Effects of obesity and diabetes on the epigenetic modification of mammalian gametes

Ou, Xiang‐Hong; Zhu, Chengcheng; Sun, Shao‐Chen

doi:10.1002/jcp.27847

Cited by 68 publications

(45 citation statements)

References 78 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, methylation-mediated epigenetic mechanisms for intergenerational susceptibility to metabolic disorders were found in a mouse model for GDM [104]. Epigenetic effects of obesity and diabetes on the offspring have in models been shown to occur not only at the fetus level, but also already in the oocyte and sperm [103][104][105][106] implying an influence of both maternal and paternal metabolic disorder [103][104][105][106][107]. Reported DNA methylation changes of maternal metabolic state with putative effects in the brain include, but are not limited to, those on offspring leptin signaling [93,108].…”

Section: Epigenetic Effects Of Maternal Obesity and Diabetesmentioning

confidence: 99%

Relationship of prenatal maternal obesity and diabetes to offspring neurodevelopmental and psychiatric disorders: a narrative review

et al. 2020

View full text Add to dashboard Cite

Obesity and diabetes is a worldwide public health problem among women of reproductive age. This narrative review highlights recent epidemiological studies regarding associations of maternal obesity and diabetes with neurodevelopmental and psychiatric disorders in offspring, and provides an overview of plausible underlying mechanisms and challenges for future human studies. A comprehensive search strategy selected terms that corresponded to the domains of interest (maternal obesity, different types of diabetes, offspring cognitive functions and neuropsychiatric disorders). The databases searched for articles published between January 2010 and April 2019 were PubMed, Web of Science and CINAHL. Evidence from epidemiological studies strongly suggests that maternal pre-pregnancy obesity is associated with increased risks for autism spectrum disorder, attention-deficit hyperactivity disorder and cognitive dysfunction with modest effect sizes, and that maternal diabetes is associated with the risk of the former two disorders. The influence of maternal obesity on other psychiatric disorders is less well studied, but there are reports of associations with increased risks for offspring depression, anxiety, schizophrenia and eating disorders, at modest effect sizes. It remains unclear whether these associations are due to intrauterine mechanisms or explained by confounding family-based sociodemographic, lifestyle and genetic factors. The plausible underlying mechanisms have been explored primarily in animal models, and are yet to be further investigated in human studies.

show abstract

Section: Epigenetic Effects Of Maternal Obesity and Diabetesmentioning

confidence: 99%

Relationship of prenatal maternal obesity and diabetes to offspring neurodevelopmental and psychiatric disorders: a narrative review

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Histone methylation has an immediate effect during fertilization; it exerts a positive effect on the embryonic S-phase and on subsequent preimplantation development [7,8]. It is now recognized that pathologies can be transmitted across generations via epimutations that occur in adult gametogenesis [59][60][61][62][63]. Oxidative stress plays a pivotal role in this process, with glucose, lipids, and homocysteine as well as chemicals at the center of the problem.…”

Section: Methylation Errors In the Malementioning

confidence: 99%

“…Diabetic patients have a high level of oxidative stress due to excess ROS generated by glucose metabolism at the level of the Krebs cycle (succinyl dehydrogenase) and inhibition of hypoxanthine-guanine phosophoribosyltransferase (HPRT). Although epigenetic disorders can be transmitted via sperm [6, 60,63], ROS may also affect the primary sperm DNA structure directly via the formation of DNA adducts such as 8-oxo deoxyguanosine: all of the nuclear bases may be affected by oxidation, but guanine is the most sensitive. The oocyte has a redundant but finite capacity for DNA repair, which decreases with maternal age [57,64].…”

Section: Methylation Errors In the Malementioning

confidence: 99%

Methylation: An Ineluctable Biochemical and Physiological Process Essential to the Transmission of Life

Ménézo¹,

Clément²,

Clément³

et al. 2020

IJMS

View full text Add to dashboard Cite

Methylation is a universal biochemical process which covalently adds methyl groups to a variety of molecular targets. It plays a critical role in two major global regulatory mechanisms, epigenetic modifications and imprinting, via methyl tagging on histones and DNA. During reproduction, the two genomes that unite to create a new individual are complementary but not equivalent. Methylation determines the complementary regulatory characteristics of male and female genomes. DNA methylation is executed by methyltransferases that transfer a methyl group from S-adenosylmethionine, the universal methyl donor, to cytosine residues of CG (also designated CpG). Histones are methylated mainly on lysine and arginine residues. The methylation processes regulate the main steps in reproductive physiology: gametogenesis, and early and late embryo development. A focus will be made on the impact of assisted reproductive technology and on the impact of endocrine disruptors (EDCs) via generation of oxidative stress.

show abstract

“…Найбільш вагомими факторами, що першочергово впливають на концентрацію тиреоїдних гормонів у сироватці крові, є активність їх обміну та транспортування (Scuderi et al, 2018;Ou et al, 2018). Існує тісний зв'язок між обмінами білків та тиреоїних гормонів, оскільки Т 4 і Т 3 майже стовідсотково зв'язуються з білками.…”

Section: вступunclassified

Clinical signs of hypothyroidism in domestic dogs

2020

View full text Add to dashboard Cite

The research was conducted during 2016–2019 on the basis of veterinary clinics in Poltava - veterinary clinic at the Department of Therapy named after Professor P.Lokes of Poltava State Agrarian Academy, “Vet Line”, “Vet Comfort” and the laboratory of the Department of Therapy named after Professor P. I. Lokes of Poltava State Agrarian Academy. During the research we studied 11 dogs, which were diagnosed with hypothyroidism. The animals belonged to different breeds, had different sexes (6 females and 5 males) and age. For control we took 15 dogs without visible signs of any pathology. We compared the breed susceptibility of dogs with hypothyroidism and dogs with alimentary obesity. Thus, we found that most breeds are common to animals in both pathologies. However, in our sample for hypothyroidism there was no such breed as a pug, and outbred individuals, which accounted for a significant percentage of dogs with alimentary obesity. One of the most common clinical symptom is the presence of symmetrical alopecia on the sides on the background of dull and disheveled hair (90.9 %). Mucosal anemia was observed in a significant proportion of animals (81.8 %). The symptom of bradycardia and shortness of breath during exercise is observed in 72.7 % of experimental animals, which indicates the development of pathological changes in the cardiovascular system. It was found that all animals showed depression, weakness and fatigue (100.0 %). Polydipsia and hypothermia were much less common in 45.5 % of dogs, and corneal dystrophy in 36.4% of cases. The last clinical manifestation occurred in animals with the most severe pathology. According to the literature, it is known that hypothyroidism in dogs is often a symptom of obesity. According to our data, obesity (overweight) was registered in 63.6 % of experimental animals. With the diagnosis of “hypothyroidism” in dogs, we identified two experimental groups: 1 – animals with normal fatness; 2nd – with a clinical symptom of obesity. We can note a significant increase in adipose tissue in dogs with hypothyroidism of the 2nd experimental group (45.1 ± 1.70 %), which indicates the presence of endocrine obesity, as evidenced by visual assessment of fatness (4.7 ± 0.18 points). Such changes develop due to insufficient production of thyroid hormones. The latter play an important role in regulating metabolism in the body. Due to their deficiency, the metabolism in animals slows down and, as a result, there is a risk of obesity.

show abstract

Effects of obesity and diabetes on the epigenetic modification of mammalian gametes

Cited by 68 publications

References 78 publications

Relationship of prenatal maternal obesity and diabetes to offspring neurodevelopmental and psychiatric disorders: a narrative review

Relationship of prenatal maternal obesity and diabetes to offspring neurodevelopmental and psychiatric disorders: a narrative review

Methylation: An Ineluctable Biochemical and Physiological Process Essential to the Transmission of Life

Clinical signs of hypothyroidism in domestic dogs

Contact Info

Product

Resources

About