Effects of oxiracetam-nicotine combinations on active and passive avoidance learning in mice

Sansone, Mario; Castellano, Claudio; Battaglia, Mario Alberto; Ammassari–Teule, Martine

doi:10.1016/0091-3057(91)90421-w

Cited by 31 publications

(10 citation statements)

References 16 publications

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“…Pair-wise comparisons revealed that the group that had been treated with 0.4 mg/kg had a significantly higher retention score than each of the other groups (p<0.05 for each comparison), while no differences were found among the other groups (Fig. 3B) consistent with previous works [16].…”

Section: Resultssupporting

confidence: 91%

“…Nicotine has effects on mnemonic functions; for example, nicotine improves long-term spatial memory, as measured in the Morris Water Maze [13], [14] and procedural learning, evaluated in the one-trial step-through inhibitory-avoidance task [15], [16]. Administration of nicotine also enhances cognitive functions in pathological conditions such as Alzheimer’s disease [13], [17], [18], and it reverses memory deficits caused by a lesion of the cholinergic system [19], [20], [21], [22].…”

Section: Introductionmentioning

confidence: 99%

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Nicotine Uses Neuron-Glia Communication to Enhance Hippocampal Synaptic Transmission and Long-term Memory

et al. 2012

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Nicotine enhances synaptic transmission and facilitates long-term memory. Now it is known that bi-directional glia-neuron interactions play important roles in the physiology of the brain. However, the involvement of glial cells in the effects of nicotine has not been considered until now. In particular, the gliotransmitter D-serine, an endogenous co-agonist of NMDA receptors, enables different types of synaptic plasticity and memory in the hippocampus. Here, we report that hippocampal long-term synaptic plasticity induced by nicotine was annulled by an enzyme that degrades endogenous D-serine, or by an NMDA receptor antagonist that acts at the D-serine binding site. Accordingly, both effects of nicotine: the enhancement of synaptic transmission and facilitation of long-term memory were eliminated by impairing glial cells with fluoroacetate, and were restored with exogenous D-serine. Together, these results show that glial D-serine is essential for the long-term effects of nicotine on synaptic plasticity and memory, and they highlight the roles of glial cells as key participants in brain functions.

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Section: Resultssupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Nicotine Uses Neuron-Glia Communication to Enhance Hippocampal Synaptic Transmission and Long-term Memory

et al. 2012

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“…In Section 2, we describe the performance of 12 rats trained on an auditory-cognitive task, i.e., auditory-cued active avoidance. Performance on this task is impaired by lesions of auditory cortex (Delay and Rudolph, 1994; Duvel et al, 2001; Ohl et al, 1999), and enhanced by systemic administration of nicotine (Erickson, 1971; Sansone et al, 1994a; Sansone et al, 1994b; Sansone et al, 1991; Yilmaz et al, 1997). Finally, in Section 3, we present 18 F-nifene binding data for six rats—the three best-performing and three worst-performing animals from the cohort in Section 2—in order to correlate performance with binding in selected brain regions.…”

Section: Resultsmentioning

confidence: 99%

Nicotinic acetylcholine receptors in rat forebrain that bind ¹⁸F‐nifene: Relating PET imaging, autoradiography, and behavior

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Kant

Constantinescu

et al. 2012

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Nicotinic acetylcholine receptors (nAChRs) in the brain are important for cognitive function; however, their specific role in relevant brain regions remains unclear. In this study we used the novel compound 18F-nifene to examine the distribution of nAChRs in the rat forebrain, and for individual animals related the results to behavioral performance on an auditory-cognitive task. We first show negligible binding of 18F-nifene in mice lacking the β2 nAChR subunit, consistent with previous findings that 18F-nifene binds to α4β2* nAChRs. We then examined the distribution of 18F-nifene in rat using three methods: in vivo PET, ex vivo PET and autoradiography. Generally, 18F-nifene labeled forebrain regions known to contain nAChRs, and the three methods produced similar relative binding among regions. Importantly, 18F-nifene also labeled some white matter (myelinated axon) tracts, most prominently in the temporal subcortical region that contains the auditory thalamocortical pathway. Finally, we related 18F-nifene binding in several forebrain regions to each animal’s performance on an auditory-cued, active avoidance task. The strongest correlations with performance after 14 days training were found for 18F-nifene binding in the temporal subcortical white matter, subiculum and medial frontal cortex (correlation coefficients, r > 0.8); there was no correlation with binding in the auditory thalamus or auditory cortex. These findings suggest that individual performance is linked to nicotinic functions in specific brain regions, and further support a role for nAChRs in sensory-cognitive function.

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“…A variety of animal studies have shown that nicotine improves learning and memory performance (B/ittig 1970;Bovet-Nitti 1966;Buccafusco and Jackson 1991 ;Clarke 1987;Elrod et al 1988;Erickson 1971;Evangelista and Izquirierdo 1972;Garg and Holland 1969;Haroutunian etal. 1985;Levin et al 1990aLevin et al , 1992aRose 1990, 1991;Nelsen 1978;Nordberg and Bergh 1985;Oliverio 1966Oliverio , 1968Orsingher and Fulginiti 1971 ;Pradhan 1970;Sansone et al 1991;Sasaki et al t991). However, some studies have not detected effects or have documented negative actions (Essman and Essman 1971 ;Hunter et al 1977;Dunnett and Martel 1990;Bammer 1982;Mundy and Iwamoto 1988 a, b;Welzl et al 1988).…”

Section: Nicotine Effects In Experimental Animalsmentioning

confidence: 99%

“…More recent studies have found that acute pre-trial nicotine found that acute nicotine administration (0.125 mg/kg) improves passive avoidance learning (Sansone et al 1991 ;Sasaki et al 1991) and retention (Nordberg and Bergh 1985). Nicotine also improves passive avoidance learning (Sansone et al 1991). Dose of nicotine can be critically important.…”

Section: Nicotine Effects In Experimental Animalsmentioning

confidence: 99%

Nicotinic systems and cognitive function

1992

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Nicotinic acetylcholine receptors have been found to be important for maintaining optimal performance on a variety of cognitive tasks. In humans, nicotine-induced improvement of rapid information processing is particularly well documented. In experimental animals nicotine has been found to improve learning and memory on a variety of tasks, while the nicotinic antagonist mecamylamine has been found to impair memory performance. Nicotine has been found to be effective in attenuating memory deficits resulting from lesions of the septohippocampal pathway or aging in experimental animals. Nicotinic receptors are decreased in the cortex of patients with Alzheimer's disease. Preliminary studies have found that some aspects of the cognitive deficit in Alzheimer's disease can be attenuated by nicotine. Nicotine may prove to be useful therapeutic treatment for this and other types of dementia.

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Effects of oxiracetam-nicotine combinations on active and passive avoidance learning in mice

Cited by 31 publications

References 16 publications

Nicotine Uses Neuron-Glia Communication to Enhance Hippocampal Synaptic Transmission and Long-term Memory

Nicotine Uses Neuron-Glia Communication to Enhance Hippocampal Synaptic Transmission and Long-term Memory

Nicotinic acetylcholine receptors in rat forebrain that bind ¹⁸F‐nifene: Relating PET imaging, autoradiography, and behavior

Nicotinic systems and cognitive function

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Effects of oxiracetam-nicotine combinations on active and passive avoidance learning in mice

Cited by 31 publications

References 16 publications

Nicotine Uses Neuron-Glia Communication to Enhance Hippocampal Synaptic Transmission and Long-term Memory

Nicotine Uses Neuron-Glia Communication to Enhance Hippocampal Synaptic Transmission and Long-term Memory

Nicotinic acetylcholine receptors in rat forebrain that bind 18F‐nifene: Relating PET imaging, autoradiography, and behavior

Nicotinic systems and cognitive function

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Nicotinic acetylcholine receptors in rat forebrain that bind ¹⁸F‐nifene: Relating PET imaging, autoradiography, and behavior