Effects of Pachyman in Combination with Vinorelbine and Cisplatin on Tumor Growth and the Expression of EGFR and K-ras in Mice with Lung Cancer

Wei, Ke; Zhou, Jiahao; Chen, Yongchao; Tian, Jiaming; Sun, M.; Dai, Xin-Wen; Li, Bai-Hui; Li, Ling; Zhou, Fangliang; Ning, Yi; Hu, Jue; Qin, Xiang; Zhang, Bo; Lü, Fang

doi:10.1016/s2589-3777(19)30056-4

Cited by 2 publications

(1 citation statement)

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“…On the other hand, gut translocation of BG from intestinal fungi enhances systemic inflammation, indicating a diverse influence of BG in specific conditions [ 11 , 34 , 40 ]. With the proinflammatory property, Pachyman transforms the anti-inflammatory state around the cancer tissue into proinflammatory conditions that attenuate malignancy [ 91 , 92 ], and WGP incubation induces proinflammatory macrophages [ 93 ]. In contrast, Oat-BG exhibits an anti-inflammatory effect in some situations (Crohn’s disease, obesity, and vigorous exercise) [ 18 , 19 , 94 , 95 ].…”

Section: Discussionmentioning

confidence: 99%

More Prominent Inflammatory Response to Pachyman than to Whole-Glucan Particle and Oat-β-Glucans in Dextran Sulfate-Induced Mucositis Mice and Mouse Injection through Proinflammatory Macrophages

Hiengrach

Visitchanakun

Finkelman

et al. 2022

IJMS

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(1→3)-β-D-glucans (BG) (the glucose polymers) are recognized as pathogen motifs, and different forms of BGs are reported to have various effects. Here, different BGs, including Pachyman (BG with very few (1→6)-linkages), whole-glucan particles (BG with many (1→6)-glycosidic bonds), and Oat-BG (BG with (1→4)-linkages), were tested. In comparison with dextran sulfate solution (DSS) alone in mice, DSS with each of these BGs did not alter the weight loss, stool consistency, colon injury (histology and cytokines), endotoxemia, serum BG, and fecal microbiome but Pachyman–DSS-treated mice demonstrated the highest serum cytokine elicitation (TNF-α and IL-6). Likewise, a tail vein injection of Pachyman together with intraperitoneal lipopolysaccharide (LPS) induced the highest levels of these cytokines at 3 h post-injection than LPS alone or LPS with other BGs. With bone marrow-derived macrophages, BG induced only TNF-α (most prominent with Pachyman), while LPS with BG additively increased several cytokines (TNF-α, IL-6, and IL-10); inflammatory genes (iNOS, IL-1β, Syk, and NF-κB); and cell energy alterations (extracellular flux analysis). In conclusion, Pachyman induced the highest LPS proinflammatory synergistic effect on macrophages, followed by WGP, possibly through Syk-associated interactions between the Dectin-1 and TLR-4 signal transduction pathways. Selection of the proper form of BGs for specific clinical conditions might be beneficial.

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