Effects of oral vitamin D3 supplementation in stage 3 chronic kidney disease subjects: insulin resistance syndrome and hormonal disturb interactions

Tahar, Amina; Zerdoumi, F.; Saïdani, Messaoud; Griene, L.; Koceir, Elhadj Ahmed

doi:10.1684/abc.2018.1342

Cited by 2 publications

(2 citation statements)

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“…In patients without diabetes, even short-term insulin injections will increase urinary protein excretion. On the contrary, the protein in the renal tubule may cause tubulointerstitial damage and brosis [15][16][17][18].…”

Section: Discussionmentioning

confidence: 99%

Association of insulin resistance with chronic kidney disease in individuals without diabetes in a community population in South China

Li,

Zhou,

Liu

et al. 2024

Preprint

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Background: To explore the relationship of insulin resistance (IR) with chronic kidney disease (CKD) in individuals without diabetes. Methods: We performed a cross-sectional survey among 2142 community-based participants without diabetes from southern China from June to October 2012 and excluded the incomplete data. We divided all the participants into four groups according to the quartiles of homeostasis model assessment of IR (HOMA-IR). Logistic regression models were used to explore the associations of IR with CKD in these subjects. Results: In the unadjusted model, compared with the quartile one group, IR was significantly associated with CKD (odds ratio [OR] = 2.24, P < 0.001; OR = 4.46, P < 0.001) in the quartile three and four groups, and the association was still significant (OR = 2.08, P = 0.005; OR = 3.89, P < 0.001 ) after adjusting for potential confounders (including age, current smoker, current alcohol use, physical inactivity, education level, systolic blood pressure, diastolic blood pressure, serum triglyceride, and body mass index). The area under the receiver operating characteristic curve (95% confidence interval) of HOMA-IR for diagnosing CKD was 0.67 (0.64, 0.71). The cut-off value was 2.5, the sensitivity was 75.2%, and the specificity was 56.4%. Conclusions: HOMA-IR is associated with CKD in participants without diabetes. Early intervention for IR is important for reducing the incidence of CKD.

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Section: Discussionmentioning

confidence: 99%

Association of insulin resistance with chronic kidney disease in individuals without diabetes in a community population in South China

Li,

Zhou,

Liu

et al. 2024

Preprint

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show abstract

“…17 Of interest, vitamin D insufficiency shares mutual risk factors with OSA, such as age, obesity, hypertension, kidney diseases and diabetes. 18,19 Nevertheless, among individuals with T2DM, the relationship between vitamin D level and severity of OSA remains unclear.…”

Section: Introductionmentioning

confidence: 99%

<p>The Relationship of Serum 25-Hydroxyvitamin-D Level with Severity of Obstructive Sleep Apnea in Patients with Type 2 Diabetes Mellitus</p>

Zheng²,

Dong

et al. 2020

DMSO

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To explore the association of serum vitamin-D levels with the severity of obstructive sleep apnea (OSA) in patients with type 2 diabetes mellitus (T2DM). Methods: A cross-sectional study of 136 patients with T2DM who underwent overnight polysomnography (PSG) tests and serum 25-hydroxyvitamin-D3 (25(OH)D3) level detections was conducted. Multivariable linear regression and logistic regression analyses were performed to determine the associations of serum 25(OH)D3 levels with apnea-hypopnea index (AHI) and obstructive sleep apnea (OSA).Results: The prevalence rates of OSA were 84.4% for male and 65.2% for female patients, respectively (p = 0.011). With increasing severities of OSA categories (none, mild, moderate and severe), patients were more likely to be male and obese, but there was no significant difference in serum 25(OH)D3 level ((mean ± standard deviation) 21.8 ± 8.8, 27.7 ± 14.6, 24.2 ± 9.8 and 26.8 ± 6.2 ng/mL, respectively, p=0.086). Serum 25(OH)D3 level was not significantly correlated with AHI (log-transformed), with the correlation coefficient of 0.133 (p=0.124). With adjustment for potential confounding factors, multivariable linear regression and logistic regression analyses showed that serum 25(OH)D3 level was not significantly associated with either AHI (log-transformed) or the risk of OSA, with the standardized regression coefficient (95% confidence interval (CI)) of 0.098 (−0.004-0.014, p=0.252) and the adjusted odds ratio (95% CI) of 1.055 (0.991-1.124, p=0.095), respectively. Conclusion: Serum 25(OH)D3 level was not significantly associated with either AHI or the risk of OSA in patients with T2DM.

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Effects of oral vitamin D3 supplementation in stage 3 chronic kidney disease subjects: insulin resistance syndrome and hormonal disturb interactions

Cited by 2 publications

References 0 publications

Association of insulin resistance with chronic kidney disease in individuals without diabetes in a community population in South China

Association of insulin resistance with chronic kidney disease in individuals without diabetes in a community population in South China

<p>The Relationship of Serum 25-Hydroxyvitamin-D Level with Severity of Obstructive Sleep Apnea in Patients with Type 2 Diabetes Mellitus</p>

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