Effects of organic extracts of six Bangladeshi plants on in vitro thrombolysis and cytotoxicity

Rahman, Md. Ferdous; Sultana, Rabeya; Emran, Talha Bin; Islam, Md. Saiful; Chakma, J. S.; Rashid, Harunur; Hasan, Choudhury M.

doi:10.1186/1472-6882-13-25

Cited by 76 publications

(52 citation statements)

References 33 publications

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“…Incubation of all tubes at 37°C for 90 minutes was undertaken for clot lysis. After removing the supernatant, tubes were again weighed to observe clot disruption [12].…”

Section: Thrombolytic Testmentioning

confidence: 99%

Antipyretic, Antidiabetic, Thrombolytic and CNS Depressant Potential of Ethanol Extract of Crotalaria Verrucosa L. Leaves

Nawrin¹,

Billah²,

Jabed³

et al. 2015

Am. J. Biomed. Sci.

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Hyperthermia, hyperglycemia, depression are the most common physiological disorders found in third world countries where people are not well aware of their health condition as well as about their health practice. People in rural and tribal areas depend on the traditional system of medicine where allopathic medicines are not the first choice because of ethnicity and belief. The plant Crotalaria verrucosa is believed as one of the cures in traditional system of medicine for many ailments. The present study was performed to evaluate the antipyretic, antidiabetic, thrombolytic and depressive potential of the leaf extract of this plant. Yeast induced pyrexia, alloxan induced type II hyperglycemia, HRBC clot denaturation, Hole cross and Open field tests were performed to investigate these activities at moderate to high doses (100, 250 and 500 mg/kg). Results of the study suggests that the extract possess strong antipyretic, antidiabetic and CNS depressant activity in higher doses (250 and 500 mg/kg) but lack to exhibit clear thrombolytic potential.

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“…Incubation of all tubes at 37°C for 90 minutes was undertaken for clot lysis. After removing the supernatant, tubes were again weighed to observe clot disruption [12].…”

Section: Thrombolytic Testmentioning

confidence: 99%

Antipyretic, Antidiabetic, Thrombolytic and CNS Depressant Potential of Ethanol Extract of Crotalaria Verrucosa L. Leaves

Nawrin¹,

Billah²,

Jabed³

et al. 2015

Am. J. Biomed. Sci.

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“…12 Extracts and the alkaloids cassine and spectaline of S. spectabilis have no cytotoxic effect on murine macrophages (J774 cell line), 8 and the extract of S. sophera is not cytotoxicity. 13 Barakol, an anxiolytic agent isolated by acid hydrolysis of S. siamea leaves, is toxic to P19 cells and induces apoptosis, 14 but the ethanolic and aqueous extracts of leaves from C. siamea (syn. S. siamea) were not cytotoxic to KB and Vero cells.…”

Section: Introductionmentioning

confidence: 99%

Chemical Profile and Cytotoxic Activity of Leaf Extracts fromSennaspp. from Northeast of Brazil

Silva¹,

Silva²,

Coutinho³

et al. 2016

Journal of the Brazilian Chemical Society

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Methanolic, diethyl ether and n-hexane extracts of leaves of four species of Senna (S. gardneri, S. macranthera, S. splendida and S. trachypus) were analyzed by gas chromatography coupled to mass spectrometry (GC-MS). Using linear retention indices and mass spectral data, 34 compounds were identified, including fatty acids, flavonoids, terpenoids and steroids that were not reported previously for these species. Additionally, the cytotoxicity of the extracts against different tumor cell lines was determined. The cytotoxicity was then correlated with the chemical composition of the extracts by partial least squares-discriminant analysis (PLS-DA). The n-hexane extract of S. gardneri and the ethyl ether extract of S. splendida were the most active against human colon (59.75 and 31.37%, respectively) and human glioblastoma (52.85 and 48.28%, respectively) cell lines.

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“…171 In a similar study conducted by Rahman and coworkers (2013) Clausena suffruticosa, Leea indica, and Leucas aspera were shown to possess effective thrombolytic properties. 172 In 2015, Emran and co-workers showed the potential of Trema orientalis L., Bacopa monnieri L., and Urena sinuate L. in clot lysis using streptokinase as a control. 173 A 34 kDa serine protease, hirtin, purified from the latex of the medicinal herb Euphorbia hirta showed fibrinolytic and fibrinogenolytic activities.…”

Section: Direct Thrombolytic Agentsmentioning

confidence: 99%

The evolution of recombinant thrombolytics: Current status and future directions

Adivitiya

Khasa

2016

Bioengineered

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Cardiovascular disorders are on the rise worldwide due to alcohol abuse, obesity, hypertension, raised blood lipids, diabetes and age-related risks. The use of classical antiplatelet and anticoagulant therapies combined with surgical intervention helped to clear blood clots during the inceptive years. However, the discovery of streptokinase and urokinase ushered the way of using these enzymes as thrombolytic agents to degrade the fibrin network with an issue of systemic hemorrhage. The development of second generation plasminogen activators like anistreplase and tissue plasminogen activator partially controlled this problem. The third generation molecules, majorly t-PA variants, showed desirable properties of improved stability, safety and efficacy with enhanced fibrin specificity. Plasmin variants are produced as direct fibrinolytic agents as a futuristic approach with targeted delivery of these drugs using liposome technlogy. The novel molecules from microbial, plant and animal origin present the future of direct thrombolytics due to their safety and ease of administration.

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Effects of organic extracts of six Bangladeshi plants on in vitro thrombolysis and cytotoxicity

Cited by 76 publications

References 33 publications

Antipyretic, Antidiabetic, Thrombolytic and CNS Depressant Potential of Ethanol Extract of Crotalaria Verrucosa L. Leaves

Antipyretic, Antidiabetic, Thrombolytic and CNS Depressant Potential of Ethanol Extract of Crotalaria Verrucosa L. Leaves

Chemical Profile and Cytotoxic Activity of Leaf Extracts fromSennaspp. from Northeast of Brazil

The evolution of recombinant thrombolytics: Current status and future directions

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