Effects of parathyroid hormone and other proteins invitro on mitochondrial metabolism

Binding of Calcium by Liver Mitochondria: An Effect of Steroid Hormones in Vitamin D-Depleted and Parathyroidectomized Rats

“…The effects of parathyroidectomy on mitochondrial calcium binding occurred with concentrations of ATP between 0.75 and 2.0 HIM, in excess of the lower concentrations used to demonstrate the release of calcium following the in vitro addition of parathyroid hormone (7). One must also keep in mind the possibility that some of the in vitro effects of parathyroid hormone may not be specific (28). Finally, the effects of parathyroid hormone on mitochondrial metabolism may well differ drastically when one compares different tissues {e.g., liver vs. kidney), or when one compares the effects of in vitro addition to those of in vivo treatment (29,30).…”

Histones and Mitochondrial Ion Transport*

“…With regard to valinomycin-induced K+ efflux a major difference exists: the histone event is energy dependent while the antibiotic-stimulated efflux is completely independent of an energy source. A comparison of histone and parathyroid hormone is also of current interest in view of some recent suggestions that some of the effects of the hormone may be due to the presence of a basic protein (Aurbach et al, 1965). We have as yet been unable to carry out a detailed comparative study in this laboratory; however, some interesting aspects are available in the current literature.…”