Effects of oral erythrosine (2′,4′,5′,7′-tetraiodofluorescein) on the pituitary-thyroid axis in rats

Health safety issues of synthetic food colorants

“…In an experiment evaluating reproductive toxicity in rats, it was found that Erythrosine affects conversion of T4 to T3 and thus increases release of TRH from the pituitary. By this mechanism, Erythrosineinduced rodent thyroid tumours may arise (Jennings et al, 1990). A clinical study with thirty healthy male volunteers evaluated possible effects of sub-chronic administration of three doses of Erythrosine (20, 60 and 200 mg/kg for 14 days) on thyroid function.…”

Highly effective adsorption of xanthene dyes (rhodamine B and erythrosine B) from aqueous solutions onto lemon citrus peel active carbon: characterization, resolving analysis, optimization and mechanistic studies

“…From these sources, EB is introduced into water and thus has undesirable effects on human health. [9][10][11] It has previously been removed from aqueous solutions by adsorption. 9,[12][13][14][15][16] EB in dye mixtures has been analyzed by electrophoresis and derivative spectrophotometry.…”

Effects of a Six-Week Exposure to Excess Iodide on Thyroid Glands of Growing and Nongrowing Male Fischer-344 Rats

“…This atypical hormonal pattern may represent a transient phase between the acute and the chronic phases characterized by increases in both TSH and T4 and thyroid status still under TSH stimulation. Indeed, a similar status can be found in a report on young Sprague-Dawley male rats (250-275 g body weight) exposed to 0.16% sodium iodide (NaI) in their diet for 3 wk that showed increases in serum TSH, T4, and T3 (17). On the other hand, the nongrowing rats treated for 6 wk had already entered the chronic phase (normal TSH and high or normal T4), and the thyroid showed early evidence of colloid accumulation.…”