Effects of Oral Administration of CrCl3 on the Contents of Ca, Mg, Mn, Fe, Cu, and Zn in the Liver, Kidney, and Heart of Chicken

Liu, Yanhan; Zhao, Xiaona; Zhang, Xiao; Zhao, Xuejun; Liu, Yongxia; Liu, Jianzhu

doi:10.1007/s12011-015-0559-1

Cited by 7 publications

(3 citation statements)

References 35 publications

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“…In relation to the mechanism, Cr 3+ is mainly related to blood glucose homeostasis and is an active component factor of glucose tolerance (GTF), which regulates blood glucose concentration, including carbohydrate and lipid metabolism ( 107 , 108 ). In addition, Cr 3+ complexes have been used to treat type 2 diabetes as insulin amplifiers ( 109 ).…”

Section: Discussionmentioning

confidence: 99%

Relationships Between Biological Heavy Metals and Breast Cancer: A Systematic Review and Meta-Analysis

et al. 2022

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IntroductionHeavy metals were classified as essential, probably essential, and potentially toxic in the general population. Until now, it has been reported inconsistently on the association between heavy metals and BC. In this meta-analysis, we aimed to assess the association between heavy metals and BC and review the potential mechanisms systematically.MethodsWe searched for epidemiological studies in English about the association between heavy metals and BC published before September 2020 in PubMed, Web of Science, and Embase databases. In total 36 studies, comprising 4,151 individuals from five continents around the world were identified and included.ResultsIn all biological specimens, Cu, Cd, and Pb concentrations were higher, but Zn and Mn concentrations were lower in patients with BC than in non-BC participants [SMD (95% CIs): 0.62 (0.12, 1.12); 1.64 (0.76, 2.52); 2.03 (0.11, 3.95); −1.40 (−1.96, −0.85); −2.26 (−3.39, −1.13); p = 0.01, 0.0003, 0.04, <0.0001, <0.0001]. Specifically, higher plasma or serum Cu and Cd, as well as lower Zn and Mn, were found in cases [SMD (95% CIs): 0.98 (0.36, 1.60); 2.55 (1.16, 3.94); −1.53 (−2.28, −0.78); −2.40 (−3.69, −1.10); p = 0.002, 0.0003, <0.0001, 0.0003]; in hair, only lower Zn was observed [SMD (95% CIs): −2.12 (−3.55, −0.68); p = 0.0004]. Furthermore, the status of trace elements probably needs to be re-explored, particularly in BC. More prospective studies, randomized clinical trials, and specific pathogenic studies are needed to prevent BC. The main mechanisms underlying above-mentioned findings are comprehensively reviewed.ConclusionFor BC, this review identified the current knowledge gaps which we currently have in understanding the impact of different heavy metals on BC.Systematic Review Registrationwww.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020176934, identifier: CRD42020176934.

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Section: Discussionmentioning

confidence: 99%

Relationships Between Biological Heavy Metals and Breast Cancer: A Systematic Review and Meta-Analysis

et al. 2022

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“…Cr(III) is an active component in the glucose tolerance factor (GTF), and plays a significant role in regulating blood-glucose levels, involving the processes of carbohydrate and lipid metabolism. 22 , 23 Furthermore, Cr(III) complexes were previously used as insulin enhancers for the treatment of type 2 diabetes. 24 However, recently studies have revealed that Cr(III) compounds can lead to DNA damage.…”

Section: Introductionmentioning

confidence: 99%

Carcinogenicity of chromium and chemoprevention: a brief update

Song

et al. 2017

OTT

206

103

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Chromium has two main valence states: hexavalent chromium (Cr[VI]) and trivalent chromium (Cr[III]). Cr(VI), a well-established human carcinogen, can enter cells by way of a sulfate/phosphate anion-transport system, and then be reduced to lower-valence intermediates consisting of pentavalent chromium (Cr[V]), tetravalent chromium (Cr[IV]) or Cr(III) via cellular reductants. These intermediates may directly or indirectly result in DNA damage or DNA–protein cross-links. Although Cr(III) complexes cannot pass easily through cell membranes, they have the ability to accumulate around cells to induce cell-surface morphological alteration and result in cell-membrane lipid injuries via disruption of cellular functions and integrity, and finally to cause DNA damage. In recent years, more research, including in vitro, in vivo, and epidemiological studies, has been conducted to evaluate the genotoxicity/carcinogenicity induced by Cr(VI) and/or Cr(III) compounds. At the same time, various therapeutic agents, especially antioxidants, have been explored through in vitro and in vivo studies for preventing chromium-induced genotoxicity/carcinogenesis. This review aims to provide a brief update on the carcinogenicity of Cr(VI) and Cr(III) and chemoprevention with different antioxidants.

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“…For example, excessive intake of Cr(III) may disrupt the absorption of trace elements in the serum and brain (Liu et al, 2017). Cr accumulates in large quantities in the heart, liver, and kidneys over a long period of time and leads to impaired metal absorption and metabolism in chickens (Liu et al, 2016). Oral administration of CrCl 3 can reduce the growth performance of chickens, cause pathological lesions such as renal tubular atrophy and structural degeneration of the glomerulus, and affect the antioxidant capacity of the kidney (Liu et al, 2015).…”

Section: Accumulative Poisoningmentioning

confidence: 99%

Toxicity mechanisms and remediation strategies for chromium exposure in the environment

Yan

Ying-jun

Xue

et al. 2023

Front. Environ. Sci.

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Chromium (Cr) is the seventh most abundant chemical element in the Earth’s crust, and Cr(III) and Cr(VI) are common stable valence states of Cr. Several Cr-containing substances, such as FeOCr2O3 and stainless-steel products, exist in nature and in life. However, Cr(VI) is toxic to soil, microorganisms, and plants and poses a serious threat to human health through direct and indirect exposure. By collecting published journal literature, we found that Cr(VI) can cause acute and chronic toxicity in organisms and has carcinogenic effects, and the mechanisms causing these toxicity include endoplasmic reticulum stress, autophagy and apoptosis. However, the relationship between these mechanisms remains unclear. Many methods have been researched to purify chromium, but each of these methods has its own advantages and disadvantages. Therefore, this review summarizes the hazards of chromium and the mechanisms of chromium toxicity after entering cells and provides a number of methods for chromium contamination management, providing a direction for the next step in chromium toxicology and contamination decontamination research.

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Effects of Oral Administration of CrCl3 on the Contents of Ca, Mg, Mn, Fe, Cu, and Zn in the Liver, Kidney, and Heart of Chicken

Cited by 7 publications

References 35 publications

Relationships Between Biological Heavy Metals and Breast Cancer: A Systematic Review and Meta-Analysis

Relationships Between Biological Heavy Metals and Breast Cancer: A Systematic Review and Meta-Analysis

Carcinogenicity of chromium and chemoprevention: a brief update

Toxicity mechanisms and remediation strategies for chromium exposure in the environment

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