Effects of ovarian puncture for in vitro maturation on subsequent in vitro fertilization cycle in women with polycystic ovaries

Agdi, Mohammed; Zarei, Afsoon; Al-Sannan, Baydaa; Tulandi, Togas; Tan, Seang Lin

doi:10.1016/j.fertnstert.2009.09.033

Cited by 10 publications

(10 citation statements)

References 12 publications

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“…Whether ovarian puncture for IVM treatment could enhance clinical outcomes of subsequent conventional ART treatment in patients with PCOS, remains to be confirmed. The short-term improvement of endocrine parameters related to excess follicle number and increased androgen biosynthesis in patients with PCOS might result in an increased number of oocytes and embryos in IVF cycles following IVM as observed by Agdi et al [6]. However, the data from our study do not confirm this hypothesis.…”

Section: Discussioncontrasting

confidence: 78%

“…Using a similar approach, Ferraretti et al performed transvaginal ovarian puncture in PCOS patients to improve IVF results and named this procedure “transvaginal ovarian drilling” [29]. In a case-control study in 42 patients with PCOS who had IVM treatment before conventional IVF and 48 patients with PCOS who had not had IVM before, significantly more oocytes and embryos in subsequent IVF cycles were obtained in patients who had had IVM treatment [6]. Moreover, Frantz et al reported three spontaneous pregnancies in women with PCOS after transvaginal ovarian punctures for IVM.…”

Section: Discussionmentioning

confidence: 99%

“…During an IVM cycle, egg collection is typically performed using multiple transvaginal punctures of unstimulated or minimally stimulated ovaries; a recent retrospective study suggested that this egg collection procedure may exhibit a similar effect to that of laparoscopic ovarian drilling (LOD) [6]. According to this trial, oocyte retrieval for IVM was associated with an increased number of mature oocytes and embryos in subsequent in vitro fertilisation (IVF) cycles, implying that these punctures may have improved the endocrinological profile of patients with polycystic ovaries.…”

Section: Introductionmentioning

confidence: 99%

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The effect of ovarian puncture on the endocrine profile of PCOS patients who undergo IVM

Ortega-Hrepich¹,

Polyzos²,

Anckaert³

et al. 2014

Reprod Biol Endocrinol

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BackgroundTo examine whether ovarian puncture for immature oocyte retrieval and in-vitro maturation (IVM) has an effect on the endocrine profile of patients with polycystic ovary syndrome (PCOS).MethodsTwenty-two consecutive patients with PCOS undergoing IVM treatment were included. Serum anti-Müllerian hormone (AMH), sex hormone-binding globulin (SHBG), total testosterone (TT) and luteinized hormone (LH) levels were analyzed at the start of the cycle, on the day of immature oocyte retrieval (OR) and at fixed intervals thereafter, for up to three months after OR.ResultsFive days after OR circulating AMH, TT, calculated free testosterone (FTc), and LH levels were significantly reduced and circulating SHBG was significantly increased. Two weeks after OR, TT, FTc and LH remained reduced, whereas circulating AMH and SHBG levels recovered to pre-puncture values. Three months after OR, all circulating hormone levels had recovered to baseline values.ConclusionOvarian puncture for the retrieval of immature oocytes and IVM in patients with PCOS has a significant impact on the ovarian endocrine profile, but this impact is brief and transient.

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Section: Discussioncontrasting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The effect of ovarian puncture on the endocrine profile of PCOS patients who undergo IVM

Ortega-Hrepich¹,

Polyzos²,

Anckaert³

et al. 2014

Reprod Biol Endocrinol

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“…They reported previous ovarian puncture for IVM to be associated with a higher number of mature oocytes and embryos, but not to be associated with a better pregnancy rate. However, they did not assess AMH measurements in these patients [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

The impact of repetitive oocyte retrieval on the ovarian reserve: a retrospective cohort study

Marschalek

Ott

Aitzetmueller

et al. 2019

Arch Gynecol Obstet

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Purpose To investigate a possible influence of repetitive micro-traumata on the ovaries in the course of oocyte retrieval during IVF/ICSI treatment on serum anti-Müllerian hormone (AMH) levels. Methods The study included retrospectively collected data from women who underwent three or more consecutive IVF/ICSI treatments between 2007 and 2017. The primary endpoint of the study was to evaluate changes in serum AMH levels on cycle days 1–3 during the course of repetitive IVF/ICSI treatments. Results A total of 125 patients were included in this study. Median AMH levels before the first, second and third IVF/ICSI cycles were 3.8 ng/mL (IQR 1.8–7.1), 3.3 ng/mL (IQR 1.8–6.1) and 3.0 ng/mL (IQR 1.6–5.3), respectively ( p = n.s.). In patients who underwent IVF/ICSI due to polycystic ovary syndrome (PCOS), we found a significant decrease in AMH serum levels between the first [AMH 9.7 ng/mL (IQR 7.4–14.4)] and the third [AMH 5.3 ng/mL (IQR 3.3–10.4)] IVF/ICSI cycles ( p = 0.026). When performing a generalized linear model, we found PCOS to be an independent predictor for serum AMH decrease during the course of three oocyte retrievals ( p < 0.001). Conclusions When comparing the indications for IVF/ICSI, we observed a significant decrease in AMH serum levels after repetitive oocyte retrievals only in women with PCOS, while the decrease in AMH was not significant in patients with tubal factor, endometriosis, male factor and unexplained infertility. This finding leads us to hypothesize that repetitive micro-traumata on the ovarian cortex might diminish/normalize functional ovarian reserve in women with PCOS. Further prospective studies are highly warranted to allow firm conclusions.

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“…If IVM treatment does not result in pregnancy, subsequent IVF protocols should be arranged as soon as possible. Agdi et al [10] reported that previous puncture for IVM was associated with an increase in the number of mature oocytes retrieved and the total number of embryos produced in subsequent IVF cycles, although there were no significant differences in the clinical pregnancy rate or the occurrence of moderate and severe OHSS [10]. Ferraretti et al [11] reported that transvaginal ovarian drilling improved IVF results in difficult-to-treat patients with PCOS, with the IVF cycle after transvaginal ovarian drilling resulting in significantly higher fertilization and embryo cleavage rates [11].…”

Section: Introductionmentioning

confidence: 99%

Outcomes of in vitro fertilization cycles among patients with polycystic ovary syndrome following ovarian puncture for in vitro maturation

Lin

Wang

Zhao

et al. 2016

Intl J Gynecology & Obste

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Effects of ovarian puncture for in vitro maturation on subsequent in vitro fertilization cycle in women with polycystic ovaries

Cited by 10 publications

References 12 publications

The effect of ovarian puncture on the endocrine profile of PCOS patients who undergo IVM

The effect of ovarian puncture on the endocrine profile of PCOS patients who undergo IVM

The impact of repetitive oocyte retrieval on the ovarian reserve: a retrospective cohort study

Outcomes of in vitro fertilization cycles among patients with polycystic ovary syndrome following ovarian puncture for in vitro maturation

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