2016
DOI: 10.1016/j.ejogrb.2015.12.016
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Effects of pentoxifylline and platelet activating factor on sperm DNA damage

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Cited by 21 publications
(13 citation statements)
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“…15 An important technique used to differentiate the live spermatozoa is the use of pentoxifylline. The concern about the chromatin damage caused by pentoxifylline use, as described by Unsal et al 10 make this study very useful for assisted reproduction routines. Accordingly to our results, the use of pentoxifylline in 1.5mM concentration does not affect the genetic material of the patient, even when DNA fragmentation rates are higher.…”
Section: Discussionmentioning
confidence: 91%
See 1 more Smart Citation
“…15 An important technique used to differentiate the live spermatozoa is the use of pentoxifylline. The concern about the chromatin damage caused by pentoxifylline use, as described by Unsal et al 10 make this study very useful for assisted reproduction routines. Accordingly to our results, the use of pentoxifylline in 1.5mM concentration does not affect the genetic material of the patient, even when DNA fragmentation rates are higher.…”
Section: Discussionmentioning
confidence: 91%
“…With the inhibition of the phosphodiesterase, there is an increase in the available AMPc levels, resulting in larger amount of active PK-A, which leads to a gain of sperm motility. 9 However, a question raised by Unsal et al 10 is the chance of DNA damage induced by pentoxifylline. The presence of fragmentation in the chromatin may have a negative impact on fertility rates, particularly in ICSI.…”
Section: /7mentioning
confidence: 99%
“…Ap4A also serves as an alarmone for heat stress in E. coli (24). Whether Ap4A plays a role in S. aureus DNA damage caused by PLTs is not yet clear; however, it has been reported that the PLT-activating factor (PAF) derived from PLT transfusion, which is used to increase sperm motility in embryology laboratories, was proven to damage the DNA of sperm (25). In another study, PAF could also arrest the proliferation of human mast cells.…”
Section: Discussionmentioning
confidence: 99%
“…There is no similar study that confirms these results. Although there are different studies that have concluded that some reagents such as PVP (Salian, Kalthur, Uppangala, Kumar, & Adiga, 2012), pentoxifylline and platelet‐activating factor (Unsal et al., 2016), and sodium nitroprusside (Santiso et al., 2012) can damage the DNA of spermatozoa in a short period of time, we do not know the exact mechanism causing the DNA fragmentation elevation. One of the critical materials in ELB is ammonium.…”
Section: Discussionmentioning
confidence: 95%