Effects of Olibanum extracts on the collagenase activity and procollagen synthesis in Hs68 human fibroblasts and tyrosinase activity

Leem, Kang Hyun

doi:10.14257/astl.2015.88.36

Cited by 8 publications

(6 citation statements)

References 3 publications

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“…It induces activator protein-1 (AP-1), a transcription factor that promotes collagen breakdown by up regulating enzymes called matrix metalloproteinases (MMPs). Overexpression of matrix metalloproteinase (MMP-1, MMP-3 and MMP-9) leads to elevated levels of degraded collagen (Leem, 2015). Also, UV radiation causes downregulation of transforming growth factor ␤ (TGF-␤), a cytokine that promotes pro-collagen production thus causing reduced collagen synthesis (Fig.…”

Section: Skin Agingmentioning

confidence: 99%

Mushrooms extracts and compounds in cosmetics, cosmeceuticals and nutricosmetics—A review

Taofiq

González-Paramás

Martins

et al. 2016

Industrial Crops and Products

158

114

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a b s t r a c tThe cosmetic industry is constantly in search of ingredients from natural sources because of their competitive effectiveness and lower toxicity effects. Mushrooms have been an important part of our diet for years and are now finding their way as cosmetic ingredients, either as cosmeceutical or as nutricosmetics. The present review focuses on the most relevant activities of mushroom extracts, as well as on their bioactive compounds, which make them interesting ingredients for cosmetic formulations. Mushroom extracts, as well as their bioactive metabolites, revealed anti-tyrosinase, anti-hyaluronidase, anti-collagenase and anti-elastase activity. Emphasis was also given to their important anti-oxidant, antimicrobial and antiinflammatory potential, topics largely studied by numerous authors, making them very versatile and multi-functional cosmetic ingredients. Some of the bioactive compounds and the mechanism responsible for the activities ascribed to mushrooms were highlighted. Other activities were identified as needing to be further studied in order to identify the major compounds contributing to the target activity, as well as their mechanisms of action. Based on the above findings, mushroom extracts, as well as their bioactive metabolites, constitute important ingredients that can help to combat aging, reduce the severity of inflammatory skin disease and correct hyperpigmentation disorders. These findings and claims must be correctly supported by clinical trials and in vivo studies.

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Section: Skin Agingmentioning

confidence: 99%

Mushrooms extracts and compounds in cosmetics, cosmeceuticals and nutricosmetics—A review

Taofiq

González-Paramás

Martins

et al. 2016

Industrial Crops and Products

158

114

View full text Add to dashboard Cite

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“…Skin aging is caused by an intrinsic or natural mechanism affecting the skin and other body organs related to hormonal changes occurring with age, and by extrinsic mechanisms associated with ultraviolet radiation exposure, which causes free radical species generation [1]. Reactive oxygen species (ROS) are responsible for inducing the activator protein-1 (AP-1), a transcription factor that promotes collagen and elastin breakdown by up regulation of the matrix metalloproteinases (MMPs) [2]. This environmental stress generated from ROS and reactive nitrogen species (RNS), combined with increased secretion of inflammatory mediators and enzyme expression (e.g., collagenase and elastase), causes inflammation and decreases the tensile strength and elasticity of the skin [3].…”

Section: Introductionmentioning

confidence: 99%

Development of Mushroom-Based Cosmeceutical Formulations with Anti-Inflammatory, Anti-Tyrosinase, Antioxidant, and Antibacterial Properties

et al. 2016

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Abstract:The cosmetic industry is in a constant search for natural compounds or extracts with relevant bioactive properties, which became valuable ingredients to design cosmeceutical formulations. Mushrooms have been markedly studied in terms of nutritional value and medicinal properties. However, there is still slow progress in the biotechnological application of mushroom extracts in cosmetic formulations, either as antioxidants, anti-aging, antimicrobial, and anti-inflammatory agents or as hyperpigmentation correctors. In the present work, the cosmeceutical potential of ethanolic extracts prepared from Agaricus bisporus, Pleurotus ostreatus, and Lentinula edodes was analyzed in terms of anti-inflammatory, anti-tyrosinase, antioxidant, and antibacterial activities. The extracts were characterized in terms of phenolic acids and ergosterol composition, and further incorporated in a base cosmetic cream to achieve the same bioactive purposes. From the results obtained, the final cosmeceutical formulations presented 85%-100% of the phenolic acids and ergosterol levels found in the mushroom extracts, suggesting that there was no significant loss of bioactive compounds. The final cosmeceutical formulation also displayed all the ascribed bioactivities and as such, mushrooms can further be exploited as natural cosmeceutical ingredients.

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“…However, the FoxO is rendered inactive by the AKT pathway, which prevents the cell's production of antioxidant enzymes. Activator protein-1 (AP-1) and NF-κB are both nuclear proteins that MAPK regulates, and the expression of MMP is caused by AP-1 stimulation [46]. MMPs are a group of extracellular proteinases that include zinc that breaks down extracellular substances, including collagen and elastic fibers, which results in the development of wrinkles [46,47].…”

Section: Skin Agingmentioning

confidence: 99%

Natural Sun-Screening Compounds and DNA-Repair Enzymes: Photoprotection and Photoaging

Gupta

Singh

et al. 2023

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Ultraviolet radiation (UVR) has been scientifically proven to cause skin disorders such as sunburn, skin cancer and the symptoms of chronic exposure. Natural sun screening compounds have recently gained tremendous attention from the cosmetic and cosmeceutical sectors for treating skin disorders such as hyperpigmentation and aging. A wide range of natural UV-absorbing compounds have been used to replace or reduce the number of synthetic sunscreen molecules. One of the primary causes of photoaging is DNA damage, mainly caused by UVR. Photoprotection provided by traditional sunscreens is purely preventative and has no efficacy after DNA damage has been initiated. As a result, the quest for DNA-repair mechanisms that block, reverse, or postpone pathologic processes in UV-exposed skin has stimulated anti-photoaging research and methods to increase the effectiveness of traditional sunscreens. This review summarizes many natural compounds from microalgae, lichens, and plants that have demonstrated potential photoprotection effects against UV radiation-induced skin damage. Furthermore, it offers an overview of current breakthroughs in DNA-repair enzymes utilized in sunscreens and their influence on photoaging.

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Effects of Olibanum extracts on the collagenase activity and procollagen synthesis in Hs68 human fibroblasts and tyrosinase activity

Cited by 8 publications

References 3 publications

Mushrooms extracts and compounds in cosmetics, cosmeceuticals and nutricosmetics—A review

Mushrooms extracts and compounds in cosmetics, cosmeceuticals and nutricosmetics—A review

Development of Mushroom-Based Cosmeceutical Formulations with Anti-Inflammatory, Anti-Tyrosinase, Antioxidant, and Antibacterial Properties

Natural Sun-Screening Compounds and DNA-Repair Enzymes: Photoprotection and Photoaging

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