Effects of pH on the stability and compressibility of DPPC/cholesterol monolayers at the air–water interface

Gong, Ke; Feng, Si‐Shen; Go, Mei‐Lin; Soew, Pei Hsing

doi:10.1016/s0927-7757(02)00043-2

Cited by 136 publications

(112 citation statements)

References 28 publications

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“…This indicates that mixed cholesterol/phospholipid monolayers are more rigid as compared to pure DPPC films. This condensing effect of cholesterol on lipid monolayes is well known and has been frequently described in literature [15,21,39].…”

Section: Cholesterol-dppc/dopc Mixtures 1 A) Surface Pressure Isothermsmentioning

confidence: 73%

“…In fact, mixed monolayers of phospholipids and sterols, mainly cholesterol, have already been investigated [15,16], however, we are interested in a detailed study of mixed systems where the proportion of sterols to phospholipids coincides with that of natural membrane. Mammalian membranes contain high proportion of phosphatidylcholines (PC), both saturated and unsaturated [17].…”

mentioning

confidence: 99%

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Interactions between membrane sterols and phospholipids in model mammalian and fungi cellular membranes — A Langmuir monolayer study

Miñones

País

Conde

et al. 2009

Biophysical Chemistry

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To cite this version:J. Miñones, S. Pais, O. Conde, P. Dynarowicz-Łątka. Interactions between membrane sterols and phospholipids in model mammalian and fungi cellular membranes -A Langmuir monolayer study. Biophysical Chemistry, Elsevier, 2009, 140 (1-3) This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. A C C E P T E D

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Section: Cholesterol-dppc/dopc Mixtures 1 A) Surface Pressure Isothermsmentioning

confidence: 73%

mentioning

confidence: 99%

Interactions between membrane sterols and phospholipids in model mammalian and fungi cellular membranes — A Langmuir monolayer study

Miñones

País

Conde

et al. 2009

Biophysical Chemistry

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“…The self-assembled bilayer comes with its physical properties and abilities. Even in a naked lipid bilayer, lateral forces profile respond to deformation (10), heat (96), pH (97), ions (98), chemical modifications by light (99), etc. It could work as an elementary sensor in response to changes, including osmotic changes, in the violent primordial soup.…”

Section: The Originmentioning

confidence: 99%

Feeling the hidden mechanical forces in lipid bilayer is an original sense

Anishkin

Loukin²,

Teng³

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

263

216

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Life's origin entails enclosing a compartment to hoard material, energy, and information. The envelope necessarily comprises amphipaths, such as prebiotic fatty acids, to partition the two aqueous domains. The self-assembled lipid bilayer comes with a set of properties including its strong anisotropic internal forces that are chemically or physically malleable. Added bilayer stretch can alter force vectors on embedded proteins to effect conformational change. The force-from-lipid principle was demonstrated 25 y ago when stretches opened purified Escherichia coli MscL channels reconstituted into artificial bilayers. This reductionistic exercise has rigorously been recapitulated recently with two vertebrate mechanosensitive K + channels (TREK1 and TRAAK). Membrane stretches have also been known to activate various voltage-, ligand-, or Ca 2+ -gated channels. Careful analyses showed that Kv, the canonical voltage-gated channel, is in fact exquisitely sensitive even to very small tension. In an unexpected context, the canonical transient-receptor-potential channels in the Drosophila eye, long presumed to open by ligand binding, is apparently opened by membrane force due to PIP 2 hydrolysis-induced changes in bilayer strain. Being the intimate medium, lipids govern membrane proteins by physics as well as chemistry. This principle should not be a surprise because it parallels water's paramount role in the structure and function of soluble proteins. Today, overt or covert mechanical forces govern cell biological processes and produce sensations. At the genesis, a bilayer's response to osmotic force is likely among the first senses to deal with the capricious primordial sea. mechanosensitivity | force sensing | channel gating | bilayer mechanics | touch

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“…Valores altos de C s -1 indicam elasticidade interfacial baixa (Gong et al, 2002) (Khattari et al, 2011). Gráficos de C s ou C s -1 podem ser traçados em função da área por molécula ou mesmo da pressão de superfície, e são especialmente úteis na determinação das próprias fases da isoterma de um composto e também na determinação de regiões de transição de fase.…”

Section: Propriedades Mecânicas: Elasticidade Superficial Estática E unclassified

“…Portanto, as monocamadas são fluidas e suas compressibilidades são grandes. Além disto, pode-se dizer que os filmes apresentam elasticidade interfacial alta já que os valores de C s -1 são pequenos em toda a extensão do gráfico (GONG et al, 2002) (Sabatini et al, 2008).…”

Section: Filmes De Langmuir Dos éSteres De Polietilenoglicolunclassified

Filmes De Langmuir De Ésteres De Polietilenoglicol Derivados De Ácidos Graxos

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Effects of pH on the stability and compressibility of DPPC/cholesterol monolayers at the air–water interface

Cited by 136 publications

References 28 publications

Interactions between membrane sterols and phospholipids in model mammalian and fungi cellular membranes — A Langmuir monolayer study

Interactions between membrane sterols and phospholipids in model mammalian and fungi cellular membranes — A Langmuir monolayer study

Feeling the hidden mechanical forces in lipid bilayer is an original sense

Filmes De Langmuir De Ésteres De Polietilenoglicol Derivados De Ácidos Graxos

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