Effects of oleuropein on tumor cell growth and bone remodelling: Potential clinical implications for the prevention and treatment of malignant bone diseases

Leto, Gaetano; Flandina, Carla; Crescimanno, Maria; Giammanco, Marco; Sepporta, Maria Vittoria

doi:10.1016/j.lfs.2020.118694

Cited by 5 publications

(8 citation statements)

References 172 publications

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“…Because several of these pathways are linked to the epithelial–mesenchymal transition [ 41 ], evidence of Ole’s ability in preventing osteoporosis has led to the hypothesis that Ole can also prevent bone cancer proliferation [ 6 ]. Ole can influence numerous pathways, including wnt/-catenin [ 41 ] and MMP and their inhibitors, as well as upstream activators of NF-kB [ 42 ] such as mitogen-activated protein kinases (p38 MAPK), extracellular signal-regulated kinase (ERK), and AKT [ 43 ]. Therefore, it is possible that Ole can prevent bone tumor formation by altering the tumor microenvironment [ 41 ].…”

Section: Role Of Ole In Cancermentioning

confidence: 99%

“…Ole can influence numerous pathways, including wnt/-catenin [ 41 ] and MMP and their inhibitors, as well as upstream activators of NF-kB [ 42 ] such as mitogen-activated protein kinases (p38 MAPK), extracellular signal-regulated kinase (ERK), and AKT [ 43 ]. Therefore, it is possible that Ole can prevent bone tumor formation by altering the tumor microenvironment [ 41 ]. The properties of the tumor microenvironment, or premetastatic niche, are significant aspects of cancer [ 44 ].…”

Section: Role Of Ole In Cancermentioning

confidence: 99%

“…This persistent inflammation as well as the proinflammatory cytokines IL-1 and IL-6 promote tumor formation in lung and breast cancer models [ 42 ]. Many proinflammatory cytokines, including IL-6, IL-8, IL-1, and TNF-, have been identified as altering bone tumor angiogenesis, progression, and tumor microenvironment [ 41 ]. One of the most important properties of a premetastatic niche is inflammation [ 45 ].…”

Section: Role Of Ole In Cancermentioning

confidence: 99%

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A Comprehensive Review on the Anti-Cancer Effects of Oleuropein

Rishmawi

Haddad

Dokmak

2022

Life

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In Mediterranean cuisine and culture, olive oil and olive fruits play a significant role. Many people believe that those who consume olive oil and its fruit live longer and have a decreased risk of illness. Olive leaves were used to treat a range of diseases in ancient times, including malaria fever and lower earaches. Although it was not understood at the time what key components were responsible for these effects because they had not yet been discovered, Oleuropein is now recognized as one of the primary elements in immature olive fruits and leaves. Later research was carried out to determine the effects of this molecule, and it was determined that it functions as an antioxidant. Oleuropein consumption has aided in cancer treatment over the years, and this was assumed to be owing to its antioxidant properties. Oleuropein’s effects on cancer, however, go beyond that; it is now known that Oleuropein functions as both an anti-proliferative and an apoptotic promoter in many cancer cells. The kinetics and dosages of Oleuropein and the mechanisms behind its involvement and effects in cancer are explored in this review. Finally, the effects of Oleuropein in combination with anticancer medicines are investigated.

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Section: Role Of Ole In Cancermentioning

confidence: 99%

Section: Role Of Ole In Cancermentioning

confidence: 99%

Section: Role Of Ole In Cancermentioning

confidence: 99%

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A Comprehensive Review on the Anti-Cancer Effects of Oleuropein

Rishmawi

Haddad

Dokmak

2022

Life

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“…Cancer Seçme et al, 2016;Capo et al, 2017;Sherif, Al-Gayyar, 2018;Ruzzolini e al., 2018;;Nicolin et al, 2019;Torić et al, 2019;Przychodzen et al,2019a;Przychodzen et al, 2019b;Castejón et al, 2020;Leto et al, 2020;Asgharzade et al, 2021;Hamed et al, 2021;Ramírez-Expósito et al, 2021.…”

Section: Cholesterolmentioning

confidence: 99%

“…Many studies provide evidence on the effectiveness of oleuropein in preventing and treating various pathologies associated with bone loss (Leto et al, 2020). In which these effects are related to the activity of oleuropein in modulating several common signaling molecules contained in the pathogenesis of malignant and non-malignant bone diseases.…”

Section: Hypertensionmentioning

confidence: 99%

Leaves of Olea europaea L. as a source of oleuropein: characteristics and biological aspects

Otero¹,

Lorini

Oliveira

et al. 2021

RSD

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Olive fruits, leaves and derived virgin oils are known to be good sources of polyphenols and other antioxidants that have recently received increasing interest. In addition, its derivatives are responsible for the bitter and spicy taste of green olive fruits and virgin olive oils. In the physiology of the olive plant, the enzymatic biotransformation of oleuropein is related to fruit ripening and the tissue-specific defense mechanism. The oleuropein is one of the main phenolic compounds identified in fruits and olive leaves. It has several pharmacological properties, including antioxidant, cardioprotective, anti-heterogeneous, neuropathic, anti-cancer and other effects. Oleuropein is slightly absorbed after oral administration and reaches a maximum plasma concentration, being widely distributed in various organs and tissues, including the heart, liver and brain. In view of recent studies on the use oleuropein obtained from olive leaves in the treatment and prevention of diseases, this work was carried out with the aim of compiling the main information available in the literature through this review.

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