Effects of Peritoneal Dialysis Solution on Experimental Necrotizing Enterocolitis in Newborn Rats

Cömert, Hatice Sonay Yalçın; Sarıhan, Haluk; Sayğın, İsmail; İmamoğlu, Mustafa; Başar, Dilek; Çan, Gamze

doi:10.1007/s42399-019-00079-0

Cited by 3 publications

(1 citation statement)

References 24 publications

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“…NEC is one of the most important causes of morbidity and mortality in neonatal intensive care units [1][2][3]. It affects 4-13% of infants have low birth weight (<1500 g) and 1-8% of infants admitted to neonatal intensive care units [4,5].…”

Section: Introductionmentioning

confidence: 99%

Dual energy CT in necrotizing enterocolitis; a novel diagnostic approach

Çağlar¹,

Cesur²,

Sade³

et al. 2021

Turk J Med Sci

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Background/Aim: Necrotizing enterocolitis (NEC) is one of the most important causes of morbidity and mortality in premature infants. Although there are no specific diagnostic tools, the main factors affecting prognosis are clinical and laboratory findings, and early diagnosis and treatment. In this study, we demonstrate the importance of dual-energy computed tomography (DECT) in confirming intestinal ischemia in neonates with NEC. Materials and Methods:Patients diagnosed with NEC in a neonatal intensive care unit were staged according to modified Bell's classification, and DECT was performed on patients with NEC stages 2-A, 2-B and 3-A. According to their DECT reports, these patients were then separated into two groups: those with intestinal ischemia and those without intestinal ischemia.The patients with intestinal ischemia were evaluated using surgical reports, and the other patients were evaluated using clinical findings.Results: DECT was performed in 21 patients with NEC stages 2-A, 2-B and 3-A. Twelve patients (57.1%) without ischemia were followed up without surgery. Nine patients (42.9%) with ischemia on DECT were operated on, and resection and anastomosis or ileostomy and colostomy were performed. Conclusions:In patients with NEC, DECT significantly increases overall diagnostic confidence in assessing intestinal necrosis when compared with traditional diagnostic methods.

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Section: Introductionmentioning

confidence: 99%

Dual energy CT in necrotizing enterocolitis; a novel diagnostic approach

Çağlar¹,

Cesur²,

Sade³

et al. 2021

Turk J Med Sci

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show abstract

What animal model should I use to study necrotizing enterocolitis?

Won

Mladenov

Raymond

et al. 2023

Seminars in Pediatric Surgery

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A Clinical Case of Continuous Flow Peritoneal Dialysis in a One-Month Old Child With Acute Renal Damage and Necrotizing Enterocolitis

Rekhviashvili

Makulova

Chashchukhina

et al. 2020

Russian Journal of Pediatric Surgery

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Necrotizing enterocolitis of newborns (NEC) is a severe intestinal disease that occurs against the background of acute hypoxia, violations of normal colonization of the intestine by microflora, leading to necrosis and perforation of the intestinal wall, peritonitis. Frequency of occurrence of 1-5 cases per 1000 live-born children. Most often, premature babies and children with low birth weight get sick. The development of NEC in a child significantly worsens the prognosis and increases mortality. Modern development of medical technology has made it possible to provide assistance to extremely premature newborns, which has led to an increase in the number of patients with NEC who are in a critical condition due to the course of multi-organ failure, including kidney failure, which requires renal replacement therapy (RRT). The main method of RRT used in newborns and young children is peritoneal dialysis (PD). NEC in the initial stages is considered an absolute contraindication for performing invasive manipulations on the abdominal cavity, since the risk of disease progression with the development of complications requiring surgical intervention increases at times. Recently, peritoneal dialysis has also become widespread in deeply premature newborns, who are the main risk group for developing NEC. Peritoneal dialysis in the continuous flow modification eliminates high intra-abdominal tension, one of the provoking factors for the progression of NEC, and in foreign expert studies, there are reports that the dialysis solution improves the intestinal wall trophism. This article presents a clinical case of peritoneal dialysis in flow modification in a 1-month-old child with acute renal damage and necrotizing enterocolitis.

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Effects of Peritoneal Dialysis Solution on Experimental Necrotizing Enterocolitis in Newborn Rats

Cited by 3 publications

References 24 publications

Dual energy CT in necrotizing enterocolitis; a novel diagnostic approach

Dual energy CT in necrotizing enterocolitis; a novel diagnostic approach

What animal model should I use to study necrotizing enterocolitis?

A Clinical Case of Continuous Flow Peritoneal Dialysis in a One-Month Old Child With Acute Renal Damage and Necrotizing Enterocolitis

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