Effects of Oleuropein on Serum Inflammatory Cytokines
and Histopathological Changes in Rats with Pancreatitis

Çağlayan, Kasım; Güngör, Bülent; Çınar, Hamza; Avcı, Bahattin; Gur, Sebnem; Arslan, Nilden

doi:10.17219/acem/40453

Cited by 6 publications

(8 citation statements)

References 19 publications

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“…Data recorded in vivo for an OLE-mediated effect on circulating IL-6 led to inconclusive results. In an in vivo model of acute pancreatitis, OLE showed no prophylactic effect in terms of reduction in serum IL-6 [89], but in LPS-induced sepsis [80], in cyclophosphamide and epirubicin combined treatment toxicity [90], in myocardial ischemia/reperfusion [81], and in experimental autoimmune myocarditis [91], an OLE anti-inflammatory effect manifested in part as a decrease in IL-6 serum level. An analogous reduction in plasma IL-6 levels was mediated by OLE in a model of sepsis-induced myocardial injury [92].…”

Section: Il-6mentioning

confidence: 99%

“…An analogous reduction in plasma IL-6 levels was mediated by OLE in a model of sepsis-induced myocardial injury [92]. In the limits of biological differences of used animals and experimental models, discrepant results cannot be explained in terms of the variability of the administered doses, since in acute pancreatitis, experimental autoimmune myocarditis, and sepsis-induced myocardial injury models, researchers employed a 20 mg/kg dose of OLE, with 25 and 50 mg/kg doses used only in LPS-induced sepsis [80,89,91,92].…”

Section: Il-6mentioning

confidence: 99%

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Effects of Oleuropein and Hydroxytyrosol on Inflammatory Mediators: Consequences on Inflammaging

Pojero

Aiello

Gervasi

et al. 2022

IJMS

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Aging is associated with a low-grade, systemic inflammatory state defined as “inflammaging”, ruled by the loss of proper regulation of the immune system leading to the accumulation of pro-inflammatory mediators. Such a condition is closely connected to an increased risk of developing chronic diseases. A number of studies demonstrate that olive oil phenolic compound oleuropein and its derivative hydroxytyrosol contribute to modulating tissue inflammation and oxidative stress, thus becoming attractive potential candidates to be used in the context of nutraceutical interventions, in order to ameliorate systemic inflammation in aging subjects. In this review, we aim to summarize the available data about the anti-inflammatory properties of oleuropein and hydroxytyrosol, discussing them in the light of molecular pathways involved in the synthesis and release of inflammatory mediators in inflammaging.

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Section: Il-6mentioning

confidence: 99%

Section: Il-6mentioning

confidence: 99%

Effects of Oleuropein and Hydroxytyrosol on Inflammatory Mediators: Consequences on Inflammaging

Pojero

Aiello

Gervasi

et al. 2022

IJMS

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“…The underlying mechanisms of inflammation and necrosis are not fully understood, but it has generally been recognized that activated leukocytes play a significant role in the pathogenesis of inflammation. Serum concentrations of pro-inflammatory cytokines, such as tumor necrosis factor α, and interleukins, such as interleukin-1 beta (IL-1), interleukin-6 (IL-6), and interleukin-8 (IL-8), were significantly higher in severe pancreatitis compared with mild pancreatitis [ 27 , 28 ].…”

Section: Acute Pancreatitismentioning

confidence: 99%

The Cause and Effect Relationship of Diabetes after Acute Pancreatitis

2023

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Acute pancreatitis (AP) is an acute inflammation of the pancreas associated with high morbidity and mortality. Endocrine pancreatic insufficiency secondary to AP has drawn increasing attention in recent years. The aim of this paper is to analyze the available clinical and experimental literature to determine the cause and effect relationship of diabetes type 3c (T3cDM; pancreatogenic diabetes) after acute pancreatitis. The clinico-pathological features and management challenges of pancreatogenic diabetes overlap with other secondary causes of diabetes. A complex pathogenesis involving pancreatic exocrine insufficiency, dysfunction of insulin secretion, and insulin resistance is likely the cause of T3cDM after AP. To obtain an improved understanding of the pathophysiology of diabetes after AP, more research is now needed to understand the risk of complications related to the pancreas and diabetes in these patients.

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“…Oleuropein (23) is a glycosylated seco-iridoid obtained from Olea europaea L., and has been shown to produce antioxidant, anti-atherosclerotic, and anti-inflammatory activities (Impellizzeri et al, 2011b). Several studies have reported that oleuropein can attenuate the levels of pro-inflammatory cytokines in various experimental models such as carrageenan-induced pleurisy, DSS (dextran sulfate sodium)-induced chronic colitis (Giner et al, 2011), doxorubicin-induced cardiomyopathy (Andreadou et al, 2014), myocardial infarction (Janahmadi et al, 2015) and BPDO (bile-pancreatic duct obstruction)-induced pancreatitis (Caglayan et al, 2015). Impellizzeri et al, (Impellizzeri et al, 2011a), showed that oleuropein significantly attenuated the release of TNF-α and IL-1β in the pleural exudates in a carrageenan-induced pleurisy model.…”

Section: Iridoid Glycosidesmentioning

confidence: 99%

Monoterpenes modulating cytokines - A review

Quintans

Saravanan

Heimfarth

et al. 2019

Food and Chemical Toxicology

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Inflammatory response can be driven by cytokine production and is a pivotal target in the management of inflammatory diseases. Monoterpenes have shown that promising profile as agents which reduce the inflammatory process and also modulate the key chemical mediators of inflammation, such as pro and anti-inflammatory cytokines. The main interest focused on monoterpenes were to develop the analgesic and anti-inflammatory drugs. In this review, we summarized current knowledge on monoterpenes that produce anti-inflammatory effects by modulating the release of cytokines, as well as suggesting that which monoterpenoid molecules may be most effective in the treatment of inflammatory disease. Several different inflammatory markers were evaluated as a target of monoterpenes. The proinflammatory and antiinflammatory cytokines were found TNF-α, IL-1β, IL-2, IL-5, IL-4, IL-6, IL-8, IL-10, IL-12 IL-13, IL-17A, IFNγ, TGF-β1 and IFN-γ. Our review found evidence that NF-κB and MAPK signaling are important pathways for the anti-inflammatory action of monoterpenes. We found 24 monoterpenes that modulate the production of cytokines, which appears to be the major pharmacological mechanism these compounds possess in relation to the attenuation of inflammatory response. Despite the compelling evidence supporting the anti-inflammatory effect of monoterpenes, further studies are necessary to fully explore their potential as anti-inflammatory compounds.

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Effects of Oleuropein on Serum Inflammatory Cytokines and Histopathological Changes in Rats with Pancreatitis

Abstract: The experimental model used in this study showed to be appropriate for creation of acute pancreatitis. It was concluded that oleuropein as a prophylactic treatment has no protective effect on serum proinflammatory and anti-inflammatory cytokines as well as pancreatic tissue.

Cited by 6 publications

References 19 publications

Effects of Oleuropein and Hydroxytyrosol on Inflammatory Mediators: Consequences on Inflammaging

Effects of Oleuropein and Hydroxytyrosol on Inflammatory Mediators: Consequences on Inflammaging

The Cause and Effect Relationship of Diabetes after Acute Pancreatitis

Monoterpenes modulating cytokines - A review

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