Effects of pH on salicylic acid toxicity in terms of biomarkers determined in the marine gastropod Gibbula umbilicalis

Dionísio, Ricardo; Daniel, David; Arenas, Francisco; Campos, João C.; Costa, Paulo; Nunes, Bruno; Correia, Alberto Teodorico

doi:10.1016/j.marenvres.2020.104995

Cited by 11 publications

(3 citation statements)

References 109 publications

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“…Therefore, the inhibition of AChE activity observed in the OA treatments were perhaps related to increased concentrations of GABA neurotransmitters. Similarly, a study conducted by Dionísio et al (2020) showed that AChE activity of the marine gastropod Gibbula umbilicalis could be inhibited after exposure to acidified seawater. By contrast, OW led to increased AChE activity in T. niloticus held at both pH 8.1 and pH 7.6.…”

Section: Effects Of Oa And/or Ow On Ache Activity Of T Niloticusmentioning

confidence: 88%

Risks to the stability of coral reefs in the South China Sea: An integrated biomarker approach to assess the physiological responses of Trochus niloticus to ocean acidification and warming

Zhang

et al. 2021

Science of The Total Environment

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Section: Effects Of Oa And/or Ow On Ache Activity Of T Niloticusmentioning

confidence: 88%

Risks to the stability of coral reefs in the South China Sea: An integrated biomarker approach to assess the physiological responses of Trochus niloticus to ocean acidification and warming

Zhang

et al. 2021

Science of The Total Environment

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“…Animals were exposed similarly to what was described in [44] and as shown in Scheme 1. Briefly, 12 L plastic boxes were used and divided into 3 compartments (pseudoreplicates), where 7 animals were exposed per compartment, for a total of 21 animals per treatment.…”

Section: Experimental Designmentioning

confidence: 99%

“…Despite being a generic principle that is especially valid for simple processes (cellular and organ levels), this seems also to be valid for the environmental processes of absorption of toxicants from external media. Previous studies have shown the effect of pH on the absorption and toxicity of several contaminants [43,44]. Consequently, and assuming the characteristics of PAR (which has been classified as a weak acid [45]), lower pH values may enhance the absorption (and the toxicity) of this drug.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Paracetamol Toxic Effects under Varying Seawater pH Conditions on the Marine Polychaete Hediste diversicolor Using Biochemical Endpoints

Daniel

Nunes

Pinto

et al. 2022

Biology

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Increasing atmospheric carbon dioxide (CO2) levels are likely to lower ocean pH values, after its dissolution in seawater. Additionally, pharmaceuticals drugs are environmental stressors due to their intrinsic properties and worldwide occurrence. It is thus of the utmost importance to assess the combined effects of pH decreases and pharmaceutical contamination, considering that their absorption (and effects) are likely to be strongly affected by changes in oceanic pH. To attain this goal, individuals of the marine polychaete Hediste diversicolor were exposed to distinct pH levels (8.2, 7.9, and 7.6) and environmentally relevant concentrations of the acidic drug paracetamol (PAR: 0, 30, 60, and 120 µg/L). Biomarkers such as catalase (CAT), glutathione S-transferases (GSTs), acetylcholinesterase (AChE), and cyclooxygenase (COX) activities, as well as peroxidative damage (through thiobarbituric acid reactive substance (TBARS) quantification), were quantified to serve as ecotoxicological endpoints. Data showed a general increase in CAT and a decrease in GST activities (with significant fluctuations according to the tested conditions of PAR and pH). These changes are likely to be associated with alterations of the redox cycle driven by PAR exposure. In addition, pH levels seemed to condition the toxicity caused by PAR, suggesting that the toxic effects of this drug were in some cases enhanced by more acidic conditions. An inhibition of AChE was observed in animals exposed to the highest concentration of PAR, regardless of the pH value. Moreover, no lipid peroxidation was observed in most individuals, although a significant increase in TBARS levels was observed for polychaetes exposed to the lowest pH. Finally, no alterations of COX activities were recorded on polychaetes exposed to PAR, regardless of the pH level. The obtained results suggest that seawater acidification is detrimental to marine wildlife, since it may enhance toxic effects caused by environmental realistic concentrations of acidic drugs, such as PAR. This work was crucial to evidence that ocean acidification, in the context of a global change scenario of increased levels of both atmospheric and oceanic CO2, is a key factor in understanding the putative enhanced toxicity of most pharmaceutical drugs that are of an acidic nature.

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Evaluation of single and combined effects of two pharmaceuticals on the marine gastropod Phorcus lineatus enzymatic activity under two different exposure periods

Daniel

Nunes

2021

Ecotoxicology

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Effects of pH on salicylic acid toxicity in terms of biomarkers determined in the marine gastropod Gibbula umbilicalis

Cited by 11 publications

References 109 publications

Risks to the stability of coral reefs in the South China Sea: An integrated biomarker approach to assess the physiological responses of Trochus niloticus to ocean acidification and warming

Risks to the stability of coral reefs in the South China Sea: An integrated biomarker approach to assess the physiological responses of Trochus niloticus to ocean acidification and warming

Assessment of Paracetamol Toxic Effects under Varying Seawater pH Conditions on the Marine Polychaete Hediste diversicolor Using Biochemical Endpoints

Evaluation of single and combined effects of two pharmaceuticals on the marine gastropod Phorcus lineatus enzymatic activity under two different exposure periods

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