Effects of Peptides and Amino Acids Derived from Oyster on Blood Lipids

Abstract

Objectives: The objective of this study is to demonstrate the effect on blood lipids in humans, of a supplement which contained peptides and amino acids originating from oyster meat. Methods: Proteins in oyster meat were hydrolyzed by enzymes, followed by preparing oyster meat extract powder containing the peptides and free amino acids as a supplement. We performed the following 2 clinical trials in which male and female adults with dyslipidemia received the oyster meat supplement for specified periods; in the first open label trial, the oyster meat supplement was given to 14 subjects (average age 48.7years old) for 8weeks, while in the second crossover controlled trial, the oyster meat supplement and its placebo were taken by 19 subjects (average age 52.4years old) for 4weeks, respectively. In these trials, the effect of the supplement on blood lipids was evaluated by conducting serum chemistry and body composition measurement before and after taking the supplement Results: In the open label trial, at the end of Week 4 from the start of taking the supplement, a decrease of very low-density lipoprotein (VLDL) and an increase of high-density lipoproteins (HDL) in blood lipoproteins were observed with statistically significant difference (P<0.01). In the crossover placebo-controlled study, we confirmed the reduction of the ratio of VLDL in lipoproteins (P=0.04), the increase of HDL cholesterol (P=0.02), and the suppression of the elevation of triglycerides (TG) (P=0.02) Week 4after the start of taking of the supplement. Conclusion: The oyster meat extract powder was most likely to have potential utilities in the management of dyslipidemia.

Anti-Fatigue Action of Peptides and Amino Acids Derived from Oyster on Healthy Subjects

“…In addition, a clinical study on hyperlipidemia patients who took the oyster meat extract powder indicates the possibilities of the normalization of blood lipid levels and the activation of body protein synthesis. 23 As one of the mechanisms by which fatigue is prolonged, the contribution of decrease in functions of the liver and other organs is suggested; thus, by the function reduction, energy metabolism in organs including the liver does not advance smoothly, the lack of energy occurs in a body, and thereby the restoration of cell functions and new protein synthesis are inhibited. 24 Based on these results, the decrease of fatigue confirmed in this study is probably attributable to the stimulation of energy metabolism and body protein synthesis by the intake of the oyster meat extract powder.…”

“…Nutrient components and components derived from oyster meat extract powder obtained by enzyme hydrolysis in 12 test supplement tablets (sugarcoated tablet, 480mg each) for daily use, and distribution of peptide in oyster meat extract powder by enzyme hydrolysis23 …”