Effects of Oral Rho Kinase Inhibitor Fasudil on Detrusor Overactivity after Bladder Outlet Obstruction in Rats

Kim, Ji-Yoon; Han, Ji‐Yeon; Kwon, Tae Gyun; Choo, Myung‐Soo

doi:10.1111/j.1757-5672.2012.00169.x

Cited by 6 publications

(1 citation statement)

References 30 publications

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“…BOO causes detrusor smooth muscle (DSM) hypertrophy in the bladder, which leads to impaired bladder storage and voiding ability. After pharmacological or surgical treatment of BOO, OAB symptoms may still persist in 38% of men [1,2].…”

Section: Introductionmentioning

confidence: 99%

The effect of testosterone replacement therapy on bladder functions, histology, apoptosis, and Rho-kinase expression in bladder outlet obstruction and hypogonadism rat model

Saylam¹,

Efesoy²,

Arpacı³

et al. 2021

Turk J Med Sci

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Background/aim The effect of testosterone replacement therapy was investigated on bladder functions, histology, apoptosis as well as Rho-kinase expression in the rat bladder outlet obstruction (BOO) and hypogonadism models. Materials and methods 30 mature male rats divided into 4 groups: sham group (n = 8), BOO group (n = 8), BOO + orchiectomy group (n = 7), BOO + orchiectomy + testosterone (T) treatment group (n = 7). Cystometric findings, apoptosis index, Rho-kinase (ROCK-2) expression, and smooth muscle/collagen ratio were compared. Results BOO did not change ROCK-2 expression level, compared to sham group (P > 0.05). However, when compared to BOO group (P < 0.01), BOO + orchiectomy led ROCK-2 increase. The testosterone treatment failed to reverse the up-regulation of ROCK-2 induced by orchiectomy although it tended to lower ROCK-2 level. Compared to sham group (P = 0.002), changes in maximal bladder capacity and leak point pressure were higher (P = 0.026, P = 0.001), and bladder compliance was lower in BOO group. Also, the apoptosis index was different between the two groups (P = 0.380). Smooth muscle/collagen ratio was higher in BOO + orchiectomy + T group than in BOO + orchiectomy group (P = 0.010). Conclusions The research draws attention to alternating treatment approaches in case of the presence of hypogonadism and BOO.

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Section: Introductionmentioning

confidence: 99%