Effects of Onosma armeniacum root extract on ethanol-induced oxidative stress in stomach tissue of rats

Çadırcı, Elif; Süleyman, Halis; Aksoy, Hülya; Halıcı, Zekai; Ozgen, Ufuk; Koç, Ayşegül; Öztürk, Nurınnısa

doi:10.1016/j.cbi.2007.06.040

Cited by 91 publications

(70 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This study shows that all treatments with famotidine (20mg/kg) and moclobemide (10,20,40,80, 150 mg/kg) also increased the GSH content significantly. When administered in the absence of an indomethacin dose, this affected the antioxidant defence system positively and reduced gastric damage.…”

Section: Discussionsupporting

confidence: 50%

“…In addition, the effect of moclobemide on oxidant and antioxidant parameters in rat stomach tissue was evaluated. Experimental results of this study show that moclobemide decreased the indomethacin-induced ulcers significantly at all doses used (10,20,40,80 and 150 mg/kg doses). The antiulcer effect of famotidine, a strong H2 receptor antagonist, was compared to that of moclobemide.…”

Section: Discussionmentioning

confidence: 59%

See 1 more Smart Citation

Investigation of Antiulcer and Antioxidant Activity of Moclobemide in Rats

Albayrak¹,

Hakan²,

Süleyman³

2015

EAJM

Self Cite

View full text Add to dashboard Cite

Objective: Even though there are many drugs for the treatment of gastric ulcers, these drugs sometimes cannot succeed. Since the 1950s, antidepressant drugs have been used for several non-psychiatric indications. Many antidepressant drugs have been shown experimentally to produce antiulcer activity in various ulcer models. Moclobemide is an antidepressant drug which inhibits monoamine oxidase-A (MAO) enzyme selectively. When it is compared to the classic antidepressants drugs, moclobemide is the first choice in depression treatment because of its effectiveness and less side effects. This study aimed to investigate the antiulcer effects of moclobemide and to determine its relationship with antioxidant mechanisms in rat gastric tissue. Materials and Methods:The antiulcer activities of 10, 20, 40, 80, 150 mg/kg moclobemide and 20 mg/kg famotidine have been investigated on indomethacin-induced ulcers in rats, and the results have been compared with that of the control group. Results:Moclobemide decreased the indomethacin-induced ulcers significantly at all doses used. While used doses of moclobemide increased the glutathione (GSH), nitric oxide (NO) level and superoxide dismutase (SOD) activity, it decreased the malondialdehyde (MDA) level and myeloperoxidase (MPO) activity in stomach tissue when compared to the control group. Conclusion:It is determined that an antidepressant drug, moclobemide is a potent anti-ulcer agent. Inhibition of toxic oxidant radicals and activation of antioxidant mechanisms play a role in its antiulcer effect mechanisms.

show abstract

Section: Discussionsupporting

confidence: 50%

Section: Discussionmentioning

confidence: 59%

Investigation of Antiulcer and Antioxidant Activity of Moclobemide in Rats

Albayrak¹,

Hakan²,

Süleyman³

2015

EAJM

Self Cite

View full text Add to dashboard Cite

show abstract

“…The anti-ulcerative effects of metyrosine were also investigated using an ethanol-induced ulcer model in rats [6,23]. Metyrosine was administrated intraperitoneally to rats fasted for 24 h at doses of 50, 100 or 200 mg/kg.…”

Section: Ethanol-induced Ulcer Testmentioning

confidence: 99%

Gastric anti-ulcerative and anti-inflammatory activity of metyrosine in rats

Albayrak

Polat

Çadırcı

et al. 2010

Pharmacological Reports

Self Cite

View full text Add to dashboard Cite

Abstract:In this study, the anti-inflammatory and anti-ulcerative effects of metyrosine, a selective tyrosine hydroxylase enzyme inhibitor, were investigated in rats. For ulcer experiments, indomethacin-induced gastric ulcer tests and ethanol-induced gastric ulcer tests were used. For these experiments, rats were fasted for 24 h. Different doses of metyrosine and 25 mg/kg doses of ranitidine were administered to rats, followed by indomethacin at 25 mg/kg for the indomethacin-induced ulcer test, or 50% ethanol for the ethanolinduced test. Results have shown that at all of the doses used (50, 100 and 200 mg/kg), metyrosine had significant anti-ulcerative effects in both indomethacin and ethanol-induced ulcer tests. Metyrosine doses of 100 and 200 mg/kg (especially the 200 mg/kg dose) also inhibited carrageenan-induced paw inflammation even more effectively than indomethacin. In addition, to characterize the anti-inflammatory mechanism of metyrosine we investigated its effects on cyclooxygenase (COX) activity in inflammatory tissue (rat paw). The results showed that all doses of metyrosine significantly inhibited high COX-2 activity. The degree of COX-2 inhibition correlated with the increase in anti-inflammatory activity. In conclusion, we found that metyrosine has more anti-inflammatory effects than indomethacin and that these effects can be attributed to the selective inhibition of COX-2 enzymes by metyrosine. We also found that adrenalin levels are reduced upon metyrosine treatment, which may be the cause of the observed gastro-protective effects of this compound.

show abstract

“…To scavenge reactive oxygen species (ROS), the human body has a complex system of natural enzymatic and non-enzymatic antioxidants including superoxide dismutase (SOD), reduced glutathione (GSH) and catalase (CAT), however, excessive generation of ROS enhances lipid peroxides (LPO) and could deplete these antioxidant enzymes [1]. Protection against free radicals can be enhanced by ample intake of dietary antioxidants.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Activity Assessment of Tamus Communis L. Roots

Zerargui

Baghiani

Khennouf

et al. 2016

Int J Pharm Pharm Sci

View full text Add to dashboard Cite

Objective: The aim of this study was to evaluate the antioxidant activities of Tamus communis L. (T. communis) roots. This plant is used in folk medicine in the treatment of rheumatism, arthritis and lumbago. Methods:The extraction of polyphenols has been followed by the determination of total polyphenols and flavonoids. The methanol extract (MeOHE) was chromatographied on a silica gel column. The column was eluted with chloroform and then with chloroform/methanol mixtures of increasing polarity, 6 main fractions (FI--FVI)) were collected and grouped according to their TLC (Thin layer chromatography). Several methods were used to evaluate the in vitro antioxidant activity such as DPPH (2, 2'-diphenyl-1-picrylhydrazy), bleaching of β-carotene for 24 h, lipid peroxidation and anti-hemolytic activity. An in vivo approach was carried out on mice treated with CE (crud extract) at a dose of 100 mg/Kg/day for 21 consecutive days, and one group was treated with vitamin C (Vit C 50 mg/kg) as a standard drug. To determine the improvement of antioxidant potential, basic biochemical parameters were used in tissue (liver), plasma and whole blood. Results:The results showed that the highest level of polyphenols was recorded in FII (73.143±0.009 mg GA-Eq/g extract (Gallic Acid Equivalent))/g of extract) followed by MeOHE (69.786±0.10 mg GA-Eq/g extract). Total flavonoid contents of extracts/fractions showed that MeOHE contains the highest level. Inhibition of DPPH radical showed that MeOHE (0.1187±0.025 mg/ml) and CE (0.2363±0.019 mg/ml) have the most efficient antioxidant activity. All the extracts were capable of inhibiting the bleaching of β-carotene by scavenging linoleate derived free radicals, and all the studied extracts have a very important antihemolytic activity (p<0.001) and revealed an extension of hemolysis half time from 70.34±2.15 min of CTL (AAPH (2,2-azo-bis (2-amidinopropane) dihydrochloride)) and 207±5.65 min for FI. The in vivo assay was exhibited a significant decrease (54.09%) of the content of malondialdehyde (MDA) in the liver and increased glutathione (GSH) and catalase (47.30% and 46.87% respectively). Conclusion:These findings suggest that the extract obtained from T. communis have active substances contributing to the increase in natural antioxidant potential.

show abstract

Effects of Onosma armeniacum root extract on ethanol-induced oxidative stress in stomach tissue of rats

Cited by 91 publications

References 38 publications

Investigation of Antiulcer and Antioxidant Activity of Moclobemide in Rats

Investigation of Antiulcer and Antioxidant Activity of Moclobemide in Rats

Gastric anti-ulcerative and anti-inflammatory activity of metyrosine in rats

Antioxidant Activity Assessment of Tamus Communis L. Roots

Contact Info

Product

Resources

About