1995
DOI: 10.1210/endo.136.8.7628353
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Effects of parathyroid hormone (PTH)-related protein and PTH on osteoclasts and osteoclast precursors in vivo.

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Cited by 34 publications
(17 citation statements)
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“…IL1, IL3, IL4, IL6, and IL11 and several CSFs, including MCSF, have been implicated in the control of osteoclast development (Jilka et al 1992;Lewis et al 1993;Girasole et al 1994). Systemic hormones, such as parathyroid hormone and Vitamin D3, and local factors like tumor necrosis factor, promote the development of osteoclasts through their ability to stimulate production of cytokines like IL6 and IL11 by osteoblasts or their precursors (Kitazawa et al 1994;De La Mata et al 1995;Uy et al 1995). OPG is a secreted regulator of osteoclast-mediated bone resorption, and the results of the current gene knockout study clearly implicate OPG as a physiological regulator of osteoclast-mediated bone resorption during postnatal bone growth and remodeling of the skeleton.…”
Section: Discussionmentioning
confidence: 99%
“…IL1, IL3, IL4, IL6, and IL11 and several CSFs, including MCSF, have been implicated in the control of osteoclast development (Jilka et al 1992;Lewis et al 1993;Girasole et al 1994). Systemic hormones, such as parathyroid hormone and Vitamin D3, and local factors like tumor necrosis factor, promote the development of osteoclasts through their ability to stimulate production of cytokines like IL6 and IL11 by osteoblasts or their precursors (Kitazawa et al 1994;De La Mata et al 1995;Uy et al 1995). OPG is a secreted regulator of osteoclast-mediated bone resorption, and the results of the current gene knockout study clearly implicate OPG as a physiological regulator of osteoclast-mediated bone resorption during postnatal bone growth and remodeling of the skeleton.…”
Section: Discussionmentioning
confidence: 99%
“…GSNOR -/-mice had higher serum levels of PTH and FGF23 and increased urinary loss of phosphate and calcium, which together can contribute to diminished bone density. Chronic PTH exposure increases osteoclast activity and bone resorp tion (44). Ongoing studies are underway to establish the relative contributions of altered hormonal homeostasis and increased PPARγ Snitrosylation to stem cell differentiation and the patho logical bone loss phenotypes.…”
Section: Methodsmentioning
confidence: 99%
“…28 Because MIP-1␣ also acts at the later stage of OCL formation, these data suggest that the enhanced effects of IL-6 on MIP-1␣-induced OCL formation most likely result from IL-6 increasing the size of the pool of early OCL precursors and MIP-1␣ inducing the differentiation and fusion of these precursors to form large numbers of OCLs. MIP-1␣ also enhanced the effects of PTHrP and RANKL on OCL formation, suggesting that it can enhance OCL formation by factors that also act at the later stage of OCL precursor differentiation, [28][29][30] and are produced by myeloma cells 31 or marrow stromal cells in response to myeloma cells.…”
Section: Mip-1␣ An Osteoclastogenic Factor Inmentioning
confidence: 95%