Effects of octopamine on reproduction, juvenile hormone metabolism, dopamine, and 20‐hydroxyecdysone contents in <i>Drosophila</i>

Грунтенко, Н. Е.; Karpova, E. K.; Alekseev, A. A.; Chentsova, N. A.; Богомолова, Е. В.; Bownes, Mary; Rauschenbach, I. Yu.

doi:10.1002/arch.20187

Cited by 51 publications

(32 citation statements)

References 37 publications

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“…aegypti and Drosophila. In agreement with our observation of Drosophila larvae, Gruntenko et al [15] showed that an increased level of octopamine was related to a decreased number of vitellogenic (stages 8-10) and mature (stage 14) oocytes in Drosophila virilis as well as a decreased fecundity of D. melanogaster and D. virilis. Our observation that exposure to formamidine suppresses insect feeding is supported by a large body of evidence.…”

Section: Discussionsupporting

confidence: 90%

Unique biochemical and molecular biological mechanism of synergistic actions of formamidine compounds on selected pyrethroid and neonicotinoid insecticides on the fourth instar larvae of Aedes aegypti (Diptera: Culicidae)

Ahmed

Vogel

Matsumura

2015

Pesticide Biochemistry and Physiology

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Section: Discussionsupporting

confidence: 90%

Unique biochemical and molecular biological mechanism of synergistic actions of formamidine compounds on selected pyrethroid and neonicotinoid insecticides on the fourth instar larvae of Aedes aegypti (Diptera: Culicidae)

Ahmed

Vogel

Matsumura

2015

Pesticide Biochemistry and Physiology

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“…Three hormones interrelated by their canonical roles in morphogenesis are shown here to maintain their relationship despite dramatic reorganization of the body plan following metamorphosis. The diversity of allato-regulators in Drosophila, including insulin-like peptides and biogenic amines (40)(41)(42)(43), also influence JH production; each may influence this network in a context-specific manner to coordinate and optimize reproductive behaviors. The ability of the CA to integrate a variety of inputs, including nutrition and steroid levels, into a proreproductive signal bears a striking similarity to the mammalian GnRH neuron, which integrates complex hormonal information regarding stress, nutrition, and circadian rhythm into its activity, the emergent hormonal state determining whether reproduction is appropriate (44).…”

Section: Discussionmentioning

confidence: 99%

Endocrine network essential for reproductive success in Drosophila melanogaster

Meiselman

Lee

Tran

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

140

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Ecdysis-triggering hormone (ETH) was originally discovered and characterized as a molt termination signal in insects through its regulation of the ecdysis sequence. Here we report that ETH persists in adult Drosophila melanogaster, where it functions as an obligatory allatotropin to promote juvenile hormone (JH) production and reproduction. ETH signaling deficits lead to sharply reduced JH levels and consequent reductions of ovary size, egg production, and yolk deposition in mature oocytes. Expression of ETH and ETH receptor genes is in turn dependent on ecdysone (20E). Furthermore, 20E receptor knockdown specifically in Inka cells reduces fecundity. Our findings indicate that the canonical developmental roles of 20E, ETH, and JH during juvenile stages are repurposed to function as an endocrine network essential for reproductive success.ecdysis triggering hormone | ecdysone | juvenile hormone | fecundity | oogenesis T he life history of insects is characterized by radical morphogenetic transformations, whereby tissues are reorganized and hormones are repurposed for roles associated with stage-specific functions. During development, larvae complete each molt by shedding the cuticle under control of ecdysis triggering hormones (ETHs) targeting central peptidergic ensembles to orchestrate an innate behavioral sequence (1-3). Previous observations that Inka cells, the sole source of ETHs, persist into the adult stage (4) suggest possible reproductive functions for these peptides.We hypothesized that ETHs regulate juvenile hormone (JH) levels, based on the report of ETH receptor (ETHR) expression in the corpora allata (CA) of the silkworm, Bombyx mori (5). Evidence that ETH functions as an allatotropin in the yellow fever mosquito Aedes aegypti came from a recent study showing its activation of JH acid methyltransferase (6).JH is a sesquiterpenoid hormone with well-known morphogenetic and gonadotropic functions. In Drosophila, adult phenotypes resulting from reduction of JH levels have been characterized through induction of cell death in the CA or through enhancement of its degradation (7,8). Based on evidence from studies on Bombyx and Aedes, we investigated whether ETH functions as an allatotropin in adult Drosophila and the extent to which it may be necessary for reproductive functions.Previous studies showed that ecdysone (20E) regulates synthesis and release of ETH and expression of ETHR during larval stages of moths and mosquitoes (9-12). More recently, selftranscribing active regulatory region sequencing (STARR-Seq) data confirm that 20E induces 20E receptor (EcR) enhancer activity in promoters of both ETH and ETHR genes (13). Because circulating 20E levels are of major physiological and reproductive relevance (14), we also asked whether 20E influences ETH gene expression during the adult stage.Here we describe functional roles for 20E, ETH, and JH as a hormonal triad essential for reproductive success in Drosophila.In particular, we confirm persistence of ETH signaling throughout adulthood and demonstrate it...

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“…Octopamine may also act as a neurohormone in controlling the metabolism of gonadotropins (juvenile hormone and 20-H ecdysone; Gruntenko et al 2007). dVMAT mutants show an eggretention phenotype similar to mutants with reduced octopamineric signaling.…”

Section: Discussionmentioning

confidence: 99%

Drosophila Vesicular Monoamine Transporter Mutants Can Adapt to Reduced or Eliminated Vesicular Stores of Dopamine and Serotonin

et al. 2009

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Physiologic and pathogenic changes in amine release induce dramatic behavioral changes, but the underlying cellular mechanisms remain unclear. To investigate these adaptive processes, we have characterized mutations in the Drosophila vesicular monoamine transporter (dVMAT), which is required for the vesicular storage of dopamine, serotonin, and octopamine. dVMAT mutant larvae show reduced locomotion and decreased electrical activity in motoneurons innervating the neuromuscular junction (NMJ) implicating central amines in the regulation of these activities. A parallel increase in evoked glutamate release by the motoneuron is consistent with a homeostatic adaptation at the NMJ. Despite the importance of aminergic signaling for regulating locomotion and other behaviors, adult dVMAT homozygous null mutants survive under conditions of low population density, thus allowing a phenotypic characterization of adult behavior. Homozygous mutant females are sterile and show defects in both egg retention and development; males also show reduced fertility. Homozygotes show an increased attraction to light but are mildly impaired in geotaxis and escape behaviors. In contrast, heterozygous mutants show an exaggerated escape response. Both hetero-and homozygous mutants demonstrate an altered behavioral response to cocaine. dVMAT mutants define potentially adaptive responses to reduced or eliminated aminergic signaling and will be useful to identify the underlying molecular mechanisms.A MINERGIC signaling pathways regulate a variety of complex behaviors in both the fly and mammals. In Drosophila melanogaster, dopamine is thought to regulate arousal (van Swinderen et al.

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Effects of octopamine on reproduction, juvenile hormone metabolism, dopamine, and 20‐hydroxyecdysone contents in Drosophila

Cited by 51 publications

References 37 publications

Unique biochemical and molecular biological mechanism of synergistic actions of formamidine compounds on selected pyrethroid and neonicotinoid insecticides on the fourth instar larvae of Aedes aegypti (Diptera: Culicidae)

Unique biochemical and molecular biological mechanism of synergistic actions of formamidine compounds on selected pyrethroid and neonicotinoid insecticides on the fourth instar larvae of Aedes aegypti (Diptera: Culicidae)

Endocrine network essential for reproductive success in Drosophila melanogaster

Drosophila Vesicular Monoamine Transporter Mutants Can Adapt to Reduced or Eliminated Vesicular Stores of Dopamine and Serotonin

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