Effects of Opisthorchis viverrini infection on glucose and lipid profiles in human hosts: A cross-sectional and prospective follow-up study from Thailand

Radhakrishnan, M.; Suttiprapa, Sutas; Mairiang, Eimorn; Kessomboon, Pattapong; Laha, Thewarach; Smith, John F.; Sripa, Banchob

doi:10.1016/j.parint.2019.102000

Cited by 20 publications

(40 citation statements)

References 34 publications

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“…Direct comparison showed that infection with trematode flukes [Schistosoma spp. (45,(51)(52)(53) and O. viverrini (46)] had a greater effect on all measures compared to infection with intestinal nematode parasites [S. stercoralis (49,50) and soil transmitted helminths (26)].…”

Section: Discussionmentioning

confidence: 99%

“…Of the fourteen studies assessed, nine reported that infection with a parasitic worm had protective effects on diabetes-related parameters (26,(44)(45)(46)(47)(50)(51)(52)(53), however three studies (48,49,55) reported a positive association between specific infections and T2D diagnosis, and two studies (54,56) reported no association. Individual glucose homeostasis related outcomes are summarized in Supplementary Table 4.…”

Section: Study Findingsmentioning

confidence: 98%

“…While six studies measured HbA1c, only three of those provided sufficient data for inclusion in a meta-analysis (46,50,52). Two of these studies examined the effect of infection with trematode parasites (46,52), and one examined infection with an intestinal nematode (50). Either an active infection with O. viverrini (46) or a previous infection with Schistosoma spp (52).…”

Section: Association Between Parasite Infection and Hba1cmentioning

confidence: 99%

“…Two of these studies examined the effect of infection with trematode parasites (46,52), and one examined infection with an intestinal nematode (50). Either an active infection with O. viverrini (46) or a previous infection with Schistosoma spp (52). reported significantly lowered HbA1c.…”

Section: Association Between Parasite Infection and Hba1cmentioning

confidence: 99%

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The Impact of Helminth Infection on the Incidence of Metabolic Syndrome: A Systematic Review and Meta-Analysis

et al. 2021

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BackgroundThere are a growing number of publications that report an absence of inflammatory based disease among populations that are endemic to parasitic worms (helminths) demonstrating the ability of these parasites to potentially regulate human immune responses. The aim of this systematic review and meta-analysis was to determine the impact of helminth infection on metabolic outcomes in human populations.MethodsUsing PRISMA guidelines, six databases were searched for studies published up to August 2020. Random effects meta-analysis was performed to estimate pooled proportions with 95% confidence intervals using the Review Manager Software version 5.4.1.ResultsFourteen studies were included in the review. Fasting blood glucose was significantly lower in persons with infection (MD -0.22, 95% CI -0.40- -0.04, P=0.02), HbA1c levels were lower, although not significantly, and prevalence of the metabolic syndrome (P=0.001) and type 2 diabetes was lower (OR 1.03, 95% CI 0.34-3.09, P<0.0001). Infection was negatively associated with type 2 diabetes when comparing person with diabetes to the group without diabetes (OR 0.44, 95% CI 0.29-0.67, P=0.0001).ConclusionsWhile infection with helminths was generally associated with improved metabolic function, there were notable differences in efficacy between parasite species. Based on the data assessed, live infection with S. mansoni resulted in the most significant positive changes to metabolic outcomes.Systematic Review RegistrationWebsite: PROSPERO Identified: CRD42021227619.

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Section: Discussionmentioning

confidence: 99%

Section: Study Findingsmentioning

confidence: 98%

Section: Association Between Parasite Infection and Hba1cmentioning

confidence: 99%

Section: Association Between Parasite Infection and Hba1cmentioning

confidence: 99%

See 2 more Smart Citations

The Impact of Helminth Infection on the Incidence of Metabolic Syndrome: A Systematic Review and Meta-Analysis

et al. 2021

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“…viverrini infection had a protective effect against hyperglycemia and risk of metabolic disease. However, serum levels of HbA1c and HDL significantly increased during the six months following PQZ treatment [ 34 ]. In addition, a study among high-risk subjects for CCA who were diagnosed with periductal fibrosis (PDF) by ultrasonography found that DM had a protective effect against PDF [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Association of comorbidity between Opisthorchis viverrini infection and diabetes mellitus in the development of cholangiocarcinoma among a high-risk population, northeastern Thailand

et al. 2021

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Background Cholangiocarcinoma (CCA) is a category of lethal hepatobiliary malignancies. Previous studies have found that Opisthorchis viverrini infection and diabetes mellitus (DM) are closely correlated with CCA. However, few studies have discussed the association of CCA with a combination of both O. viverrini infection and DM. This study aimed to assess the correlation of CCA with various combinations of O. viverrini infection and DM among a high-risk population in northeastern Thailand. Methodology This study included participants from 20 provinces in northeastern Thailand who had been screened for CCA in the Cholangiocarcinoma Screening and Care Program (CASCAP) between 2013 and 2019. Histories of O. viverrini infection and DM diagnosis were obtained using a health questionnaire. CCA screening used ultrasonography with a definitive diagnosis based on histopathology. Multilevel mixed-effects logistic regression was performed to quantify the association, which is presented as adjusted odds ratios (aOR) and their 95% confidence intervals (CI). Principal findings Overall, 263,776 participants were included, of whom 32.4% were infected with O. viverrini, 8.2% were diagnosed with DM, and 2.9% had a history of both O. viverrini infection and DM. The overall rate of CCA was 0.36%. Of those infected with O. viverrini, 0.47% had CCA; among those with DM, 0.59% had CCA and among those infected with O. viverrini and had DM, 0.73% had CCA. Compared with participants who were not infected with O. viverrini and were non-DM, the aOR for those infected with O. viverrini and with DM was 2.36 (95% CI: 1.74–3.21; p-value <0.001). Conclusions The combination of O. viverrini infection and DM was highly associated with CCA, and these two conditions had a combined effect on this association that was greater than that of either alone. These findings suggest that CCA screening should have a strong focus on people with a combination of O. viverrini infection and DM.

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The effects of helminth infections against type 2 diabetes

Gao

Zhang

et al. 2021

Parasitol Res

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Effects of Opisthorchis viverrini infection on glucose and lipid profiles in human hosts: A cross-sectional and prospective follow-up study from Thailand

Cited by 20 publications

References 34 publications

The Impact of Helminth Infection on the Incidence of Metabolic Syndrome: A Systematic Review and Meta-Analysis

The Impact of Helminth Infection on the Incidence of Metabolic Syndrome: A Systematic Review and Meta-Analysis

Association of comorbidity between Opisthorchis viverrini infection and diabetes mellitus in the development of cholangiocarcinoma among a high-risk population, northeastern Thailand

The effects of helminth infections against type 2 diabetes

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