Effects of Panax ginseng on the nerve growth factor expression in testosterone induced benign prostatic hyperplasia

Abstract

The prostatic hyperplasia in benign prostatic hyperplasia (BPH) leads to obstructive micturition symptoms. Previous studies showed that pontine micturition center (PMC), ventrolateral periaqueductal gray (vlPAG), and medial preopticnucleus (MPA) regions in the brain have been known to regulate the urinary bladder function. The present study shows the influences of on nerve growth factor (NGF) expressions in PMC, vlPAG, and MPA regions in the brain. Wistar rats were used for the present study. The rats split into four groups; 4 groups ( = 6) in control group, BPH-induced group, BPH-induced and treated group, and BPH-induced and finasteride-treated group. BPH in rats was induced by testosterone and the animals were evaluated for NGF expression in PMC, vlPAG, and MPA regions in the brain. The NGF expression was identified using immunohistochemistry (IHC). The NGF expression by IHC showed spots with dark brown color. In our results, NGF expressions in PMC, vlPAG, and MPA regions in the brainstem of the BPH-induced group showed increase than the control animal. These increased NGF expressions in three regions were decreased using treatment with (200 mg/kg). These results suggest that has therapeutic effects on the symptoms of BPH and is associated with the regulation of NGF expression in the brain. In conclusion, the administration of helps nerve growth factor activation.

Clinical Outcome of Pretreatment with Mifepristone before Laparoscopic Myomectomy

“…Also, the average diameter of hysteromyoma in the research group was 5.6±2.0 cm before mifepristone pretreatment, while the average diameter of the hysteromyoma after mifepristone pretreatment was 3.0±1.0 cm. These results agree with recent findings [9][10][11][12][13] . To sum up, laparoscopic myomectomy has been widely used in clinical surgery, but the risk of blood loss during surgery would be increased if the hysteromyoma was large, thus increasing the difficulty Fig.…”

Phytoadaptogens in the Tumours Biotherapy and Geriatrics (Part 1)

“…Экстракт женьшеня у крыс самцов увеличивал объем спермы в тестикулах и придатках без изменения их массы и морфологии [47]. При возрастании уровня тестостерона и лютеинизированного гормона в крови отмечали восстановление нарушенного сексуального поведения и усиление копуляторной активности крыс [48]. Такой эффект, возможно, частично зависит от прямого воздействия гинзенозидов на выработку гормонов передней доли гипофиза, поскольку добавление биологически активных веществ женьшеня in vitro к клеточным элементам мозговой железы сопровождалось усилением процессов секреции [49].…”