Effects of omega-3 polyunsaturated fatty acids on fibrosis, endothelial function and myocardial performance, in ischemic heart failure patients

Oikonomou, Evangelos; Vogiatzi, Georgia; Karlis, Dimitrios; Siasos, Gerasimos; Chrysοhoou, Christina; Zografos, Theodoros; Lazaros, George; Tsalamandris, Sotirios; Mourouzis, Konstantinos; Georgiopoulos, Georgios; Toutouza, Marina; Tousoulis, Dimitris

doi:10.1016/j.clnu.2018.04.017

Cited by 49 publications

(38 citation statements)

References 34 publications

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“…If the relative composition of FFA content in the heart can influence inflammatory responses, and affect cardiac dysfunction, then dietary PUFAs may prevent pathological levels of pro-inflammatory cytokines (Wen et al, 2011; Oikonomou et al, 2018), and cardiac dysfunction in patients with metabolic disorders. Moreover, PUFAs have been shown to decrease secretion of TNF-α, IL-1β, and IL-6 through a pathway involving M2 anti-inflammatory macrophages (Lyons et al, 2016).…”

Section: Molecular Signaling Pathways Of Cardiolipotoxicity That Prommentioning

confidence: 99%

Cardiolipotoxicity, Inflammation, and Arrhythmias: Role for Interleukin-6 Molecular Mechanisms

2019

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Fatty acid infiltration of the myocardium, acquired in metabolic disorders (obesity, type-2 diabetes, insulin resistance, and hyperglycemia) is critically associated with the development of lipotoxic cardiomyopathy. According to a recent Presidential Advisory from the American Heart Association published in 2017, the current average dietary intake of saturated free-fatty acid (SFFA) in the US is 11–12%, which is significantly above the recommended <10%. Increased levels of circulating SFFAs (or lipotoxicity) may represent an unappreciated link that underlies increased vulnerability to cardiac dysfunction. Thus, an important objective is to identify novel targets that will inform pharmacological and genetic interventions for cardiomyopathies acquired through excessive consumption of diets rich in SFFAs. However, the molecular mechanisms involved are poorly understood. The increasing epidemic of metabolic disorders strongly implies an undeniable and critical need to further investigate SFFA mechanisms. A rapidly emerging and promising target for modulation by lipotoxicity is cytokine secretion and activation of pro-inflammatory signaling pathways. This objective can be advanced through fundamental mechanisms of cardiac electrical remodeling. In this review, we discuss cardiac ion channel modulation by SFFAs. We further highlight the contribution of downstream signaling pathways involving toll-like receptors and pathological increases in pro-inflammatory cytokines. Our expectation is that if we understand pathological remodeling of major cardiac ion channels from a perspective of lipotoxicity and inflammation, we may be able to develop safer and more effective therapies that will be beneficial to patients.

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Section: Molecular Signaling Pathways Of Cardiolipotoxicity That Prommentioning

confidence: 99%

Cardiolipotoxicity, Inflammation, and Arrhythmias: Role for Interleukin-6 Molecular Mechanisms

2019

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“…Data from GISSI-Heart Failure Trial show that administration of ω3-PUFA is associated with decreased total mortality in HF patients [ 19 ]. Moreover, short-term administration of ω3-PUFAs was revealed to improve both echocardiographic systolic markers and inflammatory and fibrosis biomarkers in these patients [ 20 ]. Finally, the importance of lipid-to-carbohydrate ratio in HF progression and prognosis has also been shown, since, according to experimental data, high fat and low-carbohydrate consumption increases the arrhythmic death risk, highlighting the need for a balanced fat and sugars intake, and avoidance of processed sugars [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

The effect of diet, lifestyle and psychological factors in the prognosis of ischemic heart failure

et al. 2019

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Background/Objective Dietary patterns may play an important role in the prognosis of heart failure. Methods Dietary habits, sleeping habits, physical activity and anxiety and depression status were recorded in 326 patients (90 females, mean age 73.45 ± 10.9 years) with ischemic heart failure prospectively followed for 30 months. Results Lower ΗADS-depression scores (p = 0.03), a low-fat meat diet (p = 0.035) and moderate coffee consumption (p = 0.005) were associated with better prognosis. Non-significant differences were recorded in outcomes with regard to consumption of other dietary categories. Conclusions A balanced diet as well as emphasis on the treatment of depression may improve outcomes in ischemic heart failure.

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“…In epidemiology studies and clinical trials, n-3 PUFA supplementation prevents the development of atherosclerotic diseases [ 211 , 212 ]. Moreover, n-3 PUFA supplementation has been shown to improve endothelial function in patients with primary antiphospholipid syndrome [ 213 ], type 2 diabetes [ 214 ], peripheral arterial disease [ 215 ], heart failure [ 216 ], and hypertriglyceridemia [ 217 ].…”

Section: Diet Effect On Endothelial Function and Oxidative Stressmentioning

confidence: 99%

Impact of Lifestyles (Diet and Exercise) on Vascular Health: Oxidative Stress and Endothelial Function

Man

Xia

2020

Oxidative Medicine and Cellular Longevity

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Healthy lifestyle and diet are associated with significant reduction in risk of obesity, type 2 diabetes, and cardiovascular diseases. Oxidative stress and the imbalance between prooxidants and antioxidants are linked to cardiovascular and metabolic diseases. Changes in antioxidant capacity of the body may lead to oxidative stress and vascular dysfunction. Diet is an important source of antioxidants, while exercise offers many health benefits as well. Recent findings have evidenced that diet and physical factors are correlated to oxidative stress. Diet and physical factors have debatable roles in modulating oxidative stress and effects on the endothelium. Since endothelium and oxidative stress play critical roles in cardiovascular and metabolic diseases, dietary and physical factors could have significant implications on prevention of the diseases. This review is aimed at summarizing the current knowledge on the impact of diet manipulation and physical factors on endothelium and oxidative stress, focusing on cardiovascular and metabolic diseases. We discuss the friend-and-foe role of dietary modification (including different diet styles, calorie restriction, and nutrient supplementation) on endothelium and oxidative stress, as well as the potential benefits and concerns of physical activity and exercise on endothelium and oxidative stress. A fine balance between oxidative stress and antioxidants is important for normal functions in the cells and interfering with this balance may lead to unfavorable effects. Further studies are needed to identify the best diet composition and exercise intensity.

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Effects of omega-3 polyunsaturated fatty acids on fibrosis, endothelial function and myocardial performance, in ischemic heart failure patients

Cited by 49 publications

References 34 publications

Cardiolipotoxicity, Inflammation, and Arrhythmias: Role for Interleukin-6 Molecular Mechanisms

Cardiolipotoxicity, Inflammation, and Arrhythmias: Role for Interleukin-6 Molecular Mechanisms

The effect of diet, lifestyle and psychological factors in the prognosis of ischemic heart failure

Impact of Lifestyles (Diet and Exercise) on Vascular Health: Oxidative Stress and Endothelial Function

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