Effects of oral exposure to silver nanoparticles on the sperm of rats

Lafuente, Daisy; García, Tánia; Blanco, Jordi; Sánchez, Domènec J.; Sirvent, Juan J.; Domingo, José L.; Gómez, Mercedes

doi:10.1016/j.reprotox.2016.02.007

Cited by 58 publications

(43 citation statements)

References 35 publications

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“…The significant (p < 0.05) dosed dependent decreases in the hormonal concentrations of LH, FSH, and testosterone in rats dosed Ag-NP for 7 days and 28 days were consistent with previous studies on the effect of different nanoparticles on hormonal levels of male rats. Lafuente et al [42] reported a significant decrease in the level of testosterone after treatment with ZnO-NP this was; however, reversed by the administration of antioxidants supplement (quercetin). Adebayo et al [43] also reported a decrease in testosterone, FSH, LH, and prolactin after treatment with CeO 2 -NP.…”

Section: Discussionmentioning

confidence: 98%

Silver Nanoparticles Stimulates Spermatogenesis Impairments and Hematological Alterations in Testis and Epididymis of Male Rats

et al. 2020

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The potential pharmaceutical application of nanoparticles has led to the toxicity within the male reproductive system. In the present study, the effects of silver nanoparticles (Ag-NPs) on hematological parameters, free radical generation, antioxidant system, sperm parameters, and organ histo-morphometry in male rats were investigated. Ag-NPs were produced by the reduction of silver ions, while the formation of which was monitored by UV–visible spectrophotometry. Zeta potential, transmission, and scanning electron microscopies were applied for the characterization of AgNPs. A total of 30 rats were divided into 6 groups and were sub-dermally exposed to Ag-NPs at the dosage of 0 (control), 10, and 50 mg/kg bodyweight (bw) doses for either 7 or 28 days. Ag-NP administration altered hematological indices and caused dose-dependent decreases in sperm motility, velocity, kinematic parameters, concentrations of luteinizing hormone, follicle-stimulating hormone, and testosterone. In the epididymis and testis, the concentrations of malondialdehyde and peroxide increases while superoxide dismutase, catalase, reduced glutathione, and total thiol group decreases. These findings suggest that Ag-NP triggered hormonal imbalance and induce oxidative stress in testis and epididymis; which negatively affect sperm parameters of male rats.

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Section: Discussionmentioning

confidence: 98%

Silver Nanoparticles Stimulates Spermatogenesis Impairments and Hematological Alterations in Testis and Epididymis of Male Rats

et al. 2020

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“…However, no difference was observed between different dose groups or sizes. 43,49 Another study showed significant decreases in sperm motility and live percentage and the development of abnormal sperm after treatment with ZnO NPs. In addition, increasing the dose led to greater toxicity.…”

Section: Effect On Germ Cells Effect On Sperm (Potential Reversible Amentioning

confidence: 99%

Potential adverse effects of nanoparticles on the reproductive system

Wang¹,

Song²,

Wu³

et al. 2018

IJN

172

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With the vigorous development of nanometer-sized materials, nanoproducts are becoming widely used in all aspects of life. In medicine, nanoparticles (NPs) can be used as nanoscopic drug carriers and for nanoimaging technologies. Thus, substantial attention has been paid to the potential risks of NPs. Previous studies have shown that numerous types of NPs are able to pass certain biological barriers and exert toxic effects on crucial organs, such as the brain, liver, and kidney. Only recently, attention has been directed toward the reproductive toxicity of nanomaterials. NPs can pass through the blood–testis barrier, placental barrier, and epithelial barrier, which protect reproductive tissues, and then accumulate in reproductive organs. NP accumulation damages organs (testis, epididymis, ovary, and uterus) by destroying Sertoli cells, Leydig cells, and germ cells, causing reproductive organ dysfunction that adversely affects sperm quality, quantity, morphology, and motility or reduces the number of mature oocytes and disrupts primary and secondary follicular development. In addition, NPs can disrupt the levels of secreted hormones, causing changes in sexual behavior. However, the current review primarily examines toxicological phenomena. The molecular mechanisms involved in NP toxicity to the reproductive system are not fully understood, but possible mechanisms include oxidative stress, apoptosis, inflammation, and genotoxicity. Previous studies have shown that NPs can increase inflammation, oxidative stress, and apoptosis and induce ROS, causing damage at the molecular and genetic levels which results in cytotoxicity. This review provides an understanding of the applications and toxicological effects of NPs on the reproductive system.

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“…In fact, some NPs have already demonstrated toxicity to sperm cells. For instance, orally administered silver NPs delayed the onset of puberty, decreased adult sperm production and modified reproductive parameters, with reduced acrosome and plasma membrane integrity [11] and had a slight negative influence on sperm morphology in rats [12]. Furthermore, intravenously-administered silver NPs resulted in lower sperm cell counts together with a higher number of abnormal forms and DNA damage in rats [13].…”

Section: Introductionmentioning

confidence: 99%

In vitro exposure of bull sperm cells to DMSA-coated maghemite nanoparticles does not affect cell functionality or structure

Caldeira

Paulini

Silva

et al. 2017

International Journal of Hyperthermia

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Magnetic nanoparticles can be used in different areas of biology. It is therefore important to know the effects of such nanomaterials on germline cells as they may traverse the blood-testis barrier. This work aimed to evaluate the response of bull sperm after exposure to a magnetic fluid containing DMSA-coated maghemite nanoparticles (MNP-DMSA) in order to determine nanotoxicity. Bull sperm was incubated with MNP-DMSA at final concentrations of 0.06, 0.03 or 0.015 mg Fe/mL. Sperm kinetics, plasma membrane integrity and acrosome reaction were evaluated over a 4 h incubation period. The sperm cells were also evaluated by transmission electron microscopy. Exposure of bull sperm to MNP-DMSA did not affect sperm kinetics or integrity. Neither ultrastructural damage of sperm cells nor uptake of nanoparticles by the spermatozoa was observed. In conclusion, MNP-DMSA does not affect sperm function or structure under the conditions tested.

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Effects of oral exposure to silver nanoparticles on the sperm of rats

Cited by 58 publications

References 35 publications

Silver Nanoparticles Stimulates Spermatogenesis Impairments and Hematological Alterations in Testis and Epididymis of Male Rats

Silver Nanoparticles Stimulates Spermatogenesis Impairments and Hematological Alterations in Testis and Epididymis of Male Rats

Potential adverse effects of nanoparticles on the reproductive system

In vitro exposure of bull sperm cells to DMSA-coated maghemite nanoparticles does not affect cell functionality or structure

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