplementation on Fatigue, and Autonomic and Immune Dysfunction in Patients with End-Stage Renal Disease: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial

Cited by 39 publications

References 32 publications

Assessment of Fatigue in End Stage Renal Disease Patients Undergoing Hemodialysis: Prevalence and Associated Factors

Assessment of Fatigue in End Stage Renal Disease Patients Undergoing Hemodialysis: Prevalence and Associated Factors

Effects of Euglena gracilis Intake on Mood and Autonomic Activity under Mental Workload, and Subjective Sleep Quality: A Randomized, Double-Blind, Placebo-Controlled Trial

Asupan energi, zat gizi makro, dan zat gizi mikro pada pasien hemodialisis di RSUD Panembahan Senopati Bantul

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