Effects of pelvic nerve and pudendal nerve transection on mating behavior in the male rat

Lodder, J.; Zeilmaker, G. H.

doi:10.1016/0031-9384(76)90245-6

Cited by 54 publications

(17 citation statements)

References 20 publications

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“…These data collected validate the DPN stimulation model for investigation of processes involved with ejaculatory reflexes. In further support, bilateral transection of the DPN has been observed to prevent ejaculation in mating rats [23], and ejaculatory reflexes can be elicited by electrical or vibratory stimulation of the DPN in rats18 and men [24]. As a result of stimulation, the BCM undergoes rhythmic contractions similar to those in a behaving animal, and reflexive penile erections are evident [18,25].…”

Section: Discussionmentioning

confidence: 84%

Activation of MAP Kinase in Lumbar Spinothalamic Cells Is Required for Ejaculation

Staudt

Oliveira

Lehman

et al. 2010

The Journal of Sexual Medicine

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Introduction Ejaculation is a reflex controlled by a spinal ejaculation generator located in the lumbosacral spinal cord responsible for the coordination of genital sensory with autonomic and motor outputs that regulate ejaculation. In the male rat, a population of lumbar spinothalamic cells (LSt cells) comprises an essential component of the spinal ejaculation generator. LSt cells are activated with ejaculation, but the nature of the signal transduction pathways involved in this activation is unknown. Moreover, it is unknown if LSt cell activation is required for expression of ejaculation. Aim The current study tested the hypothesis that ejaculatory reflexes are triggered via activation of the mitogen-activated protein (MAP) kinase signaling pathway in the LSt cells. Methods Expression of phosphorylated extracellular signal-related kinases 1 and 2 (pERK) was investigated following mating behavior, or following ejaculation induced by electrical stimulation of the dorsal penile nerve (DPN) in anesthetized, spinalized male rats. Next, the effects of intrathecal or intraspinal delivery of Mitogen-activated protein/extracellular signal-regulated kinase (MEK) inhibitor U0126 on DPN stimulation-induced ejaculation was examined. Main Outcome Measures Expression of pERK in LSt cells and associated areas was analyzed. Electromyographic recordings of the bulbocavernosus muscle were recorded in anesthetized, spinalized rats. Results Results indicate that the MAP kinase signaling pathway is activated in LSt cells following ejaculation in mating animals or induced by DPN stimulation in anesthetized, spinalized animals. Moreover, ERK activation in LSt cells is an essential trigger for ejaculation, as DPN stimulation-induced reflexes were absent following administration of MEK inhibitor in the L3-L4 spinal area. Conclusion These data provide insight into the nature of the signal transduction pathways involved in the activation of ejaculation through LSt cells. The data demonstrate that ERK activation in LSt cells is essential for ejaculation and contribute to a more detailed understanding of the spinal generation of ejaculation.

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Section: Discussionmentioning

confidence: 84%

Activation of MAP Kinase in Lumbar Spinothalamic Cells Is Required for Ejaculation

Staudt

Oliveira

Lehman

et al. 2010

The Journal of Sexual Medicine

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“…The DPN is the primary afferent that transmits sensory information related to the summation of mating to the spinal ejaculation generator and triggers ejaculation [52,53]. Indeed, bilateral transection of the DPN blocks ejaculation in mating rats [54]. Although the pathways whereby sensory information is transmitted from the DPN to the LSt cells are currently unknown, it has been shown that DPN nerve fibers terminate in the lower lumbar and upper sacral levels of the spinal cord in the general vicinity of the LSt cells, dorsal horn and dorsal grey commissure (DCG) [31,52,55].…”

Section: Discussionmentioning

confidence: 99%

Activation of Gastrin-releasing Peptide Receptors in the Lumbosacral Spinal Cord is Required for Ejaculation in Male Rats

Kozyrev

Lehman

Coolen

2012

The Journal of Sexual Medicine

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“…After intrathecal administration, however, the failure to ejaculate may have been due to a decreased proportion of mounts which resulted in vaginal penetration. A similar decrease in intromlsslon ratio occurs after functional deafferentation of the penis, which impairs the abdity to locate the vaginal orifice [2, 135,193]. Thus, spinal serotonerglc fibers may inhibit the transmission of penile sensory information and/or the motor nuclei regulating penile reflexes.…”

Section: Lo(ahzatum Of 5-ht Lffect~ Ascending Raphe Axonsmentioning

confidence: 99%

Pharmacological analysis of male rat sexual behavior

Bitran

Hull

1987

Neuroscience & Biobehavioral Reviews

409

155

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Effects of pelvic nerve and pudendal nerve transection on mating behavior in the male rat

Cited by 54 publications

References 20 publications

Activation of MAP Kinase in Lumbar Spinothalamic Cells Is Required for Ejaculation

Activation of MAP Kinase in Lumbar Spinothalamic Cells Is Required for Ejaculation

Activation of Gastrin-releasing Peptide Receptors in the Lumbosacral Spinal Cord is Required for Ejaculation in Male Rats

Pharmacological analysis of male rat sexual behavior

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