Effects of parsley (Petroselinum crispum) extract versus glibornuride on the liver of streptozotocin-induced diabetic rats

Saçan, Özlem; Yanardağ, Refiye; Orak, Haci; Ozgey, Yasemin; Yarat, Ayşen; Tunali, Tugba

doi:10.1016/j.jep.2005.08.069

Cited by 77 publications

(54 citation statements)

References 36 publications

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“…This result disagrees with the result obtained by [8] and [22]. [22] found that 3% onion powder reduced blood lipids, lipid peroxides and cholesterol.…”

Section: Effect Of Some Herbs In Boiler Diets On Blood Proteins and Lcontrasting

confidence: 99%

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Effect of Some Herbs in Boiler Diets on Blood Proteins and Lipids

Elagib¹,

Elamin²,

Abbas³

2016

IOSR

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“…This result disagrees with the result obtained by [8] and [22]. [22] found that 3% onion powder reduced blood lipids, lipid peroxides and cholesterol.…”

Section: Effect Of Some Herbs In Boiler Diets On Blood Proteins and Lcontrasting

confidence: 99%

“…Parsley had been used to treat nose bleeding, to regulate blood pressure, to treat eczema, knee ache, impotence [7]). Its seeds are used as diuretic and the hypoglycemic activity was shown by [8].…”

Section: Introductionmentioning

confidence: 99%

Effect of Some Herbs in Boiler Diets on Blood Proteins and Lipids

Elagib¹,

Elamin²,

Abbas³

2016

IOSR

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“…In modern medicine, parsley has been exhibited antioxidant, immunosuppressant, cytoprotective, diuretic, antibacterial and antifungal activities [73]. It is one of the most used medicinal plants to treat renal diseases [74], antihyperlipidemic, antihyperglycemic [75], and anti-microbial [76] [77] [78]. Parsley has been used as antiurolithiasis, antiseptic of the urinary tract, diuretic, anti-dote, and anti-inflammatory in folklore and traditional medicines [73].…”

Section: Parsley (Petroselinum Crispum)mentioning

confidence: 99%

Prevention of Nephropathy by Some Natural Sources of Antioxidants

Azab¹,

Albasha²,

Elsayed³

2017

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Nephrotoxicity is one of the most common kidney problems and occurs when the body is exposed to a drug or toxin. Natural sources of antioxidants may serve as a vital source of potentially useful new compounds for the development of an effective therapy to combat a variety of kidney problems. Natural antioxidants have a variety of biochemical actions such as inhibition of reactive oxygen species production, scavenging of free radicals. The present review aims to summarize the recent articles which studied some of the nephrotoxic agents, and alleviation of nephrotoxicity using of some natural products possessing antioxidant properties. Our review shows the oxidative damage and renal disorders induced in human and experimental animals by nephrotoxic agents such as gentamicin, alcohol, nicotine, adenine, glycerol, ethylene glycol, sodium nitrite, mercuric chloride, AlCl 3 , lead acetate, carbon tetrachloride (CCl 4 ), furosemide, carbendazim, diazinon, heat stress, and γ-radiation. Also, nephrotic disorders caused in diabetic rats, patients, cirrhotic ascetic patients, and ischemia-reperfusion. Administration of natural sources of antioxidants such as curcumin, garlic, fenugreek, parsley, peppermint, pomegranate, propolis, olive leaves, rosemary, and sesame attenuated both physiological and histopathological alterations induced in the kidney by the nephrotoxic agent and certain diseases. The nephroprotective effect of the former natural sources of antioxidants may be due to the enhancement of antioxidant activity and inhibition of tissue lipid peroxidation. It can be concluded that administration of curcumin, garlic, fenugreek, parsley, peppermint, pomegranate, propolis, olive leaves, rosemary, and sesame showed a remarkable kidney protection against nephrotoxic agents, and diseases induced renal dysfunctions in human and experimental animals. So, the present study recommended that the consumption of these natural sources of antioxidants may be useful for human exposure to nephrotoxic agents and patients who suffer from renal diseases.

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“…Increased NADH causes NADH oxidase to produce ROS (Chung et al, 2003). Decreased levels of GSH and activities of antioxidant enzymes (SOD, CAT, and GP x ) have been reported in different tissues and plasma of diabetic patients and animals (El Boghdady & Badr, 2012;Gumieniczek et al, 2009;Karthik & Ravikumar, 2011;Ozsoy-Sacan et al, 2006;Yanardag & Tunali, 2006). Similarly, in experimental diabetes, the pulmonary oxidative stress was present because of the reduction of antioxidant enzyme activity (Gumieniczek et al, 2002(Gumieniczek et al, , 2009Ozansoy et al, 2005).…”

Section: Discussionmentioning

confidence: 98%

Chard (Beta vulgarisvar.cicla) extract improved hyperglycemia-induced oxidative stress and surfactant-associated protein alterations in rat lungs

Öztay¹,

Saçan

Kayalar³

et al. 2015

Pharmaceutical Biology

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Context: Chard is used as an antidiabetic agent by the diabetic patients in Turkey. Objective: The effect of chard extract [Beta vulgaris L. var. cicla (Chenopodiaceae)] on the antioxidant system and the expression of surfactant-associated proteins (SP) in the lungs of hyperglycemic rats were examined. Materials and methods: Hyperglycemia was induced by a single dose of streptozotocin (60 mg/kg) provided intraperitoneally. Fourteen days after the rats were rendered hyperglycemic, the chard (2 g/kg/d), insulin (6 U/kg/d), and chard plus insulin (as mentioned above) were administered to rats for 45 d. On day 60, rats' lungs were removed. Oxidative stress parameters and SP expression were assayed. Results: The lungs of hyperglycemic rats were characterized by the induced lipid and protein oxidation, elevated myeloperoxidase and xanthine oxidase activities, decreased glutathione levels, and reduced tissue factor and antioxidant enzymes activities (catalase, superoxide dismutase, glutathione peroxidase, and glutathione-S-transferase). Chard treatment alone and chard treatment combined with insulin were capable of achieving a regression of pulmonary oxidative stress, by inhibiting lipid and protein oxidation, and restoring the antioxidant system of hyperglycemic rats. SP-A expressions were significantly unchanged in all groups, whereas pro-SP-C and SP-D expressions were reduced in hyperglycemic rats. Pro-SP-C and SP-D levels were increased by chard and insulin administrations alone and combined in hyperglycemic rats. Discussion and conclusion: All treatments have a positive effect on the surfactant and antioxidant systems of the lungs of hyperglycemic rats. The best therapeutic effect was provided by treatment with chard extract alone in the compensation of hyperglycemic symptoms.

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Effects of parsley (Petroselinum crispum) extract versus glibornuride on the liver of streptozotocin-induced diabetic rats

Cited by 77 publications

References 36 publications

Effect of Some Herbs in Boiler Diets on Blood Proteins and Lipids

Effect of Some Herbs in Boiler Diets on Blood Proteins and Lipids

Prevention of Nephropathy by Some Natural Sources of Antioxidants

Chard (Beta vulgarisvar.cicla) extract improved hyperglycemia-induced oxidative stress and surfactant-associated protein alterations in rat lungs

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