Effects of Phosphatidylserine in Age-Associated Memory Impairment and Alzheimer’s Disease

CrookIII, Thomas H.; Tinklenberg, Jared R.; Yesavage, Jerome A.; Petrie, William M.; Wells, Charles E.; Nunzi, Maria Grazia; Massari, D.

doi:10.1007/978-1-4615-3432-7_17

Cited by 37 publications

(51 citation statements)

References 21 publications

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“…Milk fat globule membrane (MFGM) phospholipids have been shown to have a number of health benefits [4,5,8,9,15], and MFGM material may be successfully used to stabilize emulsions [3,20,21,32] and produce liposomes [29].…”

Section: Introductionmentioning

confidence: 99%

Comparison of hydrophobic and hydrophilic encapsulation using liposomes prepared from milk fat globule-derived phospholipids and soya phospholipids

Thompson

Couchoud

Singh

2009

Dairy Sci. Technol.

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-Liposomes prepared from a milk fat globule membrane (MFGM) phospholipid fraction have been shown to have significantly different physical and chemical characteristics and appeared to be more stable in a variety of conditions than liposomes prepared from soya phospholipid material. These liposome systems were used to try to encapsulate model hydrophobic (β-carotene) and hydrophilic (potassium chromate) compounds. Liposomes produced from the MFGM-derived phospholipids showed significantly higher entrapment efficiencies for both β-carotene and potassium chromate. The differences were particularly apparent when using the hydrophobic molecules at low ratios of β-carotene to phospholipid. It is likely that the improved incorporation efficiency for β-carotene is due to the partitioning of the molecule between the aqueous phase and the phospholipid membrane, a property which will be dependent on the specific composition of the phospholipid material used. The higher encapsulation efficiency for the potassium chromate appeared to reflect the slightly larger diameter of the liposomes produced from the MFGM material. These results suggest that there may be inherent advantages in the use of liposomes prepared from MFGM-derived phospholipids via microfluidization for the encapsulation of both hydrophobic and hydrophilic compounds.

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Section: Introductionmentioning

confidence: 99%

Comparison of hydrophobic and hydrophilic encapsulation using liposomes prepared from milk fat globule-derived phospholipids and soya phospholipids

Thompson

Couchoud

Singh

2009

Dairy Sci. Technol.

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“…Clinical studies have indicated improved cognitive function in relation to patients under placebo [21,22], Nootropic substances and enhancers of brain activity such as pyritinol [23,24] are often used for symptomatic treatment of AD, and they may be effective by their acti vation of brain metabolism. In analogy to the positive influence of memory training on forgetfulness in higher age [25], cognitive training programs may also be utilized in AD, and their efficacy might be enhanced by drugs sta bilizing neuronal metabolism [26].…”

mentioning

confidence: 99%

Long-Term Effects of Phosphatidylserine, Pyritinol, and Cognitive Training in Alzheimer's Disease

Heiss¹,

Kessler²,

Mielke³

et al. 1994

Dement Geriatr Cogn Disord

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70 patients with probable Alzheimer''s disease were randomly allocated to four groups: 17 patients received only social support, 18 cognitive training twice a week, in 17 cognitive training was combined with pyritinol 2 x 600 mg/day and in 18 cognitive training was combined with phosphatidylserine 2 x 200 mg/day. Treatment duration was 6 months. Before and after treatment, the patients underwent neuropsychological testing as well as measurement of the regional cerebral metabolic rate for glucose using positron emission tomography and ¹⁸F-2-fluoro-2-deoxy-D-glucose. Before treatment the groups were comparable in respect to resting and activated glucose pattern achieved by a visual recognition task. Electrophysiological changes were assessed as EEG power, globally and in 4 frequency bands. This 6-month study in four groups of patients with Alzheimer''s disease indicated that phosphatidylserine treatment has an effect on different measures of brain function. Since neuropsychological improvements were best documented after 8 and 16 weeks and faded towards the end of the treatment period, it must be concluded that this symptomatic therapy is mainly of short-term benefit and was overcome by the progressive pathological changes at the end of the treatment period.

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“…Oral administration of phosphatidylserine has been shown to affect neuronal membranes, cell metabolism, and specific neurotransmitter systems [1][2][3][4][5] . There are few studies that have examined the efficacy of phosphatidylserine on the improvement of cognition in the elderly population and more information is needed 6 .…”

Section: Introductionmentioning

confidence: 99%

“…Está demonstrado que a administração oral de fosfatidilserina pode afectar as membranas neuronais, o metabolismo celular e sistemas específicos de neurotransmissores [1][2][3][4][5] . Existem poucos estudos que avaliaram a eficácia da fosfatidilserina na melhoria da capacidade cognitiva em idosos sendo necessárias mais informações 6 .…”

Section: Introductionunclassified

Revisiting: “A food supplement is associated with changes in Subjective Memory Complaints and Geriatric Depression Scale in adults and older persons in Portugal”

Tavares

Gomes

Tenreiro³

2013

BBR

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Biomedical and Biopharmaceutical Research J o r n a l d e I n v e s t i g a ç ã o B i o m é d i c a e B i o f a r m a c ê u t i c a AbstractThis study aims to evaluate the effect of phosphatidylserine supplementation on Scale Memory Complaints (SMC) and Geriatric Depression Scale (GDS). A group of healthy adults and elderly people (n= 915) aged 65,65 ± 11,10 years with an education level of 7,56 ± 4,56 years participated in the study. Participants were submitted to the Mini-Mental State Examination (MMSE), SMC and GDS. Four individuals presented cognitive impairment, 874 presented memory complaints and 436 were above cut-off point for GDS. Subsequently, one group of women (n=48) used phosphatidylserine supplementation for 4 weeks. The consumption of phosphatidylserine over the course of 4 weeks significantly decreased SMC (p=0,000) and GDS (p=0.009) values in this group.

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Effects of Phosphatidylserine in Age-Associated Memory Impairment and Alzheimer’s Disease

Cited by 37 publications

References 21 publications

Comparison of hydrophobic and hydrophilic encapsulation using liposomes prepared from milk fat globule-derived phospholipids and soya phospholipids

Comparison of hydrophobic and hydrophilic encapsulation using liposomes prepared from milk fat globule-derived phospholipids and soya phospholipids

Long-Term Effects of Phosphatidylserine, Pyritinol, and Cognitive Training in Alzheimer's Disease

Revisiting: “A food supplement is associated with changes in Subjective Memory Complaints and Geriatric Depression Scale in adults and older persons in Portugal”

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