2017
DOI: 10.1212/wnl.0000000000003452
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Effects of orthostatic hypotension on cognition in Parkinson disease

Abstract: Objective: To investigate the relation between orthostatic hypotension (OH) and posturemediated cognitive impairment in Parkinson disease (PD) using a cross-sectional and withingroup design.Methods: Individuals without dementia with idiopathic PD included 18 with OH (PDOH) and 19 without OH; 18 control participants were also included. Neuropsychological tests were conducted in supine and upright-tilted positions. Blood pressure was assessed in each posture. Results:The PD groups performed similarly while supin… Show more

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Cited by 97 publications
(65 citation statements)
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“…Studies in PD suggested that OH is associated with cognitive impairment [64][65][66][67] and may underlie a posturemediated exacerbation. 68,69 To our knowledge, only few studies have addressed this issue in MSA with controversial findings. 16,46,51,70 In this study, we could not identify any difference in cognition in MSA patients with and without OH, and we did not find any correlation between cognitive impairment and cardiovascular dysfunction.…”
Section: Discussionmentioning
confidence: 99%
“…Studies in PD suggested that OH is associated with cognitive impairment [64][65][66][67] and may underlie a posturemediated exacerbation. 68,69 To our knowledge, only few studies have addressed this issue in MSA with controversial findings. 16,46,51,70 In this study, we could not identify any difference in cognition in MSA patients with and without OH, and we did not find any correlation between cognitive impairment and cardiovascular dysfunction.…”
Section: Discussionmentioning
confidence: 99%
“…Prior studies have linked the presence of hallucinations to greater cognitive impairment, with some studies demonstrating greater executive dysfunction in hallucinators, and other studies implicating attentional dysfunction in the pathophysiology of hallucinations in PD . Orthostatic hypotension, and the associated symptom of lightheadedness, has been associated with cognitive impairment in PD, possibly as a result of cerebral hypoperfusion or through peripheral noradrenergic dysfunction . Apathy has been associated with cognitive impairment, particularly with executive dysfunction, in patients with PD .…”
Section: Discussionmentioning
confidence: 99%
“…It has been well described that some patients may manifest with fatigue, trouble concentrating, or even cognitive impairment that is truly orthostatic in nature. An effort to understand the role of decreased cerebral perfusion as a result of nOH and it's relationship to cognitive function in PD patients was recently published in Neurology [1]. The authors recruited patients with PD, either without or with known orthostatic hypotension (PDOH), and controls without PD.…”
Section: Let's Sit Down and Think About Thismentioning
confidence: 99%