Effects of omega-3 fatty acids on working memory in rats with increased sugar intake

Ruhland, Stefanie; Hauser, Joachim; Kaunzinger, Ivo; Nakamura, Yukiko; Stollberg, Ewelina; Lange, Klaus W.

doi:10.1016/j.jff.2020.103951

Cited by 4 publications

(3 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Animal studies have provided consistent evidence supporting a link between reduced brain levels of DHA and altered performance in behavioral and cognitive tasks (Hauser et al, 2018;Lange et al, 2018;Lange, 2020c;Ruhland et al, 2020). In particular, preclinical experiments have demonstrated that a diet deficient in omega-3 fatty acids induces depressive-like and abnormal social behavior in rodents (Bondi et al, 2014;Lafourcade et al, 2011;Larrieu et al, 2014;Larrieu et al, 2016).…”

Section: Animal Studiesmentioning

confidence: 88%

Are omega-3 fatty acids efficacious in the treatment of depression? A review

Lange¹,

Nakamura²,

Zhao³

et al. 2021

Journal of Food Bioactives

Self Cite

View full text Add to dashboard Cite

The hypothesis that omega-3 fatty acids may play a role in preventing and treating depression is based on correlative associations between fish consumption, omega-3 fatty acid intake and the prevalence of major depressive disorder. Reduced omega-3 fatty acid erythrocyte levels have been found in individuals with depressive disorders. These observational findings are unable to establish a causal relationship between omega-3 fatty acids and depression. The results of randomized controlled trials of omega-3 fatty acids for depressive disorders are inconclusive and also fail to prove causation. The therapeutic efficacy of omega-3 fatty acids appears to be moderate at best but is more likely to be minimal or non-existent. Potential long-term adverse effects of omega-3 fatty acid supplementation should be considered. Large-scale, well-controlled clinical trials are required to establish potential anti-depressive effects of omega-3 fatty acids. Such studies need to consider baseline values of omega-3 fatty acids and symptom severity, the dosage and types of the fatty acids used, the duration of supplementation and the concomitant use of medication. Conclusive evidence of the efficacy of omega-3 fatty acids in depression is currently lacking. The recommendation of potentially ineffective therapies may have considerable opportunity costs, with other possibly more useful treatments remaining unutilized.

show abstract

Section: Animal Studiesmentioning

confidence: 88%

Are omega-3 fatty acids efficacious in the treatment of depression? A review

Lange¹,

Nakamura²,

Zhao³

et al. 2021

Journal of Food Bioactives

Self Cite

View full text Add to dashboard Cite

show abstract

“…It lowers the blood pressure, prevents cardiovascular diseases, diabetes, cancer, reduces Alzheimer's disease and dementia, normalizes cholesterol levels, reduces LDL (low-density lipoprotein) cholesterol, and increases HDL (high-density lipoprotein) cholesterol. The American Heart Association recommends eating fish at least two times per week as part of a healthy diet [5,9,[13][14][15][16][17][18][19][20][21]. Regardless of their known health benefits, fish and other seafood may represent a risk to human health due to the bioaccumulation and biomagnification of contaminants through the food chain.…”

Section: Introductionmentioning

confidence: 99%

Distribution and Bioaccumulation of Essential and Toxic Metals in Tissues of Thaila (Catla catla) from a Natural Lake, Pakistan and Its Possible Health Impact on Consumers

Saleem

Iqbal

Shi

et al. 2022

JMSE

View full text Add to dashboard Cite

Although fish are often recommended as a component of a healthy diet, the environmental accumulation of heavy metals in many fish species has been of considerable concern for those weighing the nutritional health benefits against adverse toxic outcome of excess intake of toxic metals. This study aimed to determine the concentration of essential and toxic metals in the tissues of Catla catla in Mangla Lake and to assess the possible risk to the consumers. Fifty samples of Catla catla were collected from Mangla Lake, Mirpur, Azad Jammu and Kashmir, Pakistan and analyzed for eighteen metals including essential and trace metals. The measured range concentrations (µg/g, wet weight) in muscle tissues, in decreasing order, were: K (955–1632), Ca (550–2081), Na (449–896), Mg (129–312), Zn (61.2–215), Fe (11.6–26.8), Sr (2.60–9.27), Pb (1.72–7.81), Se (1.55–3.55), Co (0.12–4.08), Mn (1.04–4.33), Ni (0.69–3.06), Cu (0.88–2.78), Cr (0.45–1.88), As (0.67–1.58), Cd (0.28–0.56), Hg (0.17–0.57) and Li (0.12–0.38). The metal concentrations found in this study were comparatively higher than those reported in literature. A majority of the metals exhibited higher accumulation in gills compared with those in scales and muscles. Mean levels of Pb, As, Co, Mn, Cd, Cr and Zn in Catla catla muscle were found to be exceeding the international permissible limits for the safe human consumption. The condition factor (K), as an indicator of fish health status, indicated that Catla catla of Mangla Lake are in good health condition. The metal pollution index (MPI) of gills (27.9), scales (12.5) and muscle (7.57) indicated low contamination. Moreover, human health risk was evaluated using estimated weekly intake (EWI) and daily intake (EDI), target hazard quotient (THQ), hazard index (HI) and target cancer risk (TCR). Estimated weekly and daily intake values for As, Cd, Cr, Hg, Ni and Pb were higher than provisional permissible tolerable weekly intake and permissible tolerable daily intake while THQ for As, Cd, Cr, Hg, Pb, Se and Zn was higher than 1. The THQ for As, Hg and Pb was several folds higher than 1, indicative of lifetime non-carcinogenic health risks to the consumers. The hazard index indicated cumulative risk, which greatly increased with increasing fish consumption. Target cancer risk indicated that the people eating the Catla catla from Mangla Lake were exposed to As, Cd, Cr, Ni and Pb with a significant lifetime carcinogenic risk. In summary, consumption of Catla catla from this lake was found to be associated with an increased lifetime risk to the general health of the consumers.

show abstract

“…The oil of marine origin are a source of nutrients such as fatty acids (Innes and Calder, 2020), squalene (Lozano-Grande et al, 2018), alkylglycerols (Deniau et al, 2010;Iannitti and Palmieri, 2010), among others. The fatty acid has a positively effect on the health, which action on the depression and anxiety symptoms (Deane et al, 2019), cholesterol in blood (DiNicolantonio and O'Keefe, 2018; Harris et al, 2018;Oteng and Kersten, 2020;Stonehouse et al, 2020), cardiovascular diseases (Sanders, 2019;Innes and Calder, 2020;Li et al, 2020), vascular effects (Hamadate et al, 2015), diabetes (Chewcharat et al, 2020), memory (Ruhland et al, 2020), among others (Simopoulos, 2020).…”

Section: Introductionmentioning

confidence: 99%

Development and validation of a gas chromatography with a flame ionization detector method for quantitative analysis of four major fatty acids extracted shark liver oil

Quero-Jiménez¹,

Felipe²,

Rodríguez³

et al. 2021

J Pharm Pharmacogn Res

View full text Add to dashboard Cite

Context: The shark liver of the species Ginglimostoma cirratun, Carcharhinus longimanus, and Carcharhinus falciformis, captured in the north-central coast of Cuba are a source of oil, whose content of major fatty acids could be used in its quality control. Aims: To develop a simple and robust gas chromatography with a flame ionization detector (GC-FID) method that is suitable for routine analysis of four major fatty acids extracted shark liver oil. Methods: Four major fatty acid content in shark liver oil pool of species Ginglimostoma cirratun, Carcharhinus longimanus, and Carcharhinus falciformis, was analyzed through the gas chromatography with a GC-FID. The fatty acids were analyzed as methyl esters derivatives, using 5% aqueous sulfuric acid in methanol. The method was validated in terms of linearity, precision, accuracy, specificity and limit of detection and quantitation. Results: Under the optimum analytical conditions, the analysis revealed that each target component was well separated with satisfactory recoveries and reproducibility. The method linearity was found to be high with good determination coefficient values for all target components. The evaluation of the matrix effect, demonstrated, that there is not interference from substances other than analysis. The method was also found to be accurate, precise and reproducible and it was applied to the quantitative determination of the fatty acid content in shark liver oil pool; oleic acid was the most abundant fatty acid (22.69%), followed by palmitic (18.85%), stearic (6.01 %) and myristic acid (0.40 %). Conclusions: The GC-FID developed method is reliable and suitable for determination of four major fatty acids in shark liver oil pool.

show abstract

Effects of omega-3 fatty acids on working memory in rats with increased sugar intake

Cited by 4 publications

References 33 publications

Are omega-3 fatty acids efficacious in the treatment of depression? A review

Are omega-3 fatty acids efficacious in the treatment of depression? A review

Distribution and Bioaccumulation of Essential and Toxic Metals in Tissues of Thaila (Catla catla) from a Natural Lake, Pakistan and Its Possible Health Impact on Consumers

Development and validation of a gas chromatography with a flame ionization detector method for quantitative analysis of four major fatty acids extracted shark liver oil

Contact Info

Product

Resources

About