Effects of perfluorooctanoic acid — a potent peroxisome proliferator in rat — on Morris hepatoma 7800C1 cells, a rat cell line

Sohlenius, Anna‐Karin; Andersson, Karin; Bergstrand, Anders; Spydevold, Øystein; DePierre, Joseph W.

doi:10.1016/0005-2760(94)90223-2

Cited by 31 publications

(15 citation statements)

References 27 publications

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“…Protective values, the benchmark internal concentrations (BMICs), were chosen as "points of departure" for risk characterization (24). Three values, (1) 33 µg/mL, derived from the lower 95% confidence limit of the BMIC based on rat pup weight gain during lactation (24), (2) 44 µg/mL, the NOAEL of the rat liver toxicity (24,25), and (3) 62 µg/mL, the lower 95% confidence limit of the BMIC (10% response) for liver tumor formation in rats (25), were used in the risk evaluation of serum PFOS concentrations in the Chinese population. A similar approach has also been adopted in another study (23).…”

Section: Concentrations Of Pfcs In Blood Samples From Chinamentioning

confidence: 99%

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Perfluorooctanesulfonate and Related Fluorochemicals in Human Blood Samples from China

Yeung

Jiang

et al. 2005

Environ. Sci. Technol.

326

219

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Perfluorooctanesulfonylfluoride (POSF)-based compounds have been manufactured and used in a variety of industrial applications. These compounds degrade to perfluorooctanesulfonate (PFOS) which is regarded as a persistent endstage metabolite and is found to accumulate in tissues of humans and wildlife. PFOS, perfluorohexanesulfonate (PFHxS), perfluorooctanoate (PFOA), and perfluorooctanesulfonamide (PFOSA) have been found in human sera from the United States. In this study, concentrations of PFHxS, perfluorobutanesulfonate (PFBS), PFOS, perfluorohexanoic acid (PFHxA), PFOA, perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), perfluoroundecanoic acid (PFUnDA), perfluorododecanoic acid (PFDoDA), and PFOSA were measured in 85 samples of whole human blood collected from nine cities (eight provinces) in China, including Shenyang (Liaoning), Beijing (Hebei), Zhengzhou (Henan), Jintan (Jiangsu), Wuhan (Hubei), Zhoushan (Zhejiang), Guiyang (Guizhou), Xiamen (Fujian), and Fuzhou (Fujian). Among the 10 perfluorinated compounds (PFCs) measured, PFOS was the predominant compound. The mean concentration of PFOS was greatest in samples collected from Shenyang (79.2 ng/mL) and least in samples from Jintan (3.72 ng/mL). PFHxS was the next most abundant perfluorochemical in the samples. No age-related differences in the concentrations of PFOA, PFOS, PFOSA, and PFHxS were observed. Gender-related differences were found, with males higher for PFOS and PFHxS, and females higher in PFUnDA. Concentrations of PFHxS were positively correlated with those of PFOS, while concentrations of PFNA, PFDA, and PFUnDA were positively correlated with those of PFOA. There were differences in the concentration profiles (percentage composition) of various PFCs in the samples among the nine cities.

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Section: Concentrations Of Pfcs In Blood Samples From Chinamentioning

confidence: 99%

“…The strong carbonfluorine (C-F) covalent bonds in PFCs account for the thermal and chemical stability of these compounds, which have been manufactured and used in a variety of industrial applications, such as surfactants and surface protectors, for over 50 years (2)(3)(4).…”

Section: Introductionmentioning

confidence: 99%

Perfluorooctanesulfonate and Related Fluorochemicals in Human Blood Samples from China

Yeung

Jiang

et al. 2005

Environ. Sci. Technol.

326

219

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“…The numerous effects that high-dose, short-term exposure to these compounds have on rodents, characterized in our own laboratory (Sohlenius et al, 1992(Sohlenius et al, , 1993(Sohlenius et al, , 1994 and others (Kissa, 2001;Lau et al, 2007;Martin et al, 2007;Andersen et al, 2008), include pronounced hepatomegaly and peroxisome proliferation; reduced appetite and loss of body weight and fat; changes in hormonal status; reproductive and neurotoxicity; as well as, following long-term exposure, hepatocarcinogenesis.…”

Section: Introductionmentioning

confidence: 97%

High-dose, short-term exposure of mice to perfluorooctanesulfonate (PFOS) or perfluorooctanoate (PFOA) affects the number of circulating neutrophils differently, but enhances the inflammatory responses of macrophages to lipopolysaccharide (LPS) in a similar fashion

et al. 2009

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“…The strong carbonfluorine (C-F) covalent bond in PFCs accounts for the thermal and chemical stability of these compounds, which have been manufactured and used for a variety of industrial applications, such as surfactants and surface protectors, for over 50 years [2][3][4] . The ubiquitous occurrence of PFCs in environmental samples has drawn much attention [4] .…”

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confidence: 99%

Perfluorooctane sulfonate (PFOS) and related fluorochemicals in chicken egg in China

et al. 2008

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The ubiquitous occurrence of perfluorinated compounds (PFCs) in environmental samples has drawn much attention. Recent human exposure studies found relatively high perfluorooctane sulfonate (PFOS) concentrations in blood samples from several cities in China when compared with other countries. The objectives of the present study were: (1) to measure PFC concentrations and compositions in chicken egg samples from local markets in China; and (2) to conduct a preliminary human health risk assessment of egg consumption. Eight pooled egg samples from eight locations were analyzed for 11 PFCs. The results showed that close to 100% of the PFOS in the egg was distributed in egg yolk and PFOS was not detected in egg white (<0.08 ng/g wet weight, w/w). Of the perfluoroalkylsulfonates, only PFOS was detected in all egg samples, while of the perfluoroalkylcarboxylates, perfluoroundecanoic acid (PFUnDA) was detected in all samples, followed by perfluorooctanoate (PFOA) (75% occurrence) and perfluorodecanoic acid (PFDA) (50% occurrence). PFOS concentrations in egg ranged from 45.0 to 86.9 ng/g w/w. The results suggested that current concentrations of PFOS in domestic chicken eggs are unlikely to cause immediate harm to Chinese populations.PFOS, chicken egg, human health risk assessment, egg yolk, egg white Perfluorooctanesulfonate (PFOS), one of the most wellknown perfluorinated compounds (PFCs), is the endstage metabolite of many PFCs [1] . The strong carbonfluorine (C-F) covalent bond in PFCs accounts for the thermal and chemical stability of these compounds, which have been manufactured and used for a variety of industrial applications, such as surfactants and surface protectors, for over 50 years [2][3][4] . The ubiquitous occurrence of PFCs in environmental samples has drawn much attention [4] . In 2000, one of the fluorochemical manufacturing companies, the 3M Company, ceased the production of perfluorooctanyl-related materials because PFOS was found to be present in tissues of humans and wildlife [5] .Recent studies have demonstrated PFC contamination in China. PFCs were detected in the coastal seawaters of Hong Kong and the Zhujiang River Delta, as well as in waters from the Zhujiang and Yangtze rivers [6][7][8] . PFCs were also measured in seafood samples collected from Zhoushan and Guangzhou [9] and in mussel samples collected along the eastern coast of China [10] . Human exposure studies also showed relatively high PFOS concentrations in blood samples from several cities in China when compared with other countries [11,12] .Although there is no toxicological study of PFOS in humans thus far, the toxicity of PFOS has been studied in rats, mice, rabbits, and monkeys [13][14][15][16][17][18][19] . Reduced body weight, hepatocellular hypertrophy, and a decrease in serum cholesterol and triglycerides were observed in rats

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Effects of perfluorooctanoic acid — a potent peroxisome proliferator in rat — on Morris hepatoma 7800C1 cells, a rat cell line

Cited by 31 publications

References 27 publications

Perfluorooctanesulfonate and Related Fluorochemicals in Human Blood Samples from China

Perfluorooctanesulfonate and Related Fluorochemicals in Human Blood Samples from China

High-dose, short-term exposure of mice to perfluorooctanesulfonate (PFOS) or perfluorooctanoate (PFOA) affects the number of circulating neutrophils differently, but enhances the inflammatory responses of macrophages to lipopolysaccharide (LPS) in a similar fashion

Perfluorooctane sulfonate (PFOS) and related fluorochemicals in chicken egg in China

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