Effects of organosulfur compounds from garlic oil on the antioxidation system in rat liver and red blood cells

Wu, Chih-Chung; Sheen, Lee‐Yan; Chen, H.-W; Tsai, Suh‐Jen Jane; Lii, Chong‐Kuei

doi:10.1016/s0278-6915(00)00171-x

Cited by 179 publications

(91 citation statements)

References 37 publications

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“…Also, it exerts its effect by enhancing the nonenzymatic antioxidant (GSH) and the detoxifying enzyme (glutathione S-transferase) (Saravanan & Prakash, 2004). Allicin may provide the sulfur source required for the synthesis of GSH (Wu et al, 2001). Treatment with allicin could reduce the electrophilic burden and thereby increase GSH levels in lung.…”

Section: Discussionmentioning

confidence: 99%

Modulation of cyclophosphamide-induced early lung injury by allicin

Ashry

Gameil

Suddеk

2013

Pharmaceutical Biology

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Context: Cyclophosphamide (CP) causes lung injury in rats through its ability to generate free radicals with subsequent epithelial and endothelial cell damage. Objective: This study was conducted to assess whether allicin can ameliorate CP-induced early lung injury in rats. Materials and methods: Male Sprague Dawely rats were divided into four groups. Group I was the control group. Group II received allicin (50 mg/kg/d, p.o.) for 14 consecutive days. Group III was injected once with CP (150 mg/kg, i.p.). Group IV received allicin for seven consecutive days, before and after CP injection (150 mg/kg, i.p.). The parameters of study were serum biomarkers, lung tissue antioxidant profile and histopathological changes in lung tissue. Results: A single intraperitoneal injection of CP markedly altered the levels of several biomarkers in lung homogenates. Significant increases in lung content of lipid hydroperoxides were seen that paralleled the decreased levels of total reduced glutathione. Superoxide dismutase activity (SOD) was significantly increased. CP increased the level of serum biomarkers; total protein, lactate dehydrogenase (LDH) and tumor necrosis factor-alpha (TNF-a). Pretreatment of rats daily with oral allicin seven days prior to and seven days after CP inject significantly inhibited the development of lung injury, prevented the alterations in lung and serum biomarkers associated with inflammatory reactions, with less lipid peroxidation (LP) and restoration of antioxidants. Moreover, allicin attenuated the secretion of proinflammatory cytokine, TNF-a expression in rat serum. In addition, allicin effectively blunted CP-induced histopathological changes in lung tissue. Discussion and conclusion: Our results suggest that allicin is efficient in blunting CP-induced pulmonary damage.

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Section: Discussionmentioning

confidence: 99%

Modulation of cyclophosphamide-induced early lung injury by allicin

Ashry

Gameil

Suddеk

2013

Pharmaceutical Biology

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“…Indeed, Welsh onion possesses antioxidant compounds such as quercetin and kaempferol as main phenol compounds (Wang et al, 2006), ascorbic acid (Kähkönen and Heinonen, 2003), and volatile sulfur compounds (Wu et al, 2001). Thus, it is possible that the content of other antioxidant compounds besides phenol compounds may be increased in the…”

Section: Resultsmentioning

confidence: 99%

Changes in Sugar Content and Antioxidant Activity of Allium Vegetables by Salinity-stress

Arakaki

Takahashi

Hossain

et al. 2014

FSTR

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Three Allium vegetables, Welsh onion from Okinawa, and Wakegi from Okinawa and Nagasaki were subjected to salinity-stress using seawater. The K + /Na + ratio of the three Allium vegetables clearly decreased; however, there was no significant effect on growth parameters. Of the three Allium vegetables, 10% seawater treatment of Welsh onion and Wakegi from Nagasaki clearly enhanced both the sugar content and antioxidant activity. Therefore, seawater treatment may be potentially useful for the development of value-added Allium vegetables, enhancing the palatability and food functionality.Keywords: Allium vegetable, salinity-stress, seawater, sugar content, antioxidant activity IntroductionSalinity is a major environmental factor limiting crop growth and productivity (Rhodales and Loveday, 1990). During the onset and development of salinity-stress within a crop plant, major processes such as photosynthesis, protein synthesis, and energy and lipid metabolism are affected, leading to qualitative and yield losses in most crops (Hasegawa et al., 2000; Hagemann and Erdmann, 1997; Hayashi and Murata 1998). However, there are several crops with an inherent capacity to withstand salinity-stress, which allows for stable vegetable production and significantly contributes to palatability and food functionality (Sato et al., 2006). Thus, there have been several reports on the application of salinity-stress for improving the quality of vegetables such as tomato fruits (Auerswald et al., 1999), spinach (Makabe and Tanii, 2008), and strawberry (Keutgen and Pawelzik, 2000).Welsh onion (Allium fistulosum L.), a member of the Allium family, is a popular vegetable in Asian countries and a reputed good source of phenol compounds with antioxidant activity, leading to beneficial medicinal effects (Helen et al., 2000;Wang et al., 2006).Hence, we focused our attention on exploiting salinity-stress treatment for the development of value-added Welsh onion with augmented palatability and food functionality. There are relatively few studies on the salt tolerance of Welsh onion. In this study, we investigate the effects of artificial salinity-stress on the growth, relative chlorophyll content, and K + /Na + ratio of Allium vegetables: Welsh onion and Wakegi (Allium x wakegi A.), and assess the effect of salinity-stress on sugar content, total phenol content, and antioxidant activity. Materials and MethodsCultivation The bulbs of three types of Japanese Allium cultivars, green-leafy Welsh onion (Okinawa) and two different cultivation lines of Wakegi from Okinawa and Nagasaki (NagasakiWakegi) were used in this study. The upper end of each bulb was cut to adjust the overall length to 5 cm before cultivation. Each bulb type was randomly divided into four test groups of 15 plants each. One group was treated with distilled water (control), and the other three groups were treated with different concentrations of seawater (2% seawater: SW 1; 10% seawater; SW 2; 100% seawater: SW 3) to induce salinity-stress. Each type of bulb was cultivated in a W...

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“…However, DADS does not significantly influence the activities of TST in tumorbearing mice (Iciek et al 2005). Recently, we have found Hu et al (1996); 14 Dragnev et al (1995); 15 Sheen et al (1999); 16 Dwivedi et al(1996); 17 Guyonnet et al (1999); 18 Andorfer et al (2004); 19 Demeule et al (2004); 20 Iciek et al (2005); 21 Wu et al (2001); 22 Hatono et al (1996); 23 Sumiyoshi and Wargovich (1990); 24 Sabelli et al 2008 that garlic-derived 2-PTS is able to interact with the active site of the rhodanese enzyme inducing thiolation of the catalytic cysteine, forming a characteristic disulfide bond which is not cleavable by a nucleophilic attack of cyanide (Sabelli et al 2008). A significant reduction of TST activity has been observed during 2-PTS treatments indicating that cyanide detoxification of rhodanese is reduced by the presence of 2-PTS.…”

Section: Oscs In the Cyanide Detoxificationmentioning

confidence: 91%

Allyl sulfur compounds and cellular detoxification system: effects and perspectives in cancer therapy

2010

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Natural organosulfur compounds (OSCs) have been shown to have chemopreventive effects and to suppress the proliferation of tumor cells in vitro through the induction of apoptosis. The biochemical mechanisms underlying the antitumorigenic and anti-proliferative effects of garlic-derived OSCs are not fully understood. Several modes of action of these compounds have been proposed, and it seems likely that the rate of clearance of allyl sulfur groups from cells is a determinant of the overall response. The aim of this review is to focus attention on the effects of natural allyl sulfur compounds on the cell detoxification system in normal and tumor cells. It has been already reported that several natural allyl sulfur compounds induce chemopreventive effects by affecting xenobiotic metabolizing enzymes and inducing their down-activation. Moreover, different effects of water-and oil-soluble allyl sulfur compounds on enzymes involved in the detoxification system of rat tissues have been observed. A direct interaction of the garlic allyl sulfur compounds with proteins involved in the detoxification system was studied in order to support the hypothesis that proteins possessing reactive thiol groups and that are involved in the detoxification system and in the cellular redox homeostasis, are likely the preferential targets of these compounds. The biochemical transformation of the OSCs in the cell and their adducts with thiol functional groups of these proteins, could be considered relevant events to uncover the anticancer properties of the allyl sulfur compounds. Although additional studies, using proteomic approaches and transgenic models, are needed to identify the molecular targets and modes of action of these natural compounds, the allyl sulfur compounds can represent potential ideal agents in anticancer therapy, either alone or in association with other antitumor drugs.

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Effects of organosulfur compounds from garlic oil on the antioxidation system in rat liver and red blood cells

Cited by 179 publications

References 37 publications

Modulation of cyclophosphamide-induced early lung injury by allicin

Modulation of cyclophosphamide-induced early lung injury by allicin

Changes in Sugar Content and Antioxidant Activity of Allium Vegetables by Salinity-stress

Allyl sulfur compounds and cellular detoxification system: effects and perspectives in cancer therapy

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