Effects of Osteochondrin S and select connective tissue ribonucleinate components on human osteoclasts in vitro

Abstract

Osteochondrin S inhibited the resorptive ability of osteoclasts. These actions are likely to occur at a late stage during osteoclast formation, downstream of NFATc1. Overall, the findings show that Osteochondrin S inhibition of osteoclast activity may be responsible for its beneficial effects on diseases such as osteoarthritis.

Osteoprotective Properties of RNA-Containing Drug Osteochondrin S on the Model of Insufficiency of Sex Hormones in Rats

“…This biologically active substance, known as the ribonucleic acid extract, the derivative of the connective tissue of animals and yeast (Schroeder et al; Rainsford). Osteochondrin S is a unique natural product that, due to its therapeutic effect obtained under empirical, long-term use by physicians in patients with osteoarthritis, attracted the attention of researchers who found this biological product was able to inhibit the activity of osteoclasts (Cantley et al, 2013). Early experimental work Republican State Enterprise "National Center for Biotechnology" under the Science Committee of Ministry of Education and Science of the Republic of Kazakhstan.…”