Effects of Papaver rhoeas extract on the acquisition and expression of morphine-induced conditioned place preference in mice

Sahraei, Hedayat; Fatemi, Sayedeh Maedeh; Pashaeirad, S H; Faghih-Monzavi, Zohreh; Salimi, Seyed Hossein; Kamalinegad, Mohammad

doi:10.1016/j.jep.2005.08.022

Cited by 40 publications

(38 citation statements)

References 15 publications

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“…An infusion is taken internally in the treatment of bronchial complaints and coughs, insomnia, poor digestion, nervous digestive disorders and minor painful conditions. The flowers are also used in the treatment of jaundice and -in very small quantities-as a sleep-inducing drug [9,10].Papaver rhoeas plant extract contains a lot of flavonoids: kaempferol, quercetin, luteolin and hypolaetin andAntioxidant activity of the kaempferol [12][13], quercetin [14][15] and luteolin [16] was already demonstrated. Total phenolic compounds (9.73 -19.91 mg GAE/g) and total flavonoids (7.904-11.45 mg QE/g) were determined in fresh petals [17].…”

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confidence: 99%

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Biological activity of plant extract isolated from Papaver rhoeas on human lymfoblastoid cell line

Hašplová¹,

Hudecová²,

Miadoková³

et al. 2011

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Varied medicinal plants are known as a source of natural phytochemicals with antioxidant activities that can protect organisms from oxidative stress and from various chronic diseases. Papaver rhoeas has a long history of medicinal usage, especially for ailments in adults and children. The possible cytotoxicity, genotoxicity and potential antioxidant effect of plant extract isolated from flowers of Papaver rhoeas was investigated in human lymfoblastoid cell line (TK6). Antioxidant activity of this extract was determined using the DPPH assay. The plant extract exhibited dose dependent free radical scavenging ability. The growth activity assay was used for determination of cytotoxicity. To assess potential genotoxicity the comet assay was used. The lower extract concentrations (0.25 and 0.5 mg/ml) neither exerted cytotoxic, nor genotoxic effects in TK6 cells but they stimulated cell proliferation. The concentration 25 mg/ml scavenged almost 85% of DPPH free radical. On the other hand, this concentration had strong cytotoxic and genotoxic effect on TK6 cells.The balance between beneficial and harmful effects should be always considered when choosing the effective dose. Plants are universally recognized as a vital part of the world's natural heritage and up to 80% of the population relies on plants for their contribution to a primary healthcare. The use of plants in traditional medicine is widespread. Many plants still represent a large source of natural antioxidants that might serve as leads for the development of novel drugs. It is commonly accepted that due to oxidative stress, reactive oxygen species (ROS) such as superoxid, hydroxyl and peroxyl radicals are generated [1]. Recently much attention has been given to the natural phytochemicals with antioxidant, antimutagenic and anticarcinogenic activities [2][3][4][5][6][7][8]. These compounds are of great importance for chemoprevention and potential cancer biotherapy.Papaveraceae is a family of flowering plants. The flowers of poppy are chiefly employed as a mild pain reliever and as a treatment for irritable coughs; it also helps to reduce nervous over-activity [9]. The flowers and petals are anodyne, expectorant, hypnotic, slightly narcotic and sedative. An infusion is taken internally in the treatment of bronchial complaints and coughs, insomnia, poor digestion, nervous digestive disorders and minor painful conditions. The flowers are also used in the treatment of jaundice and -in very small quantities-as a sleep-inducing drug [9,10].Papaver rhoeas plant extract contains a lot of flavonoids: kaempferol, quercetin, luteolin and hypolaetin andAntioxidant activity of the kaempferol [12][13], quercetin [14][15] and luteolin [16] was already demonstrated. Total phenolic compounds (9.73 -19.91 mg GAE/g) and total flavonoids (7.904-11.45 mg QE/g) were determined in fresh petals [17].Besides flavonoids and their glycosides Papaveraceae family are known for the presence of alkaloids as morphine, codeine, narcotine, thebaine and papaverine [8,18,19].The aim of this study...

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confidence: 99%

Biological activity of plant extract isolated from Papaver rhoeas on human lymfoblastoid cell line

Hašplová¹,

Hudecová²,

Miadoková³

et al. 2011

neo

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“…The extraction yield was 15 g from 100 g of the dried petals of P. bracteatum. The soft extract was dissolved in normal saline and was immediately administered IP to the mice, expressed as mg of extract per kg body weight [14,15].…”

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confidence: 99%

“…The present study was designed to examine the possibility of an ameliorating action of the water-alcohol extract on doxorubicin-induced detrimental effects in mouse models, and implies that the extract may be a promising adjuvant agent that may attenuate the toxicity of doxorubicin. [14,15].…”

Section: Introductionmentioning

confidence: 99%

The effect of intra‐peritoneal administration of Papaver bracteatum Lindl. extract on development of NMRI mice oocytes treated with Doxorubicin

Jafarian

Eimani

Azarnia

et al. 2012

Reprod Medicine & Biology

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Purpose The effect of water-alcohol Papaver bracteatum Lindl. extract on development of mice oocytes treated with Doxorubicin (dox) was examined in this study. Methods The mice were classified into four groups. Control group, mice injected intraperitoneally (IP) with saline. Extract group alone, mice treated with 200 mg/kg of body weight (bw), IP, twelve consecutive days. Dox group alone, mice were given dox, IP, 10 mg/kg bw. Experimental group treated with extract and dox together. Effect of the extract on the development of mice oocytes treated with dox were evaluated through assisted reproductive technology techniques (ARTs). Results Developmental rate and blastocyst formation was improved by using the extract. A significant increase in in vitro developmental competence in comparison with dox group (P \ 0.05) was observed. Conclusions The results of this study indicated that P. bracteatum Lindl. extract could prevent dox toxicity of dox affecting both follicle or oocytes, and therefore it can result in improved embryo development which was observed in mice treated with dox plus P. bracteatum Lindl. compared to mice treated with dox alone.

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“…Our previous research has focused on the effects of P. rhoeas on expression and development of morphine dependence (Pourmotabbed et al, 2004) and morphineinduced conditioned place preference (Sahraei et al, 2006) in mice. It is necessary to investigate the effect of the extract of P. rhoeas on morphine-induced behavioral tolerance.…”

Section: Introductionmentioning

confidence: 99%

Effects ofPapaver rhoeas. Extract on the Development and Expression of Tolerance to Morphine-Induced Locomotor Activity in Mice

Sahraei

Shams

Faghih-Monzavi

et al. 2007

Pharmaceutical Biology

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In the current study, effects of a water-alcohol extract of Papaver rhoeas L.(Papaveraceae) on the acquisition and expression of morphine-induced behavioral tolerance in mice was investigated. Subcutaneous (s.c.) administration of morphine (50 mg=kg) induced locomotor activity in animals. Reduction of locomotor behavioral response in mice pretreated with morphine (50 mg=kg, twice daily for 3 days) alone indicates that tolerance had been developed. Extract (25, 50, and 100 mg=kg, i.p.) administration, 30 min before each of three daily doses of morphine, augmented the development of tolerance. Moreover, intraperitoneal administration of the plant extract (25, 50, and 100 mg=kg) 30 min before the test inhibited the expression of morphine-induced behavioral tolerance. The results indicate that administration of the extract of Papaver rhoeas induces different effects on the acquisition and expression of morphine-induced behavioral tolerance in mice.

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Effects of Papaver rhoeas extract on the acquisition and expression of morphine-induced conditioned place preference in mice

Cited by 40 publications

References 15 publications

Biological activity of plant extract isolated from Papaver rhoeas on human lymfoblastoid cell line

Biological activity of plant extract isolated from Papaver rhoeas on human lymfoblastoid cell line

The effect of intra‐peritoneal administration of Papaver bracteatum Lindl. extract on development of NMRI mice oocytes treated with Doxorubicin

Effects ofPapaver rhoeas. Extract on the Development and Expression of Tolerance to Morphine-Induced Locomotor Activity in Mice

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