Effects of oral hygiene products containing lactoperoxidase, lysozyme, and lactoferrin on the composition of whole saliva and on subjective oral symptoms in patients with xerostomia

Abstract

This study evaluates the effects of two oral hygiene products containing nonimmunoglobulin antimicrobial agents on whole saliva and on subjective oral symptoms in patients with xerostomia. Twenty patients used a lactoperoxidase-system-containing toothpaste (Biotene) combined with the use of a mouthrinse (Biotene), comprising also lysozyme and lactoferrin, for 4 weeks. Saliva samples were collected at base line, after 4 weeks' use of the products, and at the end of a 4-week washout period. Samples were analyzed for selected biochemical and microbiologic factors. The effects on subjective oral symptoms were also recorded. A 4-week daily use of toothpaste and mouthrinse relieved the symptoms of oral dryness in 16 patients. The levels of salivary hypothiocyanite, lysozyme, lactoferrin, or myeloperoxidase activity did not change, but there was a significant decrease in salivary pH (P < 0.05), total peroxidase activity (P < 0.05), and total protein content (P = 0.01). In patients with the lowest salivary flow rates (n = 5) a significant (P > or = 0.04) increase was detected in salivary hypothiocyanite concentrations. No major changes occurred in salivary microflora. The products relieved subjective oral symptoms in most xerostomic patients, but this was not necessarily related to the presence of antimicrobial agents.

Xerostomia Management for Pediatric Oncology Patients with Lactoperoxidase Included Oral Health Care Products

“…No major changes occurred in the level of salivary Thiocyanite and Peroxidase activity ( Figure 1 and Figure 2), but there was an increase in salivary pH and also salivary flow rate was notably higher in each group after using Lactoperoxidase products. Our results demonstrate as in Tenovuo et al [27] study that obviously greater benefit of the incorporation of nonimmunoglobulin agents in oral hygiene products is gained by patients who have severe xerostomia (stimulated flow ≤ 0.2ml/min) than in those who have subjective complaints of dry mouth but the salivary flow rate is notably higher. The long-term efficacy of these products in preventing xerostomia remains to be shown.…”

The effects of sugar-free chewing gums on dental plaque regrowth: A comparative study

“…11 The use of a commercial mouthrinse containing lysozyme, lactoferrin and LP could be useful in xerostomic patients, as suggested by the positive effects observed on subjective oral symptoms in individuals with hyposalivation. 33 A recent 4-day plaque regrowth study, however, showed that such mouthrinse had no plaque inhibitory actions. 34 Similarly, the LP gum we evaluated, although claimed to ''efficaciously reduce plaque'' and ''prevent gingivitis'', provided no plaque control benefits at smooth surfaces.…”

Reduction of Erosion by Protein-Containing Toothpastes

“…For years proteins have been used in oral care products to maintain oral health [Lenander-Lumikari et al, 1993;Kirstila et al, 1996;Pedersen et al, 2002;Tenuvuo, 2002], but the addition of proteins to toothpaste is still controversial. Earlier research on these products showed that it was questionable whether these proteins can be immobilized in the acquired pellicle [Hannig et al, 2005].…”