<i>In vitro</i> exposure of bull sperm cells to DMSA-coated maghemite nanoparticles does not affect cell functionality or structure

Caldeira, Denise Ferreira; Paulini, Fernanda; Silva, Renata Carvalho; Azevedo, Ricardo Bentes; Lucci, Carolina Madeira

doi:10.1080/02656736.2017.1341646

Cited by 16 publications

(6 citation statements)

References 41 publications

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“…The depletion of defective spermatozoa had cascading effect on the overall improvement in the IPM (%) as well with concurrent results from several other authors (Caldeira, Paulini, Silva, Azevedo, & Lucci, 2018; Chung & Son, 2016; Durfey et al., 2017, 2019; Feugang et al., 2015). At the same time, increase in functional integrity (%) of plasma membrane of live spermatozoa might be due to deletion of greater number of nonfunctional spermatozoa by anti‐ubiquitin Abs coated NPs at fresh stage, and consequently reduction in free radicals induced damage to plasma membrane (Kadirvel, Kumar, Ghosh, & Perumal, 2014).…”

Section: Discussionsupporting

confidence: 83%

Nano‐purification of raw semen minimises oxidative stress with improvement in post‐thaw quality of buffalo spermatozoa

et al. 2020

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The dead and damaged spermatozoa present in the fresh ejaculates are carried passively along with the live ones into the processed semen. Such dead and damaged spermatozoa are primarily responsible for the production of reactive oxygen species (ROS). The detrimental effect by way of oxidative stress on the contemporary live spermatozoa results in poor fertility (Roca, Martinez-Alborcia, Gil, Parrilla, & Martinez, 2013). Since the buffalo spermatozoa show high lipid peroxidation (LPO) rate (Nair, Brar, Ahuja, Sangha, & Chaudhary, 2006), comparatively reduced activity of existing antioxidant system (Nair et al., 2006), high content of membrane polyunsaturated fatty acids (Dawra, Sharma, & Makkar, 1983) and increased susceptibility to osmotic stress the damage owing to oxidative stress is exaggerated (Kadirvel, Kumar, & Kumaresan, 2009). The nuclear integrity as well as plasma membrane fluidity is also affected by LPO is another consequence of concern (Roca et al., 2013). In live spermatozoa, production of free radicals is of mitochondrial origin, mostly for the physiological processes. However, the imbalance of free radicals arise either due to excessive production intracellularly under physiological situations

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Section: Discussionsupporting

confidence: 83%

Nano‐purification of raw semen minimises oxidative stress with improvement in post‐thaw quality of buffalo spermatozoa

et al. 2020

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“…Other metal NPs such as dimercaptosuccinic acid (DMSA)-coated maghemite and CeO 2 NPs did not influence ram or bull sperm structure or function when added in vitro [78], [79]. Although CeO 2 NPs were shown to enhance ram semen preservation by chilling [12], it may also have detrimental effects if orally supplemented, since in mice, induction of oxidative stress and lower sperm characteristics were reported [80].…”

Section: Controversies In the Use Of Nanotechnology In Reproduction: mentioning

confidence: 99%

Perspectives of nanotechnology in male fertility and sperm function

Falchi

Khalil

Hassan³

et al. 2018

International Journal of Veterinary Science and Medicine

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Recent advances in nanotechnology have tremendously expanded its possible applications in biomedicine. Although, the effects of nanoparticles (NPs) at cellular and tissue levels have not been fully understood, some of these biological effects might be employed in assisted reproduction to improve male fertility particularly by enhancing sperm cell quality either in vivo or in vitro. This review summarises the available literature regarding the potential applications of nanomaterials in farm animal reproduction, with a specific focus on the male gamete and on different strategies to improve breeding performances, transgenesis and targeted delivery of substances to a sperm cell. Antioxidant, antimicrobial properties and special surface binding ligand functionalization and their applications for sperm processing and cryopreservation have been reviewed. In addition, nanotoxicity and detrimental effects of NPs on sperm cells are also discussed due to the increasing concerns regarding the environmental impact of the expanding use of nanotechnologies on reproduction.

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“…Sperm motility, acrosome integrity, cell membrane, sperm structure, and uptake of nanoparticles were assessed after 4 hours of exposure. No negative effects on motility, viability, and sperm structure were observed and nanoparticles were not able to penetrate the sperm [34].…”

Section: Iron Nanoparticlesmentioning

confidence: 93%

The Effects of Metal Nanoparticles on the Mammalian Reproductive System

Lohrasbi¹,

Bahmanpour²

2021

Nano BioMed ENG

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Due to the increasing use of nanoparticles in medical and industrial fields, concerns are growing about the toxicity of them to the body organs especially the reproductive system. In this review, the effect of metal/metal oxide nanoparticles on the mammalian reproductive system was discussed. Nanoparticles are typically toxic to both males and females, depending on their types, administration method, exposure duration, and surface modification. Regarding the embryo, it was also found that the effect of nanoparticles depends on the embryonic stage exposure during development. However, some nanoparticles, depending on the dose and time of administration, not only did not have toxic effects, but also strengthened the reproductive system and increased its efficiency. As the mode of interaction, penetration, and mechanism of nanoparticles action in the reproductive system is unclear, this review highlights the importance of additional tests in these cases.

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In vitro exposure of bull sperm cells to DMSA-coated maghemite nanoparticles does not affect cell functionality or structure

Cited by 16 publications

References 41 publications

Nano‐purification of raw semen minimises oxidative stress with improvement in post‐thaw quality of buffalo spermatozoa

Nano‐purification of raw semen minimises oxidative stress with improvement in post‐thaw quality of buffalo spermatozoa

Perspectives of nanotechnology in male fertility and sperm function

The Effects of Metal Nanoparticles on the Mammalian Reproductive System

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